Advanced design, simulation, and dosimetry of a novel rectal applicator for contact brachytherapy with a conventional HDR 192Ir source

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dc.contributor.authorBELLEZZO, MURILLOpt_BR
dc.contributor.authorFONSECA, GABRIEL P.pt_BR
dc.contributor.authorVONCKEN, ROBERTpt_BR
dc.contributor.authorVERRIJSSEN, AN-SOFIEpt_BR
dc.contributor.authorVAN BEVEREN, CELINEpt_BR
dc.contributor.authorROELOFS, ERIKpt_BR
dc.contributor.authorYORIYAZ, HELIOpt_BR
dc.contributor.authorRENIERS, BRIGITTEpt_BR
dc.contributor.authorVAN LIMBERGEN, EVERT J.pt_BR
dc.contributor.authorBERB EE, MAAIKEpt_BR
dc.contributor.authorVERHAEGEN, FRANKpt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2020-07-22T18:22:19Z
dc.date.available2020-07-22T18:22:19Z
dc.date.issued2020pt_BR
dc.description.abstractPURPOSE: Dose escalation yields higher complete response to rectal tumors, which may enable the omission of surgery. Dose escalation using 50 kVp contact x-ray brachytherapy (CXB) allow the treatment of a selective volume, resulting in low toxicity and organs-at-risk preservation. However, the use of CXB devices is limited because of its high cost and lack of treatment planning tools. Hence, the MAASTRO applicator (for HDR 192Ir sources) was developed and characterized by measurements and Monte Carlo simulations to be a cost-effective alternative to CXB devices. METHODS AND MATERIALS: A cylindrical applicator with lateral shielding was designed to be used with a rectoscope using its tip as treatment surface. Both the applicator and the rectoscope have a slanted edge to potentially allow easier placement against tumors. The applicator design was achieved by Monte Carlo modeling and validated experimentally with film dosimetry, using the Papillon 50 (P50) device as reference. RESULTS: The applicator delivers CXB doses in less than 9 min using a 20375 U source for a treatment area of approximately 20 20 mm2 at 2 mm depth. Normalized at 2 mm, the dose falloff for depths of 0 mm, 5 mm, and 10 mm are 130%, 70%, and 43% for the P50 and 140%, 67%, and 38% for the MAASTRO applicator, respectively. CONCLUSIONS: The MAASTRO applicator was designed to use HDR 192Ir sources to deliver a dose distribution similar to those of CXB devices. The applicator may provide a cost-effective solution for endoluminal boosting with clinical treatment planning system integration.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipIDCNPq: 200402/2015-3pt_BR
dc.format.extent544-553pt_BR
dc.identifier.citationBELLEZZO, MURILLO; FONSECA, GABRIEL P.; VONCKEN, ROBERT; VERRIJSSEN, AN-SOFIE; VAN BEVEREN, CELINE; ROELOFS, ERIK; YORIYAZ, HELIO; RENIERS, BRIGITTE; VAN LIMBERGEN, EVERT J.; BERB EE, MAAIKE; VERHAEGEN, FRANK. Advanced design, simulation, and dosimetry of a novel rectal applicator for contact brachytherapy with a conventional HDR 192Ir source. <b>Brachytherapy</b>, v. 19, n. 4, p. 544-553, 2020. DOI: <a href="https://dx.doi.org/10.1016/j.brachy.2020.03.009">10.1016/j.brachy.2020.03.009</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31351.
dc.identifier.doi10.1016/j.brachy.2020.03.009pt_BR
dc.identifier.fasciculo4pt_BR
dc.identifier.issn1538-4721pt_BR
dc.identifier.orcid0000-0003-4023-236Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4023-236X
dc.identifier.percentilfi23.98pt_BR
dc.identifier.percentilfiCiteScore56.50
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31351
dc.identifier.vol19pt_BR
dc.relation.ispartofBrachytherapypt_BR
dc.rightsopenAccesspt_BR
dc.subjectbrachytherapy
dc.subjectmonte carlo method
dc.subjectrectal administration
dc.subjectiridium 192
dc.subjectdose rates
dc.subjectradiation sources
dc.subjectsimulation
dc.subjectradiotherapy
dc.subjectneoplasms
dc.subjectfilm dosimetry
dc.titleAdvanced design, simulation, and dosimetry of a novel rectal applicator for contact brachytherapy with a conventional HDR 192Ir sourcept_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorMURILLO BELLEZZO
ipen.autorHELIO YORIYAZ
ipen.codigoautor10246
ipen.codigoautor80
ipen.contributor.ipenauthorMURILLO BELLEZZO
ipen.contributor.ipenauthorHELIO YORIYAZ
ipen.date.recebimento20-07
ipen.identifier.fi2.362pt_BR
ipen.identifier.fiCiteScore3.8
ipen.identifier.ipendoc27125pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi0.00 - 24.99
ipen.type.genreArtigo
relation.isAuthorOfPublicationfbb6d3c2-9f6b-43d0-947e-d4de7792bee3
relation.isAuthorOfPublication93102dac-f89d-4743-b6ea-5158708cbb92
relation.isAuthorOfPublication.latestForDiscoveryfbb6d3c2-9f6b-43d0-947e-d4de7792bee3
sigepi.autor.atividadeYORIYAZ, HELIO:80:420:Npt_BR
sigepi.autor.atividadeBELLEZZO, MURILLO:10246:420:Spt_BR
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