Influence of temperature on obtaining apatites by sol- gel method
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2023
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BRAZIL MRS MEETING, 21st
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Calcium phosphate-based ceramics (apatites) are synthetic materials that have a chemical
composition similar to bone tissue, which makes them interesting to use as biomaterials [1].
In this work, the apatite precursor sols at concentrations of 0.7 mol/L and 1.4 mol/L are
prepared by dissolving calcium nitrate and phosphorus pentoxide in ethanol. The sols are
kept at rest for 24 hours for hydrolysis (gelatinization) under room temperature and
humidity. After hydrolysis, the resulting gels are dried at 80°C to remove the organic
solvent and then calcined under different temperatures (from 500°C to 1200°C, with
increments of 100°C) for 8h [2]. The X-ray diffraction analysis of the samples by the Rietveld
method indicates that the samples are composed of monoclinic and hexagonal
hydroxyapatite (HAp), the former being predominant, and calcium β-triphosphate (TCP)[3] . For
the material started from the sol with a concentration of 0.7 mol/L, the hydroxyapatite
fraction increases from 28.8% to 66.5% when the calcination temperature increases from
500°C to 800°C. Above this temperature, the fraction of this phase decreases. With a
concentration of 1.4 mol/L, the hydroxyapatite fraction decreases from 88.2% to 19.5%
progressively with increasing temperature from 500°C to 1200°C. The micrographs revealed
the formation of particulate but porous materials that agglomerate without sintering
up to a temperature of 900°C, from where the formation of sintered and dense agglomerates
is observed. The results of the EDX analysis showed a Ca/P molar ratio of around 1.5 for
all materials. The cytotoxicity assay, using pre-osteoblast cells (MC3T3-E1, Subclone 4) by
non-direct contact of 24h, showed that cell viability and adhesion did not differ from those
of the control. A decrease in viability and adhesion was observed for samples prepared at
a concentration of 0.7 mol/L and calcined at temperatures above 900°C.
Como referenciar
GARCIA, JOAO I.M.M.; GOMES, ANDERSON M.; ZAMBUZZI, WILLIAN F.; ICHIKAWA, RODRIGO U.; SAEKI, MARGARIDA J. Influence of temperature on obtaining apatites by sol- gel method. In: BRAZIL MRS MEETING, 21st, October 1-5, 2023, Maceió, AL. Abstract... São Carlos, SP: Aptor Software, 2023. p. 434-434. Disponível em: http://repositorio.ipen.br/handle/123456789/34556. Acesso em: 13 May 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.