MARIA EDUARDA ZAGANIN RIGO

MARIA EDUARDA ZAGANIN RIGO

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Radioactive gold nanoparticles coated with BSA
2024 - BARBEZAN, ANGELICA B.; ROSERO, WILMMER A.A.; VIEIRA, DANIEL P.; RIGO, MARIA E.Z.; SILVA, GIOVANA D. da; RODRIGUES, ALEX A.; ALMEIDA, LUIS F. de; SILVA, FABIO F.A. da; RIVERA, ANDY G.; SILVA, NATANAEL G. da; BERNARDES, EMERSON S.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.
Background: Nanotechnology has revolutionized medicine, especially in oncological treatments. Gold nanoparticles (AuNPs) stand out as an innovative alternative due to their biocompatibility, potential for surface modification, and effectiveness in radiotherapeutic techniques. Given that prostate cancer ranks as one of the leading malignancies among men, there's a pressing need to investigate new therapeutic approaches. Methods: AuNPs coated with bovine serum albumin (BSA) were synthesized and their cytotoxicity was assessed against prostate tumor cell lines (LNCaP and PC-3), healthy prostate cells (RWPE-1), and endothelial control cells (HUVEC) using the MTS/PMS assay. For in vivo studies, BALB/C Nude mice were employed to gauge the therapeutic efficacy, biodistribution, and hematological implications post-treatment with BSA-coated AuNPs. Results: The BSA-coated AuNPs exhibited cytotoxic potential against PC-3 and LNCaP lines, while interactions with RWPE-1 and HUVEC remain subjects for further scrutiny. Within animal models, a diverse therapeutic response was observed, with certain instances indicating complete tumor regression. Biodistribution data emphasized the nanoparticles' affinity towards particular organs, and the majority of hematological indicators aligned with normative standards. Conclusions: BSA-coated AuNPs manifest substantial promise as therapeutic tools in treating prostate cancer. The present research not only accentuates the nanoparticles' efficacy but also stresses the imperative of optimization to ascertain both selectivity and safety. Such findings illuminate a promising trajectory for avant-garde therapeutic modalities, holding substantial implications for public health advancements.
Development of radioactive nanoparticles functionalized with gum arabic to be used in nanobrachytherapy
2023 - ROSERO, WILMMER A.A.; BARBEZAN, ANGELICA B.; RIGO, MARIA E.Z.; RODRIGUES, PRISCILA S.; TEODORO, LARA E.H.; TALACIMON, CRISTHIAN F.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.
The development of new materials emerges as an alternative to the treatment of cancer, from the combination of nanotechnology and brachytherapy a new area of research was born, Nanobrachytherapy, which through the properties of nanometric materials can achieve better results in the fight against cancer. The objective of this work is classified as radiotherapy, which consists of the use of ionizing radiation to destroy or inhibit the growth of abnormal cells that form a tumor. [1] The ability to integrate NPsAu into biological systems is due to the nanometric dimensions of NPsAu probes which facilitate their incorporation into biological systems, as well as their bioconjugation and non-cytotoxic potential. [2] Taking into account the previous objective, gold was selected as the base element for obtaining nanometric systems, which due to its chemical richness and especially due to the intrinsic properties of one of its radioisotopes, which would allow us in theory to meet the stated objective. . Initially, it was based on the knowledge of the literature, and non-radioactive nanometric systems were obtained, and after a series of stability, characterization and application tests, the radioactive nanometric systems were obtained. Working with radioactive systems posed a great challenge, and up to now it presents us with situations to solve, but we have managed to create a methodology for obtaining, characterizing and applying radioactive gold nanoparticles, and also obtaining positive results from their application.
Possible molds for a new brachytherapy source for spinal and intracranial cancer
2023 - TEODORO, LARA E.H.; TALACIMON, CRISTHIAN F.; RIGO, MARIA E.Z.; RODRIGUES, PRISCILA S.; NOGUEIRA, THUANY C.; ROSERO, WILMMER A.A.; VIEIRA, JOSE M.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.
Central Nervous System (CNS) cancer is the 18th most incident cancer in the world, according to the World Health Organization (WHO), and in 2020, in Brazil, it represented 2.5% of all new cancer deaths [1]. Brachytherapy is a type of radiotherapy that positions the radioactive source close to (or in contact with) the tumor. Thus, the targeted region receives most of the dose, protecting the healthy tissues adjacent to the tumor. A promising radioactive source for use in brachytherapy for the treatment of CNS cancer is phosphorus-32 in a polymeric substrate. This source has been prominent as a minimally invasive treatment for craniopharyngiomas and in the treatment of metastatic bone diseases in general [2]. To produce such a source, it is necessary to search for possible molds that can conform the polymeric material into the desired format. Several tests were carried out to determine the best mold for the radioactive source manufacture. Different materials were tested to observe if the mold material would react with the source's components, silicone rubber mixed with orthophosphoric acid. In order to be considered a possible mold, the mixture should cure; if the cure did not concretize, the mold would be descarted. It was concluded that polystyrene (PS) obtained the best result, due to the ease of unmold after the resin curing process.
Thermoluminescent dosimetry planning through MNCP
2023 - NOGUEIRA, THUANY; TALACIMON, CRISTHIAN; TEODORO, LARA; RIGO, MARIA; RODRIGUES, PRISCILA; ANGELOCCI, LUCAS; NOVAES, HAMONA; ZEITUNI, CARLOS; ROSTELATO, MARIA
Using a Monte Carlo simulation to analyze the ideal activity for a phosphorus-32 polymeric brachytherapy source for paraspinal tumors
2023 - TEODORO, LARA E.H.; BURIN, ANA L.; TALACIMON, CRISTHIAN F.; MEDEIROS, ILCA M.M.A.; RIGO, MARIA E.Z.; TAVARES, PAULO V. dos S.; RODRIGUES, PRISCILA S.; NOGUEIRA, THUANY C.; ROSERO, WILMMER A.A.; RODRIGUES JUNIOR, ORLANDO; VIEIRA, JOSE M.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.
Investigating a dopant for mitigating the natural degradation of Fricke Xylenol Gel dosimeters
2023 - TALACIMON, CRISTHIAN; ILCA, MEDEIROS; TEODORO, LARA; RIGO, MARIA; GESSERAME, MAYSA; TAVARES, PAULO; RODRIGUES, PRISCILA; NOGUEIRA, THUANY; ROSERO, WILMMER; RODRIGUES JUNIOR, ORLANDO; ZEITUNI, CARLOS; ROSTELATO, MARIA
How to select a dosimeter?
2023 - MEDEIROS, ILCA M.A.M.; SILVA, ANA C.K. de S.; TALACIMON, CRISTHIAN F.; MOURA, JOAO A.; TEODORO, LARA E.H.; RIGO, MARIA E.Z.; RODRIGUES, PRISCILA S.; ROSERO, WILMMER A.A.; ROSTELATO, MARIA E.C.M.; ZEITUNI, CARLOS A.
Feasibility study of fricke xylenol gel as a dosimeter for low dose rate brachytherapy sources
2023 - TALACIMON, CRISTHIAN; MEDEIROS, ILCA; TEODORO, LARA; RIGO, MARIA; GESSERAME, MAYSA; TAVARES, PAULO; RODRIGUES, PRISCILA; NOGUEIRA, THUANY; ROSERO, WILMMER; RODRIGUES JUNIOR, ORLANDO; ZEITUNI, CARLOS; ROSTELATO, MARIA ELISA CHUERY MA
Dosimetric approach of Au-198 nanoparticles with radiochromic film
2023 - RIGO, MARIA; ANGELOCCI, LUCAS; RODRIGUES, PRISCILA; TALACIMON, CRISTHIAN; MEDEIROS, ILCA; TEODORO, LARA; NOGUEIRA, THUANY; ROSERO, WILMMER; ZEITUNI, CARLOS; ROSTELATO, MARIA
Characterization of FXG dosimeters with gold nanoparticles for brachytherapy applications
2023 - RODRIGUES, PRISCILA; BURIN, ANA; BARBEZAN, ANGELICA; TALACIMON, CRISTHIAN; ILCA, MEDEIROS; TEODORO, LARA E.H.; RIGO, MARIA; GESSERAME, MAYSA; TAVARES, PAULO; NOGUEIRA, THUANY; ROSERO, WILMMER; RODRIGUES JUNIOR, ORLANDO; ZEITUNI, CARLOS; ROSTELATO, MARIA