Hypanus americanus mucus

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dc.contributor.authorCOELHO, GUILHERME R.pt_BR
dc.contributor.authorPREZOTTO NETO, JOSE P.pt_BR
dc.contributor.authorBARBOSA, FERNANDA C.pt_BR
dc.contributor.authorSANTOS, RAFAEL S.pt_BR
dc.contributor.authorBRIGATTE, PATRICIApt_BR
dc.contributor.authorSPENCER, PATRICK J.pt_BR
dc.contributor.authorSAMPAIO, SANDRA C.pt_BR
dc.contributor.authorD'AMELIO, FERNANDApt_BR
dc.contributor.authorPIMENTA, DANIEL C.pt_BR
dc.contributor.authorSCIANI, JULIANA M.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2020-12-17T19:46:17Z
dc.date.available2020-12-17T19:46:17Z
dc.date.issued2020pt_BR
dc.description.abstractFish skin plays important biological roles, such as the control of the osmotic pressure gradient, protection against mechanical forces and microorganism infections. The mucus, on the other hand, is a rich and complex fluid, important for the fish acting as innate immunity system, swimming and nutrition. The elasmobranch epidermis is characterized mainly by mucus secretory cells, and marine stingrays have already been described to present secretory glands spread throughout the body. Little is known about the biochemical composition of the stingray mucus, but recent studies denoted the importance of mucus in the envenomation process. Stingrays venom are largely studied due the human medical importance of envenoming caused by sting puncture, that evolve with local inflammation and necrosis, and these toxic events can be correlated to the chemical composition of the sting skin, according to the literature. Aiming to analyse the mucus composition, a new non-invasive mucus collection method was developed that focused on peptides and proteins, and biological assays were performed to analyze preliminary toxic and immune activities of the Hypanus americanus mucus. Pathophysiological characterization showed the presence of peptidases on mucus, as well that the induction of edema and leukocyte recruitment in mice. The fractionated mucus improved phagocytosis on macrophages and showed antimicrobial activity against T. rubrum, C. neoformans and C. albicans in vitro. The proteomic analyses showed the presence of immune-related proteins like actin, histones, hemoglobin, and ribosomal proteins. This protein pattern is similar to those reported for other fish mucus and stingray venom. This is the first report depicting the Hypanus stingray mucus composition, highlighting its biochemical composition and importance for the stingray immune system and the possible role on the envenomation process.pt_BR
dc.format.extentS34-S34pt_BR
dc.identifier.citationCOELHO, GUILHERME R.; PREZOTTO NETO, JOSE P.; BARBOSA, FERNANDA C.; SANTOS, RAFAEL S.; BRIGATTE, PATRICIA; SPENCER, PATRICK J.; SAMPAIO, SANDRA C.; D'AMELIO, FERNANDA; PIMENTA, DANIEL C.; SCIANI, JULIANA M. Hypanus americanus mucus: a new point of view about stingray immunity and toxins. <b>Toxicon</b>, v. 177, p. S34-S34, 2020. Supplement 1. DOI: <a href="https://dx.doi.org/10.1016/j.toxicon.2019.12.047">10.1016/j.toxicon.2019.12.047</a>. Disponível em: http://200.136.52.105/handle/123456789/31673.
dc.identifier.doi10.1016/j.toxicon.2019.12.047pt_BR
dc.identifier.issn0041-0101pt_BR
dc.identifier.orcid0000-0001-8949-7735pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8949-7735
dc.identifier.percentilfi30.372pt_BR
dc.identifier.suplementoSupplement 1pt_BR
dc.identifier.urihttp://200.136.52.105/handle/123456789/31673
dc.identifier.vol177pt_BR
dc.relation.ispartofToxiconpt_BR
dc.rightsopenAccesspt_BR
dc.sourceWorld Congress of the International Society on Toxinology, 20th, September 8-13, 2019, Buenos Aires, Argentinapt_BR
dc.subjectfishes
dc.subjectskin
dc.subjectvenoms
dc.subjecttherapeutic uses
dc.titleHypanus americanus mucuspt_BR
dc.typeResumos em periódicospt_BR
dspace.entity.typePublication
ipen.autorPATRICK JACK SPENCER
ipen.autorJOSE PEDRO PREZOTTO NETO
ipen.codigoautor910
ipen.codigoautor12680
ipen.contributor.ipenauthorPATRICK JACK SPENCER
ipen.contributor.ipenauthorJOSE PEDRO PREZOTTO NETO
ipen.date.recebimento20-12
ipen.identifier.fi2.201pt_BR
ipen.identifier.ipendoc27445pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi25.00 - 49.99
ipen.subtituloa new point of view about stingray immunity and toxinspt_BR
ipen.type.genreResumo
relation.isAuthorOfPublication4eb7939e-aeea-4991-8525-b3d05ac27364
relation.isAuthorOfPublicationd12e99d3-6200-48af-8a52-be6512009419
relation.isAuthorOfPublication.latestForDiscoveryd12e99d3-6200-48af-8a52-be6512009419
sigepi.autor.atividadeSPENCER, PATRICK J.:910:810:Npt_BR
sigepi.autor.atividadePREZOTTO NETO, JOSE P.:12680:810:Npt_BR
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