Evaluation of the influence of the conjugation site of the chelator agent HYNIC to GLP1 antagonist radiotracer for insulinoma diagnosis

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dc.contributor.authorFAINTUCH, BLUMA L.
dc.contributor.authorSEO, DANIELE
dc.contributor.authorOLIVEIRA, ERICA A. de
dc.contributor.authorTARGINO, ROSELAINE C.
dc.contributor.authorMORO, ANA M.
dc.coverageInternacionalpt_BR
dc.date.accessioned2017-08-14T17:09:36Z
dc.date.available2017-08-14T17:09:36Z
dc.date.issued2017pt_BR
dc.description.abstractBackground and Objective: Radiotracer diagnosis of insulinoma, can be done using somatostatin or glucagon-like peptide 1 (GLP-1). Performance of GLP-1 antagonists tends to be better than of agonists. Methods: We investigated the uptake of the antagonist exendin (9-39), radiolabeled with technetium-99m. Two different sites of the biomolecule were selected for chelator attachment. Results: HYNIC-beta Ala chelator attached to serine (C-terminus) of exendin, was associated with higher tumor uptake than to aspartate (N-terminus). Conclusion: The chelator position in the biomolecule influenced receptor uptake.pt_BR
dc.format.extent65-72pt_BR
dc.identifier.citationFAINTUCH, BLUMA L.; SEO, DANIELE; OLIVEIRA, ERICA A. de; TARGINO, ROSELAINE C.; MORO, ANA M. Evaluation of the influence of the conjugation site of the chelator agent HYNIC to GLP1 antagonist radiotracer for insulinoma diagnosis. <b>Current Radiopharmaceuticals</b>, v. 10, n. 1, p. 65-72, 2017. DOI: <a href="https://dx.doi.org/10.2174/1874471010666170126143636">10.2174/1874471010666170126143636</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/27705.
dc.identifier.doi10.2174/1874471010666170126143636pt_BR
dc.identifier.fasciculo1pt_BR
dc.identifier.issn1874-4729pt_BR
dc.identifier.percentilfiSem Percentilen
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/27705
dc.identifier.vol10pt_BR
dc.relation.ispartofCurrent Radiopharmaceuticalspt_BR
dc.rightsclosedAccesspt_BR
dc.subjecttracer techniques
dc.subjectinsulin
dc.subjectglucagon
dc.subjectpeptide hormones
dc.subjecttechnetium 99
dc.titleEvaluation of the influence of the conjugation site of the chelator agent HYNIC to GLP1 antagonist radiotracer for insulinoma diagnosispt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorDANIELE SEO
ipen.autorERICA APARECIDA DE OLIVEIRA
ipen.autorBLUMA LINKOWSKI FAINTUCH
ipen.codigoautor6400
ipen.codigoautor9158
ipen.codigoautor51
ipen.contributor.ipenauthorDANIELE SEO
ipen.contributor.ipenauthorERICA APARECIDA DE OLIVEIRA
ipen.contributor.ipenauthorBLUMA LINKOWSKI FAINTUCH
ipen.date.recebimento17-08pt_BR
ipen.identifier.fiSem F.I.pt_BR
ipen.identifier.ipendoc23933pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods3
ipen.type.genreArtigo
relation.isAuthorOfPublicationc96def2e-d2f1-4481-8209-ed17f2ffc2e6
relation.isAuthorOfPublication5389c24b-46b6-429c-9901-ced453124943
relation.isAuthorOfPublicatione86aa86f-0601-4b44-aa7a-3ad168745a77
relation.isAuthorOfPublication.latestForDiscoverye86aa86f-0601-4b44-aa7a-3ad168745a77
sigepi.autor.atividadeFAINTUCH, BLUMA L.:51:110:Spt_BR
sigepi.autor.atividadeSEO, DANIELE:6400:110:Npt_BR
sigepi.autor.atividadeOLIVEIRA, ERICA A. DE:9158:-1:Npt_BR
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