Non-ablative treatment of sleep breathing disorders with the association of two high-intensity pulsed lasers

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dc.contributor.advisorDenise Maria Zezellpt_BR
dc.contributor.authorMENDES, VALERIApt_BR
dc.coverageNacionalpt_BR
dc.date.accessioned2023-03-10T13:28:29Z
dc.date.available2023-03-10T13:28:29Z
dc.date.issued2022pt_BR
dc.description.abstractPrimary snoring and obstructive sleep apnea (OSA) represent different severity degrees of the same chronic, complex and progressive disease, which affects about one billion people worldwide. It is more prevalent in elderly men. Historically, snoring is seen as a social problem, being considered the most benign form of sleep breathing disorders (SBD). Because of this, treatment is not prescribed. Snoring noise occurs as a result of soft tissue vibration in the region of upper airway (UA) greater constriction during sleep. Therapeutic options may involve medical treatments, use of devices, and surgical procedures. As for the results, all of them have limitations. Adherence to treatment and cases of relapse over time represent the greatest challenge in disease control. Increased cardiovascular risk, emergence of chronic diseases and use of medications result from worsening and disease progression. A dysregulation of palatopharyngeal muscle tone plays a significant role in this disorder. After determining the best irradiation conditions, this study aims to evaluate the treatment of SBD with high intensity non-ablative irradiation with two pulsed lasers: Nd:YAG laser (1064 nm) followed by Er:YAG laser (2940 nm), both from Fotona LightWalker platform, comparing results before and after the intervention. A controlled, randomized, double-blind clinical trial was performed with approval of the research ethics committee. Thirty volunteers that transitioned between primary snoring and moderate obstructive sleep apnea were treated in three sessions of non-ablative laser irradiation, with a 14-day interval between them. The upper airway lumen for airflow passage was analyzed by photographic record, according to modified Mallampati index. Oxyhemoglobin desaturation parameters, severity of snoring (noise amplitude and sleep time with snoring) as well as aspects of sleep quality were also evaluated. The main clinical result obtained is the expansion of the upper airways lumen by reduction of tissue compliance in an outpatient procedure. Therefore, improvement of sleep breathing disorder.pt_BR
dc.description.notasgeraisDissertação (Mestrado Profissional em Tecnologia das Radiações em Ciências da Saúde)pt_BR
dc.description.notasteseIPEN/D-MPpt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDCNPq: SISFOTON 440228/2021-2; INCT INFO 465763/2014-6pt_BR
dc.description.sponsorshipIDFAPESP: 17/50332-0pt_BR
dc.description.teseinstituicaoInstituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SPpt_BR
dc.format.extent198pt_BR
dc.identifier.citationMENDES, VALERIA. <b>Non-ablative treatment of sleep breathing disorders with the association of two high-intensity pulsed lasers</b>: Nd:YAG and Er:YAG. Orientador: Denise Maria Zezell. 2022. 198 f. Dissertação (Mestrado Profissional em Tecnologia das Radiações em Ciências da Saúde) - Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP, São Paulo. Disponível em: http://repositorio.ipen.br/handle/123456789/33853.
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/33853
dc.localSão Paulopt_BR
dc.rightsopenAccesspt_BR
dc.subjectrespiration
dc.subjectbreath
dc.subjectsleep
dc.subjectrespiratory system
dc.subjecttherapy
dc.subjectlasers
dc.subjectneodymium lasers
dc.subjecterbium compounds
dc.subjectwavelengths
dc.titleNon-ablative treatment of sleep breathing disorders with the association of two high-intensity pulsed laserspt_BR
dc.title.alternativeTratamento não-ablativo dos distúrbios respiratórios do sono com associação de dois lasers pulsados de alta intensidade: Nd:YAG e Er:YAGpt_BR
dc.typeDissertaçãopt_BR
dspace.entity.typePublication
ipen.autorVALERIA MENDES
ipen.codigoautor15427
ipen.contributor.ipenauthorVALERIA MENDES
ipen.date.recebimento23-03
ipen.identifier.ipendoc29487pt_BR
ipen.subtituloNd:YAG and Er:YAGpt_BR
ipen.type.genreDissertação
relation.isAuthorOfPublicationfba7e55f-50ec-4b06-b1ec-24ce936138ce
relation.isAuthorOfPublication.latestForDiscoveryfba7e55f-50ec-4b06-b1ec-24ce936138ce
sigepi.autor.atividadeMENDES, VALERIA:15427:920:Spt_BR
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