Antimicrobial activity and physicochemical performance of a modified endodontic sealer

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dc.contributor.authorGONCALVES, FLAVIApt_BR
dc.contributor.authorCAMPOS, LUIZA M. de P.pt_BR
dc.contributor.authorSANCHES, LUCIANA K.F.pt_BR
dc.contributor.authorSILVA, LARISSA T.S.pt_BR
dc.contributor.authorSANTOS, TAMIRIS M.R. dospt_BR
dc.contributor.authorVARCA, GUSTAVO H.C.pt_BR
dc.contributor.authorLOPES, DIANA P.pt_BR
dc.contributor.authorCOGO-MULLER, KARINApt_BR
dc.contributor.authorPARRA, DUCLERC F.pt_BR
dc.contributor.authorBRAGA, ROBERTO R.pt_BR
dc.contributor.authorSANTOS, MARCELO dospt_BR
dc.contributor.authorBOARO, LETICIA C.C.pt_BR
dc.coverageNacionalpt_BR
dc.date.accessioned2021-02-24T19:43:25Z
dc.date.available2021-02-24T19:43:25Z
dc.date.issued2020pt_BR
dc.description.abstractIntroduction: this study aimed to evaluate the antimicrobial and physicochemical properties of a commercial endodontic sealer modified by the addition of montmorillonite (MMT) nanoparticles loaded with two different drugs: chlorhexidine (CHX) or metronidazole (MET). Methods: 5 wt% MMT/CHX or MMT/MET nanoparticles were added to the sealer AH-Plus. The experimental materials were evaluated for drug release, antimicrobial activity, flow, flexural strength, and flexural modulus. Data were subjected to one-way ANOVA, Kruskal-Wallis, and Mann-Whitney tests. Results: The drug incorporation into MMT particles was 9% and 10% for CHX and MET, respectively. At 20 days after manipulation, 16.5% of the drug was released by the sealer with MMT/MET and 0.4% by MMT/CHX. The addition of both nanoparticles decreased the flow of materials, but they were still in compliance with ISO 6876-2012. The conversion, flexural strength, and flexural modulus of MMT/MET (87%, 37±7 MPa, 2.3 GPa) and MMT/CHX (78%, 29±2 MPa, 2.7 GPa) were similar in both groups but lower than in the control group (100%, 54±7 MPa, 4.0±0.7 GPa). Both experimental materials were able to form an inhibition halo for E. faecalis bacteria (CHX: 4.8±1.4 and MET: 4.0±1.6 mm), whereas the control group did not inhibit the microorganism. Conclusion: both formulations proposed as endodontic sealer presented effective antimicrobial activity and acceptable flow. The addition of MMT/CHX and MMT/MET particles decreased the conversion and mechanical properties, but further studies are required to clarify the clinical relevance of these properties.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 16/01319-9pt_BR
dc.format.extent1-16pt_BR
dc.identifier.citationGONCALVES, FLAVIA; CAMPOS, LUIZA M. de P.; SANCHES, LUCIANA K.F.; SILVA, LARISSA T.S.; SANTOS, TAMIRIS M.R. dos; VARCA, GUSTAVO H.C.; LOPES, DIANA P.; COGO-MULLER, KARINA; PARRA, DUCLERC F.; BRAGA, ROBERTO R.; SANTOS, MARCELO dos; BOARO, LETICIA C.C. Antimicrobial activity and physicochemical performance of a modified endodontic sealer. <b>Research, Society and Development</b>, v. 9, n. 11, p. 1-16, 2020. DOI: <a href="https://dx.doi.org/10.33448/rsd-v9i11.9401">10.33448/rsd-v9i11.9401</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31816.
dc.identifier.doi10.33448/rsd-v9i11.9401pt_BR
dc.identifier.fasciculo11pt_BR
dc.identifier.issn2525-3409pt_BR
dc.identifier.orcid0000-0002-6481-0155pt_BR
dc.identifier.orcid0000-0002-6545-237Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7626-880X
dc.identifier.percentilfiSem Percentilpt_BR
dc.identifier.percentilfiCiteScoreSem Percentil CiteScore
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31816
dc.identifier.vol9pt_BR
dc.relation.ispartofResearch, Society and Developmentpt_BR
dc.rightsopenAccesspt_BR
dc.subjectantimicrobial agents
dc.subjectmetronidazole
dc.subjectorganic chlorine compounds
dc.subjectdentistry
dc.subjectdrugs
dc.subjectsealing materials
dc.subjectmontmorillonite
dc.subjectnanoparticles
dc.subjectteeth
dc.subjectseals
dc.titleAntimicrobial activity and physicochemical performance of a modified endodontic sealerpt_BR
dc.title.alternativeAtividade antimicrobiana e desempenho físico-químico de um cimento endodôntico modificadopt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorDUCLERC FERNANDES PARRA
ipen.autorGUSTAVO HENRIQUE COSTAVARCA
ipen.autorTAMIRIS MARTINS RIBEIRO DOS SANTOS
ipen.autorLUIZA MELLO DE PAIVA CAMPOS
ipen.codigoautor562
ipen.codigoautor8661
ipen.codigoautor14099
ipen.codigoautor7219
ipen.contributor.ipenauthorDUCLERC FERNANDES PARRA
ipen.contributor.ipenauthorGUSTAVO HENRIQUE COSTAVARCA
ipen.contributor.ipenauthorTAMIRIS MARTINS RIBEIRO DOS SANTOS
ipen.contributor.ipenauthorLUIZA MELLO DE PAIVA CAMPOS
ipen.date.recebimento21-02
ipen.identifier.fiSem F.I.pt_BR
ipen.identifier.fiCiteScoreSem CiteScore
ipen.identifier.ipendoc27589pt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublication67996d86-0a59-4ba2-8d38-facaa14e26c3
relation.isAuthorOfPublication46f998cf-b207-4854-94c0-dd2def4eec2a
relation.isAuthorOfPublicationc06d7646-75bd-4817-9d03-1bd939c91c1f
relation.isAuthorOfPublication36f6b8d9-59dd-4b20-a90b-22fed2c352f2
relation.isAuthorOfPublication.latestForDiscovery36f6b8d9-59dd-4b20-a90b-22fed2c352f2
sigepi.autor.atividadePARRA, DUCLERC F.:562:740:Npt_BR
sigepi.autor.atividadeVARCA, GUSTAVO H.C.:8661:740:Npt_BR
sigepi.autor.atividadeSANTOS, TAMIRIS M.R. dos:14099:740:Npt_BR
sigepi.autor.atividadeCAMPOS, LUIZA M. de P.:7219:750:Npt_BR
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