Effects of photobiomodulation on breast tumor-bearing mice

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dc.contributor.authorSILVA, CAMILA R.
dc.contributor.authorTOLEDO, SAULO P.
dc.contributor.authorRIBEIRO, MARTHA S.
dc.contributor.editorHAMBLIN, MICHAEL R.
dc.contributor.editorCARROLL, JAMES D.
dc.contributor.editorARANY, PRAVEEN
dc.coverageInternacionalpt_BR
dc.creator.eventoMECHANISMS OF PHOTOBIOMODULATION THERAPY, 13thpt_BR
dc.date.accessioned2019-02-07T12:57:58Z
dc.date.available2019-02-07T12:57:58Z
dc.date.eventoJanuary 27 - February 01, 2018pt_BR
dc.description.abstractPhotobiomodulation (PBM) has gained great prominence in health areas due to the search for less invasive treatments. However, its use is still not indicated in cancer patients due to lack of clarification about its effects on tumor cells. The aim of this work was to evaluate the effects of PBM on breast tumor-bearing mice. Nine BALB/c female mice (6 weeks old) received 2x106 breast cancer cells (4T1-Luc) into the mammary fat pad and after two weeks, when the tumor volume was about 0.1 cm3, the animals were divided into control (n=3), PBM30 and PBM150 groups. Test groups were submitted to PBM in a single session using a red laser (λ= 660 nm, 40 mW) with fluences of 30 J/cm² and 150 J/cm², respectively. The tumor progression was monitored by a caliper and bioimaging through bioluminescence of 4T1-Luc cells. The anti-fatigue effect of PBM was assessed by a forced swimming test. Our results showed that 3 weeks post-PBM, the lower fluence promoted an increase of the tumor volume compared to control with no treatment. On the other hand, the higher fluence was able to arrest tumor progression as well as increase the swimming time. Taken together, our results suggest that PBM triggers opposite effects on breast tumor-bearing mice depending on fluence used.pt_BR
dc.event.siglaSPIEpt_BR
dc.identifier.citationSILVA, CAMILA R.; TOLEDO, SAULO P.; RIBEIRO, MARTHA S. Effects of photobiomodulation on breast tumor-bearing mice. In: HAMBLIN, MICHAEL R. (ed.); CARROLL, JAMES D. (ed.); ARANY, PRAVEEN (ed.). In: MECHANISMS OF PHOTOBIOMODULATION THERAPY, 13th, January 27 - February 01, 2018, San Francisco, CA, USA. <b>Abstract...</b> Bellingham, WA, USA: Society of Photo-optical Instrumentation Engineers, 2018. (SPIE Proceedings Series, 10477). Disponível em: http://repositorio.ipen.br/handle/123456789/29500.
dc.identifier.orcidaguardandopt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4203-1134
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29500
dc.localBellingham, WA, USApt_BR
dc.local.eventoSan Francisco, CA, USApt_BR
dc.publisherSociety of Photo-optical Instrumentation Engineerspt_BR
dc.relation.ispartofseriesSPIE Proceedings Series, 10477pt_BR
dc.rightsopenAccesspt_BR
dc.titleEffects of photobiomodulation on breast tumor-bearing micept_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorSAULO DE TOLEDO PEREIRA
ipen.autorMARTHA SIMOES RIBEIRO
ipen.autorCAMILA RAMOS SILVA
ipen.codigoautor14728
ipen.codigoautor574
ipen.codigoautor11642
ipen.contributor.ipenauthorSAULO DE TOLEDO PEREIRA
ipen.contributor.ipenauthorMARTHA SIMOES RIBEIRO
ipen.contributor.ipenauthorCAMILA RAMOS SILVA
ipen.date.recebimento19-02pt_BR
ipen.event.datapadronizada2018pt_BR
ipen.identifier.ipendoc25288pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
relation.isAuthorOfPublication66ffed91-aa19-447b-ba42-d90487125c03
relation.isAuthorOfPublication36215a53-0150-4910-91d7-9559717b62d7
relation.isAuthorOfPublication7b89c9af-427d-4f2a-bb3d-1f6252c548c2
relation.isAuthorOfPublication.latestForDiscovery7b89c9af-427d-4f2a-bb3d-1f6252c548c2
sigepi.autor.atividadeSILVA, CAMILA R.:11642:920:Spt_BR
sigepi.autor.atividadeTOLEDO, SAULO P.:14728:920:Npt_BR
sigepi.autor.atividadeRIBEIRO, MARTHA S.:574:920:Npt_BR
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