Brazil radioactive sources production for cancer treatment

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dc.contributor.authorROSTELATO, MARIA E.
dc.contributor.authorSOUZA, CARLA D.
dc.contributor.authorZEITUNI, CARLOS A.
dc.contributor.authorMOURA, JOAO A.
dc.contributor.authorMARQUES, JOSE R.O.
dc.contributor.authorCOSTA, OSVALDO L.
dc.contributor.authorFEHER, ANSELMO
dc.contributor.authorRODRIGUES, BRUNA T.
dc.contributor.authorSOUZA, DAIANE C.B. de
dc.contributor.authorPELEIAS JUNIOR, FERNANDO S.
dc.contributor.authorSORGATTI, ANDERSON
dc.contributor.authorMOSCA, RODRIGO
dc.contributor.authorMOURA, EDUARDO S. de
dc.contributor.authorABREU, RODRIGO T.
dc.contributor.authorSOUZA, RAQUEL V. DE
dc.contributor.authorNOGUEIRA, BEATRIZ R.
dc.coverageInternacionalpt_BR
dc.date.accessioned2017-12-18T12:51:19Z
dc.date.available2017-12-18T12:51:19Z
dc.date.issued2016pt_BR
dc.description.abstractThe modality, known as brachytherapy, was performed in Brazil by only a hand full of hospitals at an extremely high cost. For producing new sources, five major areas must be considered: 1) source production: nuclear activation and/or radiochemical reaction; 2) welding; 3) Quality control: leakage tests; 4) Dosimetry and metrology; 5) Operational procedures; 6) validation studies. To perform all steps, a multidisciplinary team works together to overcome difficulties. - Iridium-192 pellets: In Brazil there are 140 machines with pellets that replacement every 5 years. Our new production line has assembly, welding and quality control hot cells. - Iridium-192 wires: Produced since 1999. The wire is activated at IPENs IEA-R1 reactor for 30 hours with 5x1013 n/cm-2.s-1 neutron flux resulting in 192 mCi maximum activity. - Iridium-192 seed: New seed for ophthalmic cancer treatment. The irradiation device presented 90% activity homogeneity. We are still testing in-vivo. - Iodine-125 seeds: Largely used in low dose brachytherapy. I-125 binding yield achieved with our new reaction was 80%; Laser welding presented 70% efficiency. Approved in all leakage tests. - Other ongoing projects: Veterinary brachytherapy, Waste management, Radionecrosis healing with laser, calibrations sources production, linear accelerator calculations for hospitals, sources with polymeric matrix Our Iodine-125 seeds will be available in 2018. All other projects are advancing. We will continue to develop new products hoping to help the Brazilian population fight against cancer. For producing new sources, five major areas must be considered: 1) source production: nuclear activation and/or radiochemical reaction; 2) welding; 3) Quality control:eakage tests; 4) Dosimetry and metrology; 5) Operational procedures; 6) validation studies. To perform all steps, a multidisciplinary team works together to overcome difficultiespt_BR
dc.format.extent237-237pt_BR
dc.identifier.citationROSTELATO, MARIA E.; SOUZA, CARLA D.; ZEITUNI, CARLOS A.; MOURA, JOAO A.; MARQUES, JOSE R.O.; COSTA, OSVALDO L.; FEHER, ANSELMO; RODRIGUES, BRUNA T.; SOUZA, DAIANE C.B. de; PELEIAS JUNIOR, FERNANDO S.; SORGATTI, ANDERSON; MOSCA, RODRIGO; MOURA, EDUARDO S. de; ABREU, RODRIGO T.; SOUZA, RAQUEL V. DE; NOGUEIRA, BEATRIZ R. Brazil radioactive sources production for cancer treatment. <b>Medical Physics International</b>, v. 4, n. 2, p. 237-237, 2016. Disponível em: http://repositorio.ipen.br/handle/123456789/28170.
dc.identifier.fasciculo2pt_BR
dc.identifier.issn2306-4609pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5054-0799
dc.identifier.orcidhttps://orcid.org/0000-0002-7303-6720
dc.identifier.orcidhttp://orcid.org/0000-0003-1335-8864
dc.identifier.orcidhttps://orcid.org/0000-0003-2943-6097
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/28170
dc.identifier.vol4pt_BR
dc.relation.ispartofMedical Physics Internationalpt_BR
dc.rightsopenAccesspt_BR
dc.sourceINTERNATIONAL ORGANIZATION FOR MEDICAL PHYSICS; INTERNATIONAL CONFERENCE ON MEDICAL PHYSICS, December, 09-12, 2016, Bangkok, Thailandpt_BR
dc.subjectirradiation devices
dc.subjectionizing radiations
dc.subjectbrachytherapy
dc.subjectneoplasms
dc.subjectiodine 125
dc.subjectiridium 192
dc.subjectradiation sources
dc.subjectbrazil
dc.titleBrazil radioactive sources production for cancer treatmentpt_BR
dc.typeResumos em periódicospt_BR
dspace.entity.typePublication
ipen.autorJOÃO AUGUSTO MOURA
ipen.autorANSELMO FEHER
ipen.autorFERNANDO DOS SANTOS PELEIAS JUNIOR
ipen.autorRODRIGO TEIXEIRA DE ABREU
ipen.autorRAQUEL VALERIO DE SOUZA
ipen.autorBEATRIZ RIBEIRO NOGUEIRA
ipen.autorEDUARDO SANTANA DE MOURA
ipen.autorRODRIGO CRESPO MOSCA
ipen.autorANDERSON SORGATTI DE SOUZA
ipen.autorDAIANE CRISTINI BARBOSA DE SOUZA
ipen.autorBRUNA TEIGA RODRIGUES
ipen.autorOSVALDO LUIZ DA COSTA
ipen.autorJOSE RONALDO DE OLIVEIRA MARQUES
ipen.autorCARLOS ALBERTO ZEITUNI
ipen.autorCARLA DARUICH DE SOUZA
ipen.autorMARIA ELISA CHUERY MARTINS ROSTELATO
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ipen.contributor.ipenauthorJOÃO AUGUSTO MOURA
ipen.contributor.ipenauthorANSELMO FEHER
ipen.contributor.ipenauthorFERNANDO DOS SANTOS PELEIAS JUNIOR
ipen.contributor.ipenauthorRODRIGO TEIXEIRA DE ABREU
ipen.contributor.ipenauthorRAQUEL VALERIO DE SOUZA
ipen.contributor.ipenauthorBEATRIZ RIBEIRO NOGUEIRA
ipen.contributor.ipenauthorEDUARDO SANTANA DE MOURA
ipen.contributor.ipenauthorRODRIGO CRESPO MOSCA
ipen.contributor.ipenauthorANDERSON SORGATTI DE SOUZA
ipen.contributor.ipenauthorDAIANE CRISTINI BARBOSA DE SOUZA
ipen.contributor.ipenauthorBRUNA TEIGA RODRIGUES
ipen.contributor.ipenauthorOSVALDO LUIZ DA COSTA
ipen.contributor.ipenauthorJOSE RONALDO DE OLIVEIRA MARQUES
ipen.contributor.ipenauthorCARLOS ALBERTO ZEITUNI
ipen.contributor.ipenauthorCARLA DARUICH DE SOUZA
ipen.contributor.ipenauthorMARIA ELISA CHUERY MARTINS ROSTELATO
ipen.date.recebimento17-12pt_BR
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