HTA in nuclear medicine
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2019
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Clinical and Translational Imaging
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The [
68Ga]PSMA PET/CT has been an option on clinical research tools to stage and to restage prostate cancer patients,
although, with promising results, this radiopharmaceutical cannot be commercialized yet. Hence, up to date, [
68Ga]PSMA
has been used in a clinical research context. Once regulatory body approved it for marketing, health systems are responsible
for the reimbursement decision. Health Technology Assessments (HTA) tools should be considered to base and to help
decision-makers to spread or not this new technology. Regarding [
68Ga]PSMA, under HTA framework, the present study
searched for secondary studies and hence assessed three systematic reviews with meta-analyses published considering prostate
cancer patients in different scenarios, same imaging technology but different comparators and outputs. The secondary
studies considered outputs such as accuracy, detectability, positivity and change of management. Using AMSTAR-2, the
meta-analysis methods and results were evaluated with 16 questions able to identify critical weaknesses, such as risk of bias,
publication bias, true effect, and study heterogeneity. To increase the observational number of patients, to register positive and
negative findings, and consolidate regional and multi-center clinical data which were suggestions on study design, structure
and statistics made to improve the quality in future primary and secondary studies.
Como referenciar
POZZO, LORENA; MONTEIRO, LUCILENA R.; CERCI, JULIANA J.; FANTI, STEFANO; NEGRO, ANTONELLA; TRINDADE, EVELINDA. HTA in nuclear medicine: [Ga-68]PSMA PET/CT for patients with prostate cancer. Clinical and Translational Imaging, v. 7, n. 1, p. 7-20, 2019. DOI: 10.1007/s40336-019-00313-8. Disponível em: http://repositorio.ipen.br/handle/123456789/30065. Acesso em: 26 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.