Leakage test methodology development in iodine-125 seeds production
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2013
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Progress in Nuclear Energy
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Brachytherapy using iodine-125 seeds has been used in prostate cancer treatment. In the quality control
routine during seed production, leakage tests are taken to detect any leakage of radioactive material from
inside the titanium shield, avoiding patient contamination. Leakage tests are carried out according to the
International Standard Organization e Radiation protection e sealed radioactive sources e ISO 9978.
This standard recommends different methods of essay applied to radioactive seeds. The aims of this work
were the study of the different leakage test methods applied to radioactive seeds recommended by the
ISO 9978 and the choice of the appropriate method to be used in the seeds production. The authors
evaluated five different immersion methods to detect leakage, following the standard guidance, and in
some case exceeding its requirement. One hundred iodine-125 seeds were intentionally cuted, causing
the release of its content. Each immersion method was applied to twenty seeds. After the immersion
period, the resulting liquid activity was measured. The activity values measured in the immersion liquid
indicated best results with distilled water as immersion liquid and with the application of ultrasound to
the bath. The temperature of the bath ranged from 20 C to 70 C and the immersion time ranged from
30 min to 24 h. In this experiment, the use of scintillator liquid as immersion liquid was not effective to
detect the leakage. The results allow the authors to choose the best methods to be applied in the
production routine, to detect leakage in the seeds. The choice of the method will also depend on the
production rhythm for schedule. In a moderate production rate, the test at 20 C and 24 h immersion
may be used. In a fast production rhythm, the shortest test 50 C or 70 C should be used.
Como referenciar
MOURA, JOAO A.; SOUZA, CARLA D. de; ROSTELATO, MARIA E.C.M.; MOURA, EDUARDO S. de; SPRENGER, FRANCISCO E.; NAGATOMI, HELIO R.; ZEITUNI, CARLOS A.; FEHER, ANSELMO; MANZOLI, JOSE E. Leakage test methodology development in iodine-125 seeds production. Progress in Nuclear Energy, v. 62, p. 79-82, 2013. DOI: 10.1016/j.pnucene.2012.09.011. Disponível em: http://repositorio.ipen.br/handle/123456789/4025. Acesso em: 10 May 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.