[6]-Gingerol decreases clonogenicity and radioresistance of human prostate cancer cells
| dc.contributor.author | SILVA, J.P.L. | pt_BR |
| dc.contributor.author | TEIXEIRA, L.F. | pt_BR |
| dc.contributor.author | BELLINI, M.H. | pt_BR |
| dc.coverage | Internacional | pt_BR |
| dc.date.accessioned | 2020-02-21T12:15:24Z | |
| dc.date.available | 2020-02-21T12:15:24Z | |
| dc.date.issued | 2019 | pt_BR |
| dc.description.abstract | The phenolic compound [6]-Gingerol, isolated from Zingiber officinale, has been demonstrated to have antitumor activity for different types of malignant tumours. Prostate cancer is the most common malignancy among males worldwide, being the second leading cause of cancer death in men. In the present study, we investigated the antitumor action of [6]-Gingerol on a human prostate cancer cell line (LNCaP). Our data shows that [6]-Gingerol treatment induced a dose-dependent decrease in the cell viability. Compared with the vehicle control, the cell viabilities were 79.90 ± 3.56% and 53.06 ± 7.82% when the LNCaP cells were exposed to 150 μg/mL and 300 μg/mL of [6]-Gingerol, respectively. The treatment of LNCaP with 300 μM of [6]-Gingerol led to a significant reduction (~25%) on the clonogenic survival of these cells. Furthermore, [6]-gingerol acted as a radiosensitizer for LNCaP cells. The pretreatment of these cells with [6]-Gingerol significantly enhanced the killing effects of ionizing radiation with a dose enhancement ratio of 1.25. Our results demonstrate the anti-tumour activities of [6]-Gingerol. Further studies are needed to elucidate the mechanisms involved. | pt_BR |
| dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | pt_BR |
| dc.description.sponsorshipID | FAPESP: 14/19265-7 | pt_BR |
| dc.format.extent | 1-3 | pt_BR |
| dc.identifier.citation | SILVA, J.P.L.; TEIXEIRA, L.F.; BELLINI, M.H. [6]-Gingerol decreases clonogenicity and radioresistance of human prostate cancer cells. <b>Clinical Oncology and Research</b>, v. 2, n. 5, p. 1-3, 2019. DOI: <a href="https://dx.doi.org/10.31487/j.COR.2019.05.07">10.31487/j.COR.2019.05.07</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/30818. | |
| dc.identifier.doi | 10.31487/j.COR.2019.05.07 | pt_BR |
| dc.identifier.fasciculo | 5 | pt_BR |
| dc.identifier.issn | 2613-4942 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0003-2852-6189 | |
| dc.identifier.percentilfi | Sem Percentil | pt_BR |
| dc.identifier.percentilfiCiteScore | Sem Percentil CiteScore | |
| dc.identifier.uri | http://repositorio.ipen.br/handle/123456789/30818 | |
| dc.identifier.vol | 2 | pt_BR |
| dc.relation.ispartof | Clinical Oncology and Research | pt_BR |
| dc.rights | openAccess | pt_BR |
| dc.subject | prostate | |
| dc.subject | neoplasms | |
| dc.subject | radiosensitivity effects | |
| dc.subject | radiosensitizers | |
| dc.subject | radiosensitivity | |
| dc.subject | clone cells | |
| dc.subject | cloning | |
| dc.subject | viability | |
| dc.subject | medicinal plants | |
| dc.subject | spices | |
| dc.subject | radiotherapy | |
| dc.subject | tumor cells | |
| dc.title | [6]-Gingerol decreases clonogenicity and radioresistance of human prostate cancer cells | pt_BR |
| dc.type | Artigo de periódico | pt_BR |
| dspace.entity.type | Publication | |
| ipen.autor | MARIA HELENA BELLINI MARUMO | |
| ipen.autor | LUIZ FELIPE TEIXEIRA DA SILVA | |
| ipen.autor | JOSIAS PAULINO LEAL SILVA | |
| ipen.codigoautor | 1242 | |
| ipen.codigoautor | 14146 | |
| ipen.codigoautor | 14436 | |
| ipen.contributor.ipenauthor | MARIA HELENA BELLINI MARUMO | |
| ipen.contributor.ipenauthor | LUIZ FELIPE TEIXEIRA DA SILVA | |
| ipen.contributor.ipenauthor | JOSIAS PAULINO LEAL SILVA | |
| ipen.date.recebimento | 20-02 | |
| ipen.identifier.fi | Sem F.I. | pt_BR |
| ipen.identifier.fiCiteScore | Sem CiteScore | |
| ipen.identifier.ipendoc | 26646 | pt_BR |
| ipen.type.genre | Artigo | |
| relation.isAuthorOfPublication | 6a450cbf-91b1-4386-b4a8-7304afac99cc | |
| relation.isAuthorOfPublication | 1ccbe3d6-1fec-40ee-9090-54f8ccd43c4d | |
| relation.isAuthorOfPublication | de833761-f10b-4e7b-ae3e-9977c7fd06ce | |
| relation.isAuthorOfPublication.latestForDiscovery | de833761-f10b-4e7b-ae3e-9977c7fd06ce | |
| sigepi.autor.atividade | BELLINI, M.H.:1242:820:N | pt_BR |
| sigepi.autor.atividade | TEIXEIRA, L.F.:14146:820:N | pt_BR |
| sigepi.autor.atividade | SILVA, J.P.L.:14436:810:S | pt_BR |