A single application of low-level light therapy in breast cancer-bearing mice
Carregando...
Data
2020
Data de publicação:
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Lasers in Medical Science
Exportar
Resumo
Low-level light therapy (LLLT) has been used in healthcare as a therapeutic
strategy for diseases of various aetiologies. However, its effects on
cancer is controversial. The aim of this work was to evaluate the effects of
different light doses on blood cell count of breast cancer-bearing mice
after a single application of LLLT. Tumour was induced by inoculation of
4T1 cells into the mammary fat pad of female BALB/c mice. Tumour
volume was monitored with a digital calliper and when it reached 100
mm3, animals were irradiated by a red LED irradiator (660 ± 20 nm) at
irradiance of 24.3 mW/cm2. The animals were randomly divided into
groups (n= 5/group) that received energy densities of 1.8, 5.6 and 9.4
J/cm2. Control group was equally manipulated but did not receive irradiation.
After treatment, data as tumour volume, platelets, white and red cell
levels were registered weekly during 21 days. Our results showed that
irradiated groups presented a longer survival compared to the control
group, although no significant differences were observed among groups
regarding tumour volume. Platelet levels of the irradiated groups
remained closer to the reference values of healthy animals. Regarding
the total number of white and red cells, no significant differences were
observed between control and treated groups. These findings indicate that
LLLT in a single application did not arrest tumour growth but may maintain
platelet levels to increase survival of mice regardless the energy
density protocol used.
Como referenciar
PEREIRA, S.T.; SILVA, C.R.; RIBEIRO, M.S. A single application of low-level light therapy in breast cancer-bearing mice: impact on blood cell count. Lasers in Medical Science, v. 35, n. 1, p. 274-274, 2020. DOI: 10.1007/s10103-019-02900-7. Disponível em: http://repositorio.ipen.br/handle/123456789/31109. Acesso em: 04 May 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.