Low dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in mice

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dc.contributor.authorGENARO, ISABELLA S. de
dc.contributor.authorALMEIDA, FRANCINE M. de
dc.contributor.authorHIZUME-KUNZLER, DEBORAH C.
dc.contributor.authorMORIYA, HENRIQUE T.
dc.contributor.authorSILVA, RONALDO A.
dc.contributor.authorCRUZ, JOAO C.G.
dc.contributor.authorLOPES, RENAN B.
dc.contributor.authorRIGHETTI, RENATO F.
dc.contributor.authorVIEIRA, RODOLFO de P.
dc.contributor.authorSAIKI, MITIKO
dc.contributor.authorMARTINS, MILTON A.
dc.contributor.authorTIBERIO, IOLANDA de F.L.C.
dc.contributor.authorARANTES-COSTA, FERNANDA M.
dc.contributor.authorSARAIVA-ROMANHOLO, BEATRIZ M.
dc.coverageInternacionalpt_BR
dc.date.accessioned2018-12-03T17:57:22Z
dc.date.available2018-12-03T17:57:22Z
dc.date.issued2018pt_BR
dc.description.abstractWork-exacerbated asthma (WEA) is defined as preexisting asthma that worsens with exposure to irritants [e.g., chlorine (Cl2) derivatives] in the workplace. The maximum allowable concentration in the workplace of Cl2 exposure is 3 mg/ m3 (described in OSHA). We investigated in an experimental asthma model in mice the effects of a single exposure to a sodium hypochlorite dose with this allowed chlorine concentration and a tenfold higher dose. Acute chlorine exposure at 3.3 mg/m3 in the OVA-sensitized group increased eosinophils in the peribronquial infiltrate, cytokine production, nasal mucus production and the number of iNOS positive cells in the distal lung compared to only sensitized mice. The exposure to a higher dose of 33.3 mg/m3 in the OVA-sensitized group resulted in an increase in respiratory system elastance, in the total and differential numbers of inflammatory cells in bronchoalveolar lavage fluid, IL-4, IL-5, and IL-17 in the lungs, eosinophils in peribronquial infiltrate and mucus content in nasal compared to non-exposed and sensitized animals. In this asthma model, chorine exposures at an allowable dose, contributed to the potentiation of Th2 responses. The functional alterations were associated with increased iNOS and ROCK-2 activation in the distal lung.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 09/53904-9; 12/15165-2; 18/20380-6pt_BR
dc.identifier.citationGENARO, ISABELLA S. de; ALMEIDA, FRANCINE M. de; HIZUME-KUNZLER, DEBORAH C.; MORIYA, HENRIQUE T.; SILVA, RONALDO A.; CRUZ, JOAO C.G.; LOPES, RENAN B.; RIGHETTI, RENATO F.; VIEIRA, RODOLFO de P.; SAIKI, MITIKO; MARTINS, MILTON A.; TIBERIO, IOLANDA de F.L.C.; ARANTES-COSTA, FERNANDA M.; SARAIVA-ROMANHOLO, BEATRIZ M. Low dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in mice. <b>Scientific Reports</b>, v. 8, n. 12636, 2018. DOI: <a href="https://dx.doi.org/10.1038/s41598-018-30851-6">10.1038/s41598-018-30851-6</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/29306.
dc.identifier.doi10.1038/s41598-018-30851-6pt_BR
dc.identifier.fasciculo12636pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.orcidaguardandopt_BR
dc.identifier.percentilfi78.99pt_BR
dc.identifier.percentilfiCiteScore92.00
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29306
dc.identifier.vol8pt_BR
dc.relation.ispartofScientific Reports
dc.rightsopenAccesspt_BR
dc.subjectchlorine
dc.subjectallergy
dc.subjectinflammation
dc.subjectlymphokines
dc.subjectnose
dc.subjectsinuses
dc.subjectrespiratory system diseases
dc.subjectasthma
dc.titleLow dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in micept_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorMITIKO SAIKI
ipen.codigoautor1178
ipen.contributor.ipenauthorMITIKO SAIKI
ipen.date.recebimento18-12pt_BR
ipen.identifier.fi4.011pt_BR
ipen.identifier.fiCiteScore6.4
ipen.identifier.ipendoc25095pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods3
ipen.observacoesAuthor Correction anexado. Scientific Reports, v. 8, p. 1, 2018. DOI: 10.1038/s41598-018-36667-8
ipen.range.fi3.000 - 4.499
ipen.range.percentilfi75.00 - 100.00
ipen.type.genreArtigo
relation.isAuthorOfPublication78e9df14-8ccf-4a31-a02f-4a8a4c111c14
relation.isAuthorOfPublication.latestForDiscovery78e9df14-8ccf-4a31-a02f-4a8a4c111c14
sigepi.autor.atividadeSAIKI, MITIKO:1178:320:Npt_BR
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