Early expression of the aflatoxin gene cluster in Aspergillus nomiae isolated from Brazil nut

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dc.contributor.authorREIS, T.A.pt_BR
dc.contributor.authorTRALAMAZZA, S.M.pt_BR
dc.contributor.authorCOELHO, E.pt_BR
dc.contributor.authorZORZETE, P.pt_BR
dc.contributor.authorFAVARO, D.I.T.pt_BR
dc.contributor.authorCORREA, B.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2022-05-04T15:29:32Z
dc.date.available2022-05-04T15:29:32Z
dc.date.issued2022pt_BR
dc.description.abstractAspergillus nomiae is the most important contaminant in Brazil nut due to its high incidence in these nuts and its strong production of carcinogenic metabolites: aflatoxins (AF). Aflatoxin biosynthesis pathway in A. nomiae is poorly studied. Thus, in present investigation, aflatoxin production and gene cluster (aflC, aflQ, aflU, and aflX) expression profile were evaluated on two strains of A. nomiae isolated from Brazil nut samples collected in the Amazon region, and cultivated on Brazil nut-based medium. The results showed that the expression of the aflatoxin gene cluster in A. nomiae, started at day 2 and occurred before the production of aflatoxins. Aflatoxin production (AFB1 and AFG1) was detected on day 3 on both strains. From day 4 onwards, all four toxins were detected and their production kept at similar proportions (AFG1>AFB1>AFG2>AFB2). Thus, the anticipated information obtained through early expression profile results of aflC, aflQ, aflU, and aflX gene cluster in A. nomiae may foresee aflatoxin production before its detection in Brazil nuts.pt_BR
dc.format.extent36-42pt_BR
dc.identifier.citationREIS, T.A.; TRALAMAZZA, S.M.; COELHO, E.; ZORZETE, P.; FAVARO, D.I.T.; CORREA, B. Early expression of the aflatoxin gene cluster in Aspergillus nomiae isolated from Brazil nut. <b>Toxicon</b>, v. 209, p. 36-42, 2022. DOI: <a href="https://dx.doi.org/10.1016/j.toxicon.2022.01.008">10.1016/j.toxicon.2022.01.008</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/33031.
dc.identifier.doi10.1016/j.toxicon.2022.01.008pt_BR
dc.identifier.issn0041-0101pt_BR
dc.identifier.orcid0000-0002-0083-2523pt_BR
dc.identifier.percentilfi39pt_BR
dc.identifier.percentilfiCiteScore53pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/33031
dc.identifier.vol209pt_BR
dc.relation.ispartofToxiconpt_BR
dc.rightsopenAccesspt_BR
dc.subjectnuts
dc.subjectgenes
dc.subjectaspergillus
dc.subjectaflatoxins
dc.subjectbiosynthesis
dc.subjectgene regulation
dc.subjectmycotoxins
dc.titleEarly expression of the aflatoxin gene cluster in Aspergillus nomiae isolated from Brazil nutpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorDEBORAH INES TEIXEIRA FAVARO
ipen.codigoautor1374
ipen.contributor.ipenauthorDEBORAH INES TEIXEIRA FAVARO
ipen.date.recebimento22-05
ipen.identifier.fi2.8pt_BR
ipen.identifier.fiCiteScore5pt_BR
ipen.identifier.ipendoc28690pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi25.00 - 49.99
ipen.type.genreArtigo
relation.isAuthorOfPublication2c3aeafc-6cda-4a61-a4e3-43e60ff8dd2d
relation.isAuthorOfPublication.latestForDiscovery2c3aeafc-6cda-4a61-a4e3-43e60ff8dd2d
sigepi.autor.atividadeFAVARO, D.I.T.:1374:320:Npt_BR
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