Evaluation of the toxicity of gold nanoparticles produced by green nanotechnology in Zebrafish (Danio rerio)

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dc.contributor.authorCAVALCANTE, A.K.pt_BR
dc.contributor.authorBATISTA, J.G.S.pt_BR
dc.contributor.authorMAZIERO, J.S.pt_BR
dc.contributor.authorDAMASCENO, K.C.pt_BR
dc.contributor.authorORMENIO, M.B.pt_BR
dc.contributor.authorCAVALCANTE, B.K.pt_BR
dc.contributor.authorROGERO, S.O.pt_BR
dc.contributor.authorROGERO, J.R.pt_BR
dc.contributor.authorLUGAO, A.B.pt_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoWORKSHOP ON ENVIRONMENTAL NANOTECHNOLOGY, 3rdpt_BR
dc.date.accessioned2019-08-23T19:37:03Z
dc.date.available2019-08-23T19:37:03Z
dc.date.eventoOctober 5-8, 2018pt_BR
dc.description.abstractGold nanoparticles (AuNPs) of different sizes and shapes have been extensively studied by researchers and laboratories around the world. Several studies have demonstrated the applicability of gold nanoparticles in the treatment and diagnosis of cancer, in the treatment of chronic inflammation, infections, degenerative diseases and autoimmune diseases [1]. The synthesis of AuNPs generally involves reducing agents which present problems related to toxicity. In order to address this issue, metabolites present in various plant extracts have been exploited for the preparation of different nanoparticles. The methods that use phytochemicals to reduce metal ions provide a green approach to nanotechnology, known as green nanotechnology [2]. Researchers have shown that some phytochemicals, such as mangiferin (MGF) and epigallocatechin-gallate (EGCG), in addition to reducing and stabilizing the gold nanoparticles, are able to functionalize them. These molecules have chemical groups that allow binding to overexpressed receptors on some types of tumor cells [3]. The objective of this study was to evaluate the level of toxicity of the gold nanoparticles, reduced and stabilized with epigallocatechin-gallate (EGCG-AuNPs) in Zebrafish embryos (Danio rerio), as an indication of a possible environmental effect. To assess the developmental impact of embryos, organisms were exposed to different dilutions of the EGCG-AuNPs suspension for a 96-hour period according to OECD Protocol 236 (Fish Embryo Acute Toxicity Test-FET). Zebrafish is an established vertebrate model for the study of development, disease and is being increasingly used for both pre-clinical studies and toxicological applications due to a range of favorable traits [4]. EGCG-AuNPs demonstrated toxicity, with organ lethality being less than 33% at all concentrations used. The work provided a contribution on the toxicity of AuNPs synthesized and stabilized with the epigallocatechin-gallate reducing agent and using Zebrafish embryos as an animal.pt_BR
dc.format.extent28-28pt_BR
dc.identifier.citationCAVALCANTE, A.K.; BATISTA, J.G.S.; MAZIERO, J.S.; DAMASCENO, K.C.; ORMENIO, M.B.; CAVALCANTE, B.K.; ROGERO, S.O.; ROGERO, J.R.; LUGAO, A.B. Evaluation of the toxicity of gold nanoparticles produced by green nanotechnology in Zebrafish (Danio rerio). In: WORKSHOP ON ENVIRONMENTAL NANOTECHNOLOGY, 3rd, October 5-8, 2018, Sorocaba, SP. <b>Abstract...</b> p. 28-28. Disponível em: http://repositorio.ipen.br/handle/123456789/30122.
dc.identifier.orcid0000-0002-1737-3191pt_BR
dc.identifier.orcid0000-0002-2517-7772pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.orcidhttps://orcid.org/0000-0002-2517-7772
dc.identifier.orcidhttps://orcid.org/0000-0003-3396-6277
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/30122
dc.local.eventoSorocaba, SPpt_BR
dc.rightsopenAccesspt_BR
dc.titleEvaluation of the toxicity of gold nanoparticles produced by green nanotechnology in Zebrafish (Danio rerio)pt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorJORGE GABRIEL DOS SANTOS BATISTA
ipen.autorJOANA DA SILVA MAZIERO
ipen.autorMATHEUS BEANI ORMENIO
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorJOSE ROBERTO ROGERO
ipen.autorSIZUE OTA ROGERO
ipen.autorBEATRIZ KUCHINSKI CAVALCANTE
ipen.autorKELME CARDOSO DAMASCENO
ipen.autorADRIANA KUCHINSKI CAVALCANTE
ipen.codigoautor10274
ipen.codigoautor14163
ipen.codigoautor14332
ipen.codigoautor339
ipen.codigoautor1118
ipen.codigoautor1266
ipen.codigoautor14882
ipen.codigoautor14173
ipen.codigoautor12073
ipen.contributor.ipenauthorJORGE GABRIEL DOS SANTOS BATISTA
ipen.contributor.ipenauthorJOANA DA SILVA MAZIERO
ipen.contributor.ipenauthorMATHEUS BEANI ORMENIO
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorJOSE ROBERTO ROGERO
ipen.contributor.ipenauthorSIZUE OTA ROGERO
ipen.contributor.ipenauthorBEATRIZ KUCHINSKI CAVALCANTE
ipen.contributor.ipenauthorKELME CARDOSO DAMASCENO
ipen.contributor.ipenauthorADRIANA KUCHINSKI CAVALCANTE
ipen.date.recebimento19-08
ipen.event.datapadronizada2018pt_BR
ipen.identifier.ipendoc25916pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
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sigepi.autor.atividadeLUGAO, A.B.:339:740:Npt_BR
sigepi.autor.atividadeROGERO, J.R.:1118:740:Npt_BR
sigepi.autor.atividadeROGERO, S.O.:1266:740:Npt_BR
sigepi.autor.atividadeCAVALCANTE, B.K.:14882:-1:Npt_BR
sigepi.autor.atividadeORMENIO, M.B.:14332:740:Npt_BR
sigepi.autor.atividadeDAMASCENO, K.C.:14173:740:Npt_BR
sigepi.autor.atividadeMAZIERO, J.S.:14163:740:Npt_BR
sigepi.autor.atividadeBATISTA, J.G.S.:10274:740:Npt_BR
sigepi.autor.atividadeCAVALCANTE, A.K.:12073:750:Spt_BR
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