Synthesis of high stable gold (198) nanoparticles for radiotherapy
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2017
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PAN AMERICAN CONGRESS OF NANOTECHNOLOGY, 1st
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Cancer has become a problem in the last years, is expect be diagnosed more than 500 000
new cases in 2017, only in Brazil, according to Brazilian Cancer Nacional Institute. Among
women breast cancer is the most common and among men the most representative is prostate
cancer, and although treatments for both cancers have been already developed, new methods
more efficient and that causes less damage to the patient are always being searched. Gold
nanoparticles (AuNps) have many different applications on chemistry, biology, medicine, etc;
their low reactivity and toxicity and high stability become it very interesting for bioapplications,
such as drugs delivery and biosensing. In this work, we had developed a new method to
prepare 198AuNps, from a leaf of gold bombed by neutrons, adapting Turkevich method, these
nanoparticles were modified with bovine serum albumin (BSA) and characterized by multiple
techniques, after 30 days (eleven half-life decays). This methodology was capable of generate
AuNps with almost 14 nm and Zeta potential higher than -37 mV, very stable. BSA can be used
for different applications, like a simple stabilizer or to increase cellular uptaking, but in our case
its chromophore groups were utilized to follow damages caused by radiation, as a sensor for
radiation damage, a dosimeter. Bellow are presented TEM image, Zeta potential measures and
fluorescence spectroscopy of the 198AuNps-BSA samples.
Como referenciar
SANTOS, JONNATAN J.; LEAL, JESSICA; DIAS, LUIS A.P.; TOMA, SERGIO H.; CORIO, PAOLA; ARAKI, KOITI; GENEZINI, FREDERICO A.; KATTI, KATTESH V.; LUGAO, ADEMAR B. Synthesis of high stable gold (198) nanoparticles for radiotherapy. In: PAN AMERICAN CONGRESS OF NANOTECHNOLOGY, 1st, 27-30 de novembro, 2017, Guarujá, SP. Abstract... Disponível em: http://repositorio.ipen.br/handle/123456789/29055. Acesso em: 10 May 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.