Molecular damage

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dc.contributor.authorSABINO, CAETANO P.
dc.contributor.authorHAMBLIN, MICHAEL R.
dc.contributor.editorSELLERA, FABIO P.
dc.contributor.editorNASCIMENTO, CRISTIANE L.
dc.contributor.editorRIBEIRO, MARTHA S.
dc.coverageInternacionalpt_BR
dc.date.accessioned2018-03-06T17:19:59Z
dc.date.available2018-03-06T17:19:59Z
dc.date.issued2016pt_BR
dc.description.abstractPhotodynamic therapy (PDT) rapidly produces large amounts of reactive oxygen species (ROS) to induce death of photosensitized cells. As previously described in Chap. 2, excited photosensitizer (PS) molecules can either donate electrons (type 1) or energy (type 2) to ground-state oxygen to produce superoxide radicals (O2•−) or singlet oxygen (1O2). Each type of ROS has characteristic chemical reactivity and reacts with different types of chemical bonds present in biomolecules and, consequently, will lead to different types of cell damage. Once again, what determines the mechanism of cell death directly depends on both: the PS localization site within the cell and total extent of oxidative stress produced during therapy (i.e., light dosimetry and efficiency of ROS generation). To elucidate the mechanisms of photooxidative damage and the consequent biological effects, this chapter will cover the most relevant chemical reactions related to oxidative damage caused by 1O2 and free radicals.pt_BR
dc.format.extent45-56pt_BR
dc.identifier.citationSABINO, CAETANO P.; HAMBLIN, MICHAEL R. Molecular damage. In: SELLERA, FABIO P. (ed.); NASCIMENTO, CRISTIANE L. (ed.); RIBEIRO, MARTHA S. (ed.). <b>Photodynamic therapy in veterinary medicine: from basics to clinical practice</b>. Gewerbestrasse, Switzerland: Springer, 2016. p. 45-56. DOI: <a href="https://dx.doi.org/10.1007/978-3-319-45007-0_4">10.1007/978-3-319-45007-0_4</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/28659.
dc.identifier.doi10.1007/978-3-319-45007-0_4pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/28659
dc.localGewerbestrasse, Switzerlandpt_BR
dc.publisherSpringerpt_BR
dc.rightsopenAccesspt_BR
dc.subjectveterinary medicine
dc.subjectphotodynamic therapy
dc.subjectoxygen
dc.subjectmolecular structure
dc.subjectphotosensitivity
dc.titleMolecular damagept_BR
dc.title.livroPhotodynamic therapy in veterinary medicine: from basics to clinical practicept_BR
dc.typeCapítulo de livropt_BR
dspace.entity.typePublication
ipen.autorCAETANO PADIAL SABINO
ipen.codigoautor9334
ipen.contributor.ipenauthorCAETANO PADIAL SABINO
ipen.date.recebimento18-03pt_BR
ipen.identifier.ipendoc24457pt_BR
ipen.observacoesLivro na íntegra disponível. Consulte a biblioteca do IPEN.pt_BR
ipen.type.genreCapítulo
relation.isAuthorOfPublicationc113172e-d40f-4643-bfa9-4aa1f607f380
relation.isAuthorOfPublication.latestForDiscoveryc113172e-d40f-4643-bfa9-4aa1f607f380
sigepi.autor.atividadeSABINO, CAETANO P.:9334:-1:Npt_BR
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