Radiolytic synthesis of non-toxic, size-homogeneous gold nanoparticles

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dc.contributor.authorFREITAS, L.F.
dc.contributor.authorKUCHINSKI, A.C.
dc.contributor.authorLUGAO, A.B.
dc.contributor.editorBURITI, JOSUE da S.
dc.contributor.editorCRUZ, RITA de C.A.L.
dc.contributor.editorFOOK, MARCUS V.L.
dc.coverageNacionalpt_BR
dc.creator.eventoCONGRESSO DA SOCIEDADE LATINO AMERICANA DE BIOMATERIAIS, ORGÃOS ARTIFICIAIS E ENGENHARIA DE TECIDOS, 15.; CONGRESSO LATINO AMERICANO DE ÓRGÃOS ARTIFICIAIS E BIOMATERIAIS, 10.pt_BR
dc.date.accessioned2019-02-06T13:26:30Z
dc.date.available2019-02-06T13:26:30Z
dc.date.evento22 a 25 de agosto, 2018pt_BR
dc.description.abstractRadiolytic synthesis of nanoparticles is one of the successful examples of Green Chemistry (the use of non-toxic chemicals, environmentally benign solvents and renewable materials during the chemical processes), in which the reducing agents responsible for the particle nucleation are no other than the reactive species generated by the radiolysis of the solvent itself (i.e. water, acetone or alcohols). This study consists on the radiolytic synthesis and characterization of gold nanoparticles, as well as the assessment of their toxicity levels to Zebrafish embryos (Danio rerio), as an indication of a possible environmental effect. The nanoparticles were synthesized by mixing: NaAuCl4 2 x 10-3 M; polyvinylpyrrolidone 100 kDa 0.5% (as size stabilizer); propan-2-ol 0.2 M and acetone 0.06 M (for the generation of propyl radicals); and AgNO3 6 x 10-5 M (another size stabilizer), followed by 10 kGy of gamma radiation (5 kGy h-1) [1]. The particles were characterized by their absorption spectra in the UV and visible, and the dynamic light scattering (DLS) technique was used to assess their hydrodynamic size. Finally, the impact on the development of Zebrafish embryos was investigated for different dilutions of the nanoparticles suspension, according to the OECD protocol nº 236 (Guideline on Fish Embryo Acute Toxicity Test – FET), as a means of assessing the environmental impact of the nanomaterial. An acute (96 hours of exposition to gold nanoparticles) and a chronic (168 hours of exposition) assay were performed. The particles were successfully synthesized in a nuclear reactor, with an absorption peak at 532 nm and a narrow size distribution (around 25 nm). There was no evident toxicity for the fish in any tested concentration, leading to the conclusion that this green method of nanoparticle synthesis generates a potentially environment-safe material, with good control of size and optical properties.pt_BR
dc.event.siglaSLABO; COLAOBpt_BR
dc.format.extent154-154pt_BR
dc.identifier.citationFREITAS, L.F.; KUCHINSKI, A.C.; LUGAO, A.B. Radiolytic synthesis of non-toxic, size-homogeneous gold nanoparticles. In: BURITI, JOSUE da S. (ed.); CRUZ, RITA de C.A.L. (ed.); FOOK, MARCUS V.L. (ed.). In: CONGRESSO DA SOCIEDADE LATINO AMERICANA DE BIOMATERIAIS, ORGÃOS ARTIFICIAIS E ENGENHARIA DE TECIDOS, 15.; CONGRESSO LATINO AMERICANO DE ÓRGÃOS ARTIFICIAIS E BIOMATERIAIS, 10., 22 a 25 de agosto, 2018, João Pessoa, PB. <b>Resumo...</b> Belo Horizonte, MG: Sociedade Latino Americana de Biomateriais, Engenharia de Tecidos e Órgãos Artificiais, 2018. p. 154-154. Disponível em: http://repositorio.ipen.br/handle/123456789/29487.
dc.identifier.orcidaguardandopt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29487
dc.localBelo Horizonte, MGpt_BR
dc.local.eventoJoão Pessoa, PBpt_BR
dc.publisherSociedade Latino Americana de Biomateriais, Engenharia de Tecidos e Órgãos Artificiaispt_BR
dc.rightsopenAccesspt_BR
dc.subjectradiolysis
dc.subjectsynthesis
dc.subjectchemistry
dc.subjectecology
dc.subjectsustainability
dc.subjectgold
dc.subjectnanoparticles
dc.subjectwater pollution
dc.subjectfishes
dc.titleRadiolytic synthesis of non-toxic, size-homogeneous gold nanoparticlespt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorADRIANA KUCHINSKI CAVALCANTE
ipen.autorLUCAS FREITAS DE FREITAS
ipen.codigoautor339
ipen.codigoautor12073
ipen.codigoautor14818
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorADRIANA KUCHINSKI CAVALCANTE
ipen.contributor.ipenauthorLUCAS FREITAS DE FREITAS
ipen.date.recebimento19-02pt_BR
ipen.event.datapadronizada2018pt_BR
ipen.identifier.ipendoc25275pt_BR
ipen.notas.internasResumopt_BR
ipen.type.genreResumo
relation.isAuthorOfPublication99ac24c5-2ae1-465a-a6f2-40b4d9af6af7
relation.isAuthorOfPublicationb0ca3d5f-34ef-4296-a9ef-afb8e9886957
relation.isAuthorOfPublication05be75ae-89a2-47f4-a13a-7723b50a6bd0
relation.isAuthorOfPublication.latestForDiscovery05be75ae-89a2-47f4-a13a-7723b50a6bd0
sigepi.autor.atividadeFREITAS, L.F.:14818:-1:Spt_BR
sigepi.autor.atividadeKUCHINSKI, A.C.:12073:740:Npt_BR
sigepi.autor.atividadeLUGAO, A.B.:339:740:Npt_BR
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