Electron beam irradiation of combined pharmaceuticals

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dc.contributor.authorBOIANI, NATHALIA F.pt_BR
dc.contributor.authorGARCIA, VANESSA S.G.pt_BR
dc.contributor.authorBORRELY, SUELI I.pt_BR
dc.coverageNacionalpt_BR
dc.date.accessioned2021-08-12T14:55:23Z
dc.date.available2021-08-12T14:55:23Z
dc.date.issued2021pt_BR
dc.description.abstractThere are serious evidences that justify the search for treatment technologies or processes combination for the improvement of decomposition for dozens of pharmaceuticals in wastewaters. Electron beam irradiation may play an important role in this scenario and relatively low doses have been reported for such purposes. The aim of the present study was to evaluate the toxic response of the crustacean Daphnia similis exposed to individual and combined pharmaceuticals, before and after electron beam irradiation treatment. Several experimental trials of an acute immobilization test were performed with a mixture of pharmaceuticals composed of fluoxetine hydrochloride (Prozac®), and propranolol. Single pharmaceuticals were first tested separately. Toxicity of binary mixture was then assessed using five concentrations and five percentages of each substance in the mixture (0, 25, 50, 75, and 100%). Acute EC50% values ranged from 5.0 to 7.4 for fluoxetine and from 11.3 to 13.7 for propranolol. In mixture, values ranged from 6.4 to 9.8. Fluoxetine was more toxic than propranolol for D.similis. The different pharmaceuticals concentrations employed in a mixture showed no difference in toxicity values. When electron beam irradiation was applied, approximately 80% of acute effects were reduced at 5 kGy, and the mixture containing a higher percentage of fluoxetine, also showed a greater reduction of toxicity.pt_BR
dc.format.extent1-12pt_BR
dc.identifier.citationBOIANI, NATHALIA F.; GARCIA, VANESSA S.G.; BORRELY, SUELI I. Electron beam irradiation of combined pharmaceuticals: propranonol and fluoxetine and related ecotoxicity. <b>Brazilian Journal of Radiation Sciences</b>, v. 9, n. 1A, p. 1-12, 2021. DOI: <a href="https://dx.doi.org/10.15392/bjrs.v9i1A.1575">10.15392/bjrs.v9i1A.1575</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/32145.
dc.identifier.doi10.15392/bjrs.v9i1A.1575pt_BR
dc.identifier.fasciculo1Apt_BR
dc.identifier.issn2319-0612pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9692-5539
dc.identifier.percentilfiSem Percentilpt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/32145
dc.identifier.vol9pt_BR
dc.relation.ispartofBrazilian Journal of Radiation Sciencespt_BR
dc.rightsopenAccesspt_BR
dc.sourceMeeting on Nuclear Applications (ENAN), 14th, October 21-25, 2019, Santos, SPpt_BR
dc.subjectecological concentration
dc.subjectcrustaceans
dc.subjectenvironmental effects
dc.subjectenvironmental protection
dc.subjectwaste water
dc.subjectirradiation
dc.subjecttoxicity
dc.titleElectron beam irradiation of combined pharmaceuticalspt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorSUELI IVONE BORRELY
ipen.autorVANESSA SILVA GRANADEIRO GARCIA
ipen.autorNATHALIA FONSECA BOIANI
ipen.codigoautor150
ipen.codigoautor6046
ipen.codigoautor12769
ipen.contributor.ipenauthorSUELI IVONE BORRELY
ipen.contributor.ipenauthorVANESSA SILVA GRANADEIRO GARCIA
ipen.contributor.ipenauthorNATHALIA FONSECA BOIANI
ipen.date.recebimento21-08
ipen.identifier.fiSem F.I.pt_BR
ipen.identifier.ipendoc27915pt_BR
ipen.subtitulopropranonol and fluoxetine and related ecotoxicitypt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublication76171e20-c8ac-475f-9006-27402113c92f
relation.isAuthorOfPublicatione3a89769-eeae-4164-9096-2a1a10a42a34
relation.isAuthorOfPublication4a6f0d4a-15b9-410c-ac91-b72055559f15
relation.isAuthorOfPublication.latestForDiscovery4a6f0d4a-15b9-410c-ac91-b72055559f15
sigepi.autor.atividadeBORRELY, SUELI I.:150:220:Npt_BR
sigepi.autor.atividadeGARCIA, VANESSA S.G.:6046:220:Npt_BR
sigepi.autor.atividadeBOIANI, NATHALIA F.:12769:220:Spt_BR
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