Systemic effects

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dc.contributor.authorHAMBLIN, MICHAEL R.
dc.contributor.authorSABINO, CAETANO P.
dc.contributor.editorSELLERA, FABIO P.
dc.contributor.editorNASCIMENTO, CRISTIANE L.
dc.contributor.editorRIBEIRO, MARTHA S.
dc.coverageInternacionalpt_BR
dc.date.accessioned2018-03-06T17:28:21Z
dc.date.available2018-03-06T17:28:21Z
dc.date.issued2016pt_BR
dc.description.abstractPhotodynamic therapy (PDT) is a clinically approved practice for treatment of cancer and infectious diseases. PDT involves systemic or topical administration of a photosensitizer (PS), followed by irradiation of the target area with light of a wavelength matching the absorption band of the PS. In the presence of oxygen, photochemical reactions trigger the production of reactive oxygen species and, consequently, cell death by oxidative stress. Besides causing direct cytotoxicity to tumor cells, PDT induces destruction of the tumor vasculature releasing pro-inflammatory cytokines. Current literature supports that PDT is able to affect both the innate and adaptive responses of the immune system. In addition, PDT-induced adaptive immunity may attack distant untreated tumor cells and lead to development of antitumor memory immunity, which can potentially avoid the cancer relapse. Conversely, pro-inflammatory activity of PDT can also collaborate to resolve local infections since more neutrophils are recruited to the infected region.pt_BR
dc.format.extent73-91pt_BR
dc.identifier.citationHAMBLIN, MICHAEL R.; SABINO, CAETANO P. Systemic effects. In: SELLERA, FABIO P. (ed.); NASCIMENTO, CRISTIANE L. (ed.); RIBEIRO, MARTHA S. (ed.). <b>Photodynamic therapy in veterinary medicine: from basics to clinical practice</b>. Gewerbestrasse, Switzerland: Springer, 2016. p. 73-91. DOI: <a href="https://dx.doi.org/10.1007/978-3-319-45007-0_6">10.1007/978-3-319-45007-0_6</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/28661.
dc.identifier.doi10.1007/978-3-319-45007-0_6pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/28661
dc.localGewerbestrasse, Switzerlandpt_BR
dc.publisherSpringerpt_BR
dc.rightsopenAccesspt_BR
dc.subjectveterinary medicine
dc.subjectanimals
dc.subjectphotodynamic therapy
dc.subjecttumor cells
dc.subjectneoplasms
dc.subjectimmunity
dc.titleSystemic effectspt_BR
dc.title.livroPhotodynamic therapy in veterinary medicine: from basics to clinical practicept_BR
dc.typeCapítulo de livropt_BR
dspace.entity.typePublication
ipen.autorCAETANO PADIAL SABINO
ipen.codigoautor9334
ipen.contributor.ipenauthorCAETANO PADIAL SABINO
ipen.date.recebimento18-03pt_BR
ipen.identifier.ipendoc24645pt_BR
ipen.identifier.ods3
ipen.observacoesLivro na íntegra disponível. Consulte a biblioteca do IPEN.pt_BR
ipen.type.genreCapítulo
relation.isAuthorOfPublicationc113172e-d40f-4643-bfa9-4aa1f607f380
relation.isAuthorOfPublication.latestForDiscoveryc113172e-d40f-4643-bfa9-4aa1f607f380
sigepi.autor.atividadeSABINO, CAETANO P.:9334:-1:Npt_BR
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