Galectins in host defense against microbial infections

Página do item simplificado
dc.contributor.authorLI, FANG-YENpt_BR
dc.contributor.authorWANG, SHENG-FANpt_BR
dc.contributor.authorBERNARDES, EMERSON S.pt_BR
dc.contributor.authorLIU, FU-TONGpt_BR
dc.contributor.editorHSIEH, SHIE-LIANGpt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2021-03-10T18:24:41Z
dc.date.available2021-03-10T18:24:41Z
dc.date.issued2020pt_BR
dc.description.abstractGalectins are differentially expressed in a variety of cell types, including immune cells, and characterized by the affinity for β-galactoside–containing glycans. There are fifteen galectin members in mammals. Galectins are primarily located intracellularly, but can be secreted outside the cells. They exhibit pivotal roles during microbial infection, such as pathogen recognition and innate and adaptive immunity, and this review aims to discuss the functions of endogenous galectins during infection by four main types of microbes (bacteria, fungi, viruses, and parasites). Extracellular galectins are known to exert a bacteriostatic effect on some bacteria via association with bacterial glycans, whereas cytosolic galectins are recognized to control antibacterial autophagy by binding to luminal host glycans of ruptured endo-lysosomes. With regard to fungal infections, most studies deal with galectin-3. Galectin-3 modulates fungal burdens, the adaptive immune responses, and mortality in fungi-infected mice, which has been shown to be associated with its ability to manipulate fungicidal functions in neutrophils and cytokine expression in dendritic cells. Some viral infections, such as human immunodeficiency virus (HIV) and influenza virus infections, can be regulated by galectin-1 and -3, and they affect various aspects of viral infections, including viral binding, replication, budding, transmission, and infection-associated inflammation. Functions of galectins during a number of different parasitic infections have been identified in studies using galectin-knockout mice. Different parasitic infections have consistently demonstrated a role of galectins in tuning T helper immune responses in infected hosts.pt_BR
dc.format.extent141-167pt_BR
dc.identifier.capitulo6pt_BR
dc.identifier.citationLI, FANG-YEN; WANG, SHENG-FAN; BERNARDES, EMERSON S.; LIU, FU-TONG. Galectins in host defense against microbial infections. In: HSIEH, SHIE-LIANG (ed.). <b>Lectin in Host Defense Against Microbial Infections</b>. Singapore: Springer Nature Singapore, 2020. , cap. 6. p. 141-167. (Advances in Experimental Medicine and Biology, 1204). DOI: <a href="https://dx.doi.org/10.1007/978-981-15-1580-4_6">10.1007/978-981-15-1580-4_6</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31909.
dc.identifier.doi10.1007/978-981-15-1580-4_6pt_BR
dc.identifier.orcid0000-0002-0029-7313pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0029-7313
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31909
dc.localSingaporept_BR
dc.publisherSpringer Nature Singaporept_BR
dc.relation.ispartofseriesAdvances in Experimental Medicine and Biology, 1204pt_BR
dc.rightsclosedAccesspt_BR
dc.subjectparasites
dc.subjectviruses
dc.subjectbacteria
dc.subjectfungi
dc.subjectimmunity
dc.subjectimmune reactions
dc.subjectgalactose
dc.titleGalectins in host defense against microbial infectionspt_BR
dc.title.livroLectin in Host Defense Against Microbial Infectionspt_BR
dc.typeCapítulo de livropt_BR
dspace.entity.typePublication
ipen.autorEMERSON SOARES BERNARDES
ipen.codigoautor12099
ipen.contributor.ipenauthorEMERSON SOARES BERNARDES
ipen.date.recebimento21-03
ipen.identifier.ipendoc27680pt_BR
ipen.identifier.ods3
ipen.identifier.ods5
ipen.type.genreCapítulo
relation.isAuthorOfPublication8115c8bd-822c-4f5a-9f49-3c12570ed40a
relation.isAuthorOfPublication.latestForDiscovery8115c8bd-822c-4f5a-9f49-3c12570ed40a
sigepi.autor.atividadeBERNARDES, EMERSON S.:12099:110:Npt_BR
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
27680.pdf
Tamanho:
225.9 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar
Coleções
Capítulos