Galectin-3 regulates the expression of tumor glycosaminoglycans and increases the metastatic potential of breast cancer

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dc.contributor.authorPEREIRA, JONATHAS X.pt_BR
dc.contributor.authorSANTOS, SOFIA N. dospt_BR
dc.contributor.authorPEREIRA, THAIS C.pt_BR
dc.contributor.authorCABANEL, MARIANApt_BR
dc.contributor.authorCHAMMAS, ROGERpt_BR
dc.contributor.authorOLIVEIRA, FELIPE L. dept_BR
dc.contributor.authorBERNARDES, EMERSON S.pt_BR
dc.contributor.authorEL-CHEIKH, MARCIA C.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2020-02-28T14:01:31Z
dc.date.available2020-02-28T14:01:31Z
dc.date.issued2019pt_BR
dc.description.abstractGalectin-3 (Gal-3) is a multifunctional β-galactoside-binding lectin that once synthesized is expressed in the nucleus, cytoplasm, cell surface, and extracellular environment. Gal-3 plays an important role in breast cancer tumors due to its ability to promote interactions between cell-cell and cell-extracellular matrix (ECM) elements, increasing tumor survival and metastatic dissemination. Still, the mechanism by which Gal-3 interferes with tumor cell migration and metastasis formation is complex and not fully understood. Here, we showed that Gal-3 knockdown increased the migration ability of 4T1 murine breast cancer cells in vitro. Using the 4T1 orthotopic breast cancer spontaneous metastasis mouse model, we demonstrated that 4T1-derived tumors were significantly larger in the presence of Gal-3 (scramble) in comparison with Gal-3 knockdown 4T1-derived tumors. Nevertheless, Gal-3 knockdown 4T1 cells were outnumbered in the bone marrow in comparison with scramble 4T1 cells. Finally, we reported here a decrease in the content of cell-surface syndecan-1 and an increase in the levels of chondroitin sulfate proteoglycans such as versican in Gal-3 knockdown 4T1 cells both in vitro and in vivo. Overall, our findings establish that Gal-3 downregulation during breast cancer progression regulates cell-associated and tumor microenvironment glycosaminoglycans (GAGs)/proteoglycans (PG), thus enhancing the metastatic potential of tumor cells.pt_BR
dc.format.extent1-15pt_BR
dc.identifier.citationPEREIRA, JONATHAS X.; SANTOS, SOFIA N. dos; PEREIRA, THAIS C.; CABANEL, MARIANA; CHAMMAS, ROGER; OLIVEIRA, FELIPE L. de; BERNARDES, EMERSON S.; EL-CHEIKH, MARCIA C. Galectin-3 regulates the expression of tumor glycosaminoglycans and increases the metastatic potential of breast cancer. <b>Journal of Oncology</b>, v. 2019, p. 1-15, 2019. DOI: <a href="https://dx.doi.org/10.1155/2019/9827147">10.1155/2019/9827147</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/30836.
dc.identifier.doi10.1155/2019/9827147pt_BR
dc.identifier.issn1687-8450pt_BR
dc.identifier.orcid0000-0002-0029-7313pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0029-7313
dc.identifier.percentilfi22.746pt_BR
dc.identifier.percentilfiCiteScore23.00
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/30836
dc.identifier.vol2019pt_BR
dc.relation.ispartofJournal of Oncologypt_BR
dc.rightsopenAccesspt_BR
dc.subjectlectins
dc.subjecttumor cells
dc.subjectextracellular space
dc.subjectmammary glands
dc.subjectneoplasms
dc.subjectcell cycle
dc.subjectcell cultures
dc.subjectmetastases
dc.titleGalectin-3 regulates the expression of tumor glycosaminoglycans and increases the metastatic potential of breast cancerpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorEMERSON SOARES BERNARDES
ipen.autorSOFIA NASCIMENTO DOS SANTOS
ipen.codigoautor12099
ipen.codigoautor14464
ipen.contributor.ipenauthorEMERSON SOARES BERNARDES
ipen.contributor.ipenauthorSOFIA NASCIMENTO DOS SANTOS
ipen.date.recebimento20-02
ipen.identifier.fi2.206pt_BR
ipen.identifier.fiCiteScore1.4
ipen.identifier.ipendoc26663pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods3
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi0.00 - 24.99
ipen.type.genreArtigo
relation.isAuthorOfPublication8115c8bd-822c-4f5a-9f49-3c12570ed40a
relation.isAuthorOfPublicationab78881a-78eb-42be-a463-aaf80e70de3d
relation.isAuthorOfPublication.latestForDiscoveryab78881a-78eb-42be-a463-aaf80e70de3d
sigepi.autor.atividadeBERNARDES, EMERSON S.:12099:110:Npt_BR
sigepi.autor.atividadeSANTOS, SOFIA N. dos:14464:110:Npt_BR
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