Treatment of a burn animal model with functionalized tridimensional electrospun biomaterials

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dc.contributor.authorSTEFFENS, DANIELA
dc.contributor.authorMATHOR, MONICA B.
dc.contributor.authorSOSTER, PAULA R. da L.
dc.contributor.authorVERGANI, GUSTAVO
dc.contributor.authorLUCO, DAYANE P.
dc.contributor.authorPRANKE, PATRICIA
dc.coverageInternacionalpt_BR
dc.date.accessioned2018-02-22T13:55:07Z
dc.date.available2018-02-22T13:55:07Z
dc.date.issued2017pt_BR
dc.description.abstractLaminin-functionalized poly-D,L-lactic acid scaffolds were produced. Following this, mesenchymal stem cells and keratinocytes were seeded on biomaterials for the in vivo experiments, where the biomaterials with or without cells were implanted. The analysis is comprised of the visual aspect and mean size of the lesion plus the histology and gene expression. The results showed that the cells occupied all the structure of the scaffolds in all the groups. After nine days of in vivo experiments, the defect size did not show statistical difference among the groups, although the groups with the poly-D,L-lactic acid/Lam biomaterial had the lowest lesion size and presented the best visual aspect of the wound. Gene expression analysis showed considerable increase of tumor growth factor beta 1 expression, increased vascular endothelial growth factor and balance of the BAX/Bcl-2 ratio when compared to the lesion group. Histological analysis showed well-formed tissue in the groups where the biomaterials and biomaterials plus cells were used. In some animals, in which biomaterials and cells were used, the epidermis was formed throughout the length of the wound. In conclusion, these biomaterials were found to be capable of providing support for the growth of cells and stimulated the healing of the skin, which was improved by the use of cells.pt_BR
dc.format.extent663-676pt_BR
dc.identifier.citationSTEFFENS, DANIELA; MATHOR, MONICA B.; SOSTER, PAULA R. da L.; VERGANI, GUSTAVO; LUCO, DAYANE P.; PRANKE, PATRICIA. Treatment of a burn animal model with functionalized tridimensional electrospun biomaterials. <b>Journal of Biomaterials Applications</b>, v. 32, n. 5, p. 663-676, 2017. DOI: <a href="https://dx.doi.org/10.1177/0885328217735933">10.1177/0885328217735933</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/28535.
dc.identifier.doi10.1177/0885328217735933pt_BR
dc.identifier.fasciculo5pt_BR
dc.identifier.issn0885-3282pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-7294-9106
dc.identifier.percentilfi39.48en
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/28535
dc.identifier.vol32pt_BR
dc.relation.ispartofJournal of Biomaterials Applicationspt_BR
dc.rightsopenAccesspt_BR
dc.subjectburns
dc.subjectbiological materials
dc.subjectstem cells
dc.subjectkeratin
dc.subjectanimal tissues
dc.subjectskin
dc.subjectskin damage
dc.subjectelectrodes
dc.titleTreatment of a burn animal model with functionalized tridimensional electrospun biomaterialspt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorMONICA BEATRIZ MATHOR
ipen.codigoautor209
ipen.contributor.ipenauthorMONICA BEATRIZ MATHOR
ipen.date.recebimento18-02pt_BR
ipen.identifier.fi2.082pt_BR
ipen.identifier.ipendoc24384pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi25.00 - 49.99
ipen.type.genreArtigo
relation.isAuthorOfPublication742b424f-9dfb-4e4a-993b-000052bb1313
relation.isAuthorOfPublication.latestForDiscovery742b424f-9dfb-4e4a-993b-000052bb1313
sigepi.autor.atividadeMATHOR, MONICA B.:209:240:Npt_BR
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