Amorphous calcium phosphate (ACP) in tissue repair process

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dc.contributor.authorALLEGRINI JUNIOR, SERGIO
dc.contributor.authorSILVA, ANTONIO C. da
dc.contributor.authorTSUJITA, MARISTELA
dc.contributor.authorSALLES, MARCOS B.
dc.contributor.authorGEHRKE, SERGIO A.
dc.contributor.authorBRAGA, FRANCISCO J.C.
dc.coverageInternacionalpt_BR
dc.date.accessioned2018-07-17T10:43:07Z
dc.date.available2018-07-17T10:43:07Z
dc.date.issued2018pt_BR
dc.description.abstractSynthetic biomaterials submitted to new structural technologies have become ideal for the recovery of traumatized bone tissues and some bone substitutes such as bioactive glass, β‐Tricalcium phosphate (β‐TCP) and amorphous calcium phosphate (ACP) are being used in areas of tissue defects. For this study, ACP was produced in the form of fibers and then submitted to cytotoxicity testing. A sample of ACP was inserted into the mandibular region of a patient with a lost implant so after removal and curettage, the remaining bone site was filled with the ACP biomaterial. Preliminary cytotoxicity test was negative. After 15 weeks of healing, a titanium implant was inserted at the site. Clinical and radiographic follow‐up was conducted for 12 months and sequential radiographic analyses revealed tissue formation resembling spongy bone. Images under immunohistochemistry demonstrated efficient deposition and osteoconduction of the newly deposited tissue. Residual portion of the CaO:P2O5 outer layers served as a substrate for osteoid matrix deposition, aiding growth, and the results of fiber absorption favored maturation of the new bone tissue.pt_BR
dc.format.extent579-589pt_BR
dc.identifier.citationALLEGRINI JUNIOR, SERGIO; SILVA, ANTONIO C. da; TSUJITA, MARISTELA; SALLES, MARCOS B.; GEHRKE, SERGIO A.; BRAGA, FRANCISCO J.C. Amorphous calcium phosphate (ACP) in tissue repair process. <b>Microscopy Research and Technique</b>, v. 81, n. 6, p. 579-589, 2018. DOI: <a href="https://dx.doi.org/10.1002/jemt.23013">10.1002/jemt.23013</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/28956.
dc.identifier.doi10.1002/jemt.23013pt_BR
dc.identifier.fasciculo6pt_BR
dc.identifier.issn1059-910Xpt_BR
dc.identifier.percentilfi35.26en
dc.identifier.percentilfiCiteScore46.25
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/28956
dc.identifier.vol81pt_BR
dc.relation.ispartofMicroscopy Research and Techniquept_BR
dc.rightsclosedAccesspt_BR
dc.subjecttoxicity
dc.subjectcalcium phosphates
dc.subjectimplants
dc.subjectamorphous state
dc.subjectsynthetic materials
dc.subjectbiological materials
dc.subjectin vitro
dc.subjectin vivo
dc.subjectbioassay
dc.subjectdentistry
dc.subjectteeth
dc.subjectbone tissues
dc.titleAmorphous calcium phosphate (ACP) in tissue repair processpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorFRANCISCO JOSE CORREA BRAGA
ipen.autorANTONIO CARLOS DA SILVA
ipen.codigoautor1087
ipen.codigoautor2949
ipen.contributor.ipenauthorFRANCISCO JOSE CORREA BRAGA
ipen.contributor.ipenauthorANTONIO CARLOS DA SILVA
ipen.date.recebimento18-07pt_BR
ipen.identifier.fi1.327pt_BR
ipen.identifier.fiCiteScore2.1
ipen.identifier.ipendoc24741pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi0.001 - 1.499
ipen.range.percentilfi25.00 - 49.99
ipen.type.genreArtigo
relation.isAuthorOfPublication5408ccfa-7c6c-46d2-b89b-06a18ac9eb9a
relation.isAuthorOfPublication839a3a2d-55ca-4376-993c-a8279c5cf017
relation.isAuthorOfPublication.latestForDiscovery839a3a2d-55ca-4376-993c-a8279c5cf017
sigepi.autor.atividadeSILVA, ANTONIO C. DA:2949:720:Npt_BR
sigepi.autor.atividadeBRAGA, FRANCISCO J.C.:1087:730:Npt_BR
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