The effect of Ipomoea carnea on maternal reproductive outcomes and fetal and postnatal development in rats

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dc.contributor.authorGOTARDO, ANDRE T.pt_BR
dc.contributor.authorLIPPI, LUCIANA L.pt_BR
dc.contributor.authorVIOLIN, KALAN B.pt_BR
dc.contributor.authorBEVILACQUA, ESTELA M.A.F.pt_BR
dc.contributor.authorGORNIAK, SILVANA L.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2021-04-05T17:32:46Z
dc.date.available2021-04-05T17:32:46Z
dc.date.issued2021pt_BR
dc.description.abstractIpomoea carnea is a toxic plant found in Brazil and other tropical countries. The plant contains the alkaloids calystegines and swainsonine, which inhibit key cellular enzymes and cause systematic cell death. It is known that swainsonine is excreted in the amniotic fluid of dams exposed to the plant. Thus, the aim of this study was to verify whether the toxic effect of I. carnea on fetuses is due to exclusively the passage of the active principle of the plant through the placenta, or if the placentotoxic effect of swainsonine could collaborate in the adverse effects observed in the fetus. The teratogenic effects of exposure to the toxic principles of I. carnea were evaluated not only using the conventional protocol but also at later stages in the postnatal developmental period. Females were treated, from gestation day (GD) 6 until GD19, with 0.0, 1.0, 3.0 or 7.0 g/kg body weight of I. carnea dry leaves. The plant did not induce changes in reproductive performance or biochemical profile of the dams. Dams that received the highest dose of I. carnea showed cytoplasmic vacuolization in the liver, kidney and placental tissue. I. carnea promoted different lectin binding patterns in different areas of placental tissue. No fetal skeletal or visceral malformations was observed. The postnatal evaluation revealed a lower litter weight and a lower pup body weight one day after birth in the group that received the highest dose of I. carnea. Physical milestones were unaffected by the treatments. Female pups from all experimental groups exhibited a delay in achieving a negative geotaxis response. The results show that the toxic principle of I. carnea produces injury in utero in mothers and fetuses, but these deleterious effects were better demonstrated using postnatal evaluation.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 06/58728-6pt_BR
dc.format.extent3-10pt_BR
dc.identifier.citationGOTARDO, ANDRE T.; LIPPI, LUCIANA L.; VIOLIN, KALAN B.; BEVILACQUA, ESTELA M.A.F.; GORNIAK, SILVANA L. The effect of Ipomoea carnea on maternal reproductive outcomes and fetal and postnatal development in rats. <b>Toxicon</b>, v. 190, p. 3-10, 2021. DOI: <a href="https://dx.doi.org/10.1016/j.toxicon.2020.11.012">10.1016/j.toxicon.2020.11.012</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31963.
dc.identifier.doi10.1016/j.toxicon.2020.11.012pt_BR
dc.identifier.issn0041-0101pt_BR
dc.identifier.percentilfi36.90pt_BR
dc.identifier.percentilfiCiteScore54.00
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31963
dc.identifier.vol190pt_BR
dc.relation.ispartofToxiconpt_BR
dc.rightsopenAccesspt_BR
dc.subjecttoxicity
dc.subjectplants
dc.subjectreproduction
dc.subjectplacenta
dc.subjectfetuses
dc.subjectteratogens
dc.subjectalkaloids
dc.subjectbioassay
dc.subjecttropical regions
dc.titleThe effect of Ipomoea carnea on maternal reproductive outcomes and fetal and postnatal development in ratspt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorKALAN BASTOS VIOLIN
ipen.codigoautor9545
ipen.contributor.ipenauthorKALAN BASTOS VIOLIN
ipen.date.recebimento21-04
ipen.identifier.fi3.035pt_BR
ipen.identifier.fiCiteScore4.9
ipen.identifier.ipendoc27734pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi3.000 - 4.499
ipen.range.percentilfi25.00 - 49.99
ipen.type.genreArtigo
relation.isAuthorOfPublication7389e571-bcff-430b-914a-c528ef8a19d1
relation.isAuthorOfPublication.latestForDiscovery7389e571-bcff-430b-914a-c528ef8a19d1
sigepi.autor.atividadeVIOLIN, KALAN B.:9545:720:Npt_BR
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