Effects of doxorubicin on the structural and morphological characterization of solid lipid nanoparticles (SLN) using small angle neutron scattering (SANS) and small angle X-ray scattering (SAXS)

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dc.contributor.authorYOKAICHIYA, FABIANO
dc.contributor.authorSCHMIDT, CHRISTIAN
dc.contributor.authorSTORSBERG, JOACHIM
dc.contributor.authorVOLLRATH, MONT K.
dc.contributor.authorARAUJO, DANIELE R. de
dc.contributor.authorKENT, BEN
dc.contributor.authorCLEMENS, DANIEL
dc.contributor.authorWINGERT, FRIEDRICH
dc.contributor.authorFRANCO, MARGARETH K.K.D.
dc.coverageInternacionalpt_BR
dc.date.accessioned2018-02-20T12:06:38Z
dc.date.available2018-02-20T12:06:38Z
dc.date.issued2018pt_BR
dc.description.abstractCancer is still a major public health problem. Leaving detection of early stages of tumors and other issues aside, minimizing unwarranted side effects, for example after clinical usage of a liposomal anticancer drug doxorubicin (Dox) formulation, is an unmet clinical problem and the focus of many studies. Using compounds typically used in the preparation of food and/or cosmetics to prepare drug carrier systems, we observed that sodium tetradecyl sulfate (STS) containing and soybean-oil based carriers are more efficient in reducing the viability of HeLa cells tumor cells in comparison to their respective counterparts. Here, we probe the doxorubicin (Dox) loading on structural properties of either soybean oil or coconut oil (Mygliol 812) formulations. Small angle neutron scattering (SANS) assays were performed using V16 instrument at Helmholtz-Zentrum Berlin (HZB) at 25, 37 and 40 C with two or 11m distance between detector and sample to assess a wide range in scattering vector Q. Combined with previous measurement using small angle X-ray scattering (SAXS), our results show that the Dox has different influence in the surface structure of the solid lipid nanoparticles (SLN) and also affects the fractality in the vesicle aggregates when the concentration of the drug is altered, for Mygliol and soybean oil SLN drug delivery carrier systems.pt_BR
dc.format.extent191-196pt_BR
dc.identifier.citationYOKAICHIYA, FABIANO; SCHMIDT, CHRISTIAN; STORSBERG, JOACHIM; VOLLRATH, MONT K.; ARAUJO, DANIELE R. de; KENT, BEN; CLEMENS, DANIEL; WINGERT, FRIEDRICH; FRANCO, MARGARETH K.K.D. Effects of doxorubicin on the structural and morphological characterization of solid lipid nanoparticles (SLN) using small angle neutron scattering (SANS) and small angle X-ray scattering (SAXS). <b>Physica B: Condensed Matter</b>, v. 551, p. 191-196, 2018. DOI: <a href="https://dx.doi.org/10.1016/j.physb.2017.12.036">10.1016/j.physb.2017.12.036</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/28506.
dc.identifier.doi10.1016/j.physb.2017.12.036pt_BR
dc.identifier.issn0921-4526pt_BR
dc.identifier.percentilfi43.38en
dc.identifier.percentilfiCiteScore54.67
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/28506
dc.identifier.vol551pt_BR
dc.relation.ispartofPhysica B: Condensed Matterpt_BR
dc.rightsopenAccesspt_BR
dc.subjectdoxorubicin
dc.subjectdrug delivery
dc.subjecthela cells
dc.subjectnanoparticles
dc.subjectneoplasms
dc.subjectneutron diffraction
dc.subjectsmall angle scattering
dc.subjectsodium sulfates
dc.subjectsolids
dc.subjectsoybean oil
dc.subjectsoybean oil
dc.subjectx-ray diffraction
dc.titleEffects of doxorubicin on the structural and morphological characterization of solid lipid nanoparticles (SLN) using small angle neutron scattering (SANS) and small angle X-ray scattering (SAXS)pt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorMARGARETH KAZUYO KOBAYASHI DIAS FRANCO
ipen.codigoautor9803
ipen.contributor.ipenauthorMARGARETH KAZUYO KOBAYASHI DIAS FRANCO
ipen.date.recebimento18-02pt_BR
ipen.identifier.fi1.874pt_BR
ipen.identifier.fiCiteScore2.6
ipen.identifier.ipendoc24321pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods3
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi25.00 - 49.99
ipen.type.genreArtigo
relation.isAuthorOfPublicationea01b86e-8435-405e-874c-d0b68fb2b549
relation.isAuthorOfPublication.latestForDiscoveryea01b86e-8435-405e-874c-d0b68fb2b549
sigepi.autor.atividadeFRANCO, MARGARETH K.K.D.:9803:310:Npt_BR
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