Brain STAT5 signaling modulates learning and memory formation

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dc.contributor.authorFURIGO, ISADORA C.
dc.contributor.authorMELO, HELEN M.
dc.contributor.authorSILVA, NATALIA M.L. e
dc.contributor.authorRAMOS-LOBO, ANGELA M.
dc.contributor.authorTEIXEIRA, PRYSCILA D.S.
dc.contributor.authorBUONFIGLIO, DANIELLA C.
dc.contributor.authorWASINSKI, FREDERICK
dc.contributor.authorLIMA, ELIANA R.
dc.contributor.authorHIGUTI, ELIZA
dc.contributor.authorPERONI, CIBELE N.
dc.contributor.authorBARTOLINI, PAOLO
dc.contributor.authorSOARES, CARLOS R.J.
dc.contributor.authorMETZGER, MARTIN
dc.contributor.authorFELICE, FERNANDA G. de
dc.contributor.authorDONATO JUNIOR, JOSE
dc.coverageInternacionalpt_BR
dc.date.accessioned2018-07-16T17:17:59Z
dc.date.available2018-07-16T17:17:59Z
dc.date.issued2018pt_BR
dc.description.abstractThe signal transducer and activator of transcription 5 (STAT5) is a transcription factor recruited by numerous cytokines. STAT5 is important for several physiological functions, including body and tissue growth, mammary gland development, immune system and lipid metabolism. However, the role of STAT5 signaling for brain functions is still poorly investigated, especially regarding cognitive aspects. Therefore, the objective of the present study was to investigate whether brain STAT5 signaling modulates learning and memory formation. For this purpose, brain-specific STAT5 knockout (STAT5 KO) mice were studied in well-established memory tests. Initially, we confirmed a robust reduction in STAT5a and STAT5b mRNA levels in different brain structures of STAT5 KO mice. STAT5 KO mice showed no significant alterations in metabolism, growth, somatotropic axis and spontaneous locomotor activity. In contrast, brain-specific STAT5 ablation impaired learning and memory formation in the novel object recognition, Barnes maze and contextual fear conditioning tests. To unravel possible mechanisms that might underlie the memory deficits of STAT5 KO mice, we assessed neurogenesis in the hippocampus, but no significant differences were observed between groups. On the other hand, reduced insulin-like growth factor-1 (IGF-1) mRNA expression was found in the hippocampus and hypothalamus of STAT5 KO mice. These findings collectively indicate that brain STAT5 signaling is required to attain normal learning and memory. Therefore, STAT5 is an important downstream cellular mechanism shared by several cytokines to regulate cognitive functions.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 12/24345-4; 12/02388-3; 14/11752-6; 15/10992-6; 16/09679-4; 16/20897-3; 17/02983-2pt_BR
dc.format.extent2229-2241pt_BR
dc.identifier.citationFURIGO, ISADORA C.; MELO, HELEN M.; SILVA, NATALIA M.L. e; RAMOS-LOBO, ANGELA M.; TEIXEIRA, PRYSCILA D.S.; BUONFIGLIO, DANIELLA C.; WASINSKI, FREDERICK; LIMA, ELIANA R.; HIGUTI, ELIZA; PERONI, CIBELE N.; BARTOLINI, PAOLO; SOARES, CARLOS R.J.; METZGER, MARTIN; FELICE, FERNANDA G. de; DONATO JUNIOR, JOSE. Brain STAT5 signaling modulates learning and memory formation. <b>Brain Structure and Function</b>, v. 223, n. 5, p. 2229-2241, 2018. DOI: <a href="https://dx.doi.org/10.1007/s00429-018-1627-z">10.1007/s00429-018-1627-z</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/28950.
dc.identifier.doi10.1007/s00429-018-1627-zpt_BR
dc.identifier.fasciculo5pt_BR
dc.identifier.issn1863-2653pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7982-1789
dc.identifier.orcidhttps://orcid.org/0000-0001-8194-5230
dc.identifier.percentilfi81.30en
dc.identifier.percentilfiCiteScore88.00
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/28950
dc.identifier.vol223pt_BR
dc.relation.ispartofBrain Structure and Functionpt_BR
dc.rightsopenAccesspt_BR
dc.subjectlymphokines
dc.subjecttranscription
dc.subjecttransducers
dc.subjecthypothalamus
dc.subjecthippocampus
dc.subjectreceptors
dc.subjectbrain
dc.subjectcerebral cortex
dc.titleBrain STAT5 signaling modulates learning and memory formationpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorELIZA HIGUTI
ipen.autorCARLOS ROBERTO JORGE SOARES
ipen.autorPAOLO BARTOLINI
ipen.autorCIBELE NUNES PERONI
ipen.autorELIANA ROSA LIMA FILHA
ipen.codigoautor6667
ipen.codigoautor509
ipen.codigoautor1503
ipen.codigoautor947
ipen.codigoautor10276
ipen.contributor.ipenauthorELIZA HIGUTI
ipen.contributor.ipenauthorCARLOS ROBERTO JORGE SOARES
ipen.contributor.ipenauthorPAOLO BARTOLINI
ipen.contributor.ipenauthorCIBELE NUNES PERONI
ipen.contributor.ipenauthorELIANA ROSA LIMA FILHA
ipen.date.recebimento18-07pt_BR
ipen.identifier.fi2.622pt_BR
ipen.identifier.fiCiteScore7.3
ipen.identifier.ipendoc24735pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi75.00 - 100.00
ipen.type.genreArtigo
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relation.isAuthorOfPublication29795401-0903-48c6-9fd6-da40a6d603dd
relation.isAuthorOfPublication.latestForDiscovery29795401-0903-48c6-9fd6-da40a6d603dd
sigepi.autor.atividadeLIMA, ELIANA R.:10276:-1:Spt_BR
sigepi.autor.atividadeHIGUTI, ELIZA:6667:-1:Npt_BR
sigepi.autor.atividadePERONI, CIBELE N.:947:810:Npt_BR
sigepi.autor.atividadeBARTOLINI, PAOLO:1503:810:Npt_BR
sigepi.autor.atividadeSOARES, CARLOS R.J.:509:810:Npt_BR
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