HYLTON MATSUDA
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Artigo IPEN-doc 29832 A new 124Xe irradiation system for 123I production2023 - COSTA, OSVALDO L. da; BARCELLOS, HENRIQUE; MATSUDA, HYLTON; SUMIYA, LUIZ C. do A.; JUNQUEIRA, FERNANDO de C.; MATSUDA, MARGARETH M.N.; LAPOLLI, ANDRE L.Since 2001, Nuclear and Energy Research Institute IPEN-CNEN has produced weekly ultrapure iodine-123, using a manual irradiation system, fully developed in IPEN. Iodine-123 radiopharmaceuticals have been produced and distributed to hospitals and clinics of nuclear medicine, where several diagnostic imaging procedures for thyroid, brain and cardiovascular functions are performed. Due to the short half-life and emission of low-energy photons, this radioisotope becomes suitable for diagnosis in children. In the present work, the technical and constructive aspects of a new fully automated irradiation system, dedicated to 123I routine production, employing enriched xenon-124 gas as the target material is presented. This new system consists of a target, a water and helium cooling system, a cryogenic system, an electric power system, and a control and process monitoring unit, composed of supervisory software, connected to a programmable logic controller via personal computer. In this new concept, there is no need for human intervention during radioisotope production, reducing the possibility of eventual failures or incidents involving radioactive material. By using this new system, a specific yield of 2.70 mCi/μAh per irradiation was achieved in validation runs, and after three years of routine production of iodine- 123, the system showed reliability and resilience.Artigo IPEN-doc 29113 Design and assembly of an XY-type beam current monitor for cyclotron accelerators2023 - BARCELLOS, HENRIQUE; MATSUDA, HYLTON; LAPOLLI, ANDRE L.; SUMIYA, LUIZ C. do A.; JUNQUEIRA, FERNANDO de C.; COSTA, OSVALDO L. daA water-cooled XY-type beam current monitor was designed, manufactured and assembled in a cyclotron accelerator beam transport line. Tests were performed, demonstrating that apparatus is an instrument of great assistance in proton beam position. The XY-type beam current monitor has been widely used in liquid target irradiations, employing irradiation system which were originally designed for irradiations on 18 MeV cyclotron accelerator (Cyclone 18, IBA) only, however, with this apparatus, the target may be exchanged between the 30 MeV (Cyclone 30, IBA) and 18 MeV cyclotrons.Artigo IPEN-doc 24129 A new 124Xe irradiation system for 123I routine production at the 30 MeV IPEN-CNEN/SP cyclotron2017 - LAPOLLI, ANDRE L.; BARCELLOS, HENRIQUE; MATSUDA, HYLTON; SUMIYA, LUIZ C. do A.; JUNQUEIRA, FERNANDO de C.Since 2001 the Nuclear and Energy Research Institute (IPEN/CNEN-SP, Brazil) has produced about 2.5 mCi/mAh of 123I weekly using a manual irradiation system fully developed by its researchers. Ultrapure 123I has been produced and distributed to hospitals and clinics where several diagnostic imaging procedures are done for thyroid, brain and cardiovascular functions. Due to the short half-life and emission of low-energy photons, this radioisotope becomes suitable for diagnosis in children. Currently IPEN researchers are involved in the development of a new fully automated irradiation system dedicated to 123I routine production employing enriched xenon gas (124Xe) as the target material. This new system consists of a target port, a water and a helium cooling system, a cryogenic system, an electric power system, a control and process monitoring unit composed of a supervisory software connected to a Programmable Logic Controller (PLC) via personal computer. In this new concept, there is no need for human interference during radioisotope production, reducing the possibility of eventual failures or incidents involving radioactive material. In this way, with this new system, a specific yield of approximately 3.5 mCi/mAh per irradiation is expected and this will meet a large part of the national demand for this important radioisotope. In the present work will be presented all the technical and constructive aspects of this new system as well as the results obtained in the irradiation of tests.Artigo IPEN-doc 24094 A simple and powerful XY-type current monitor for 30 MeV IPEN/CNEN-SP cyclotron2017 - BARCELLOS, HENRIQUE; MATSUDA, HYLTON; SUMIYA, LUIZ C. do A.; JUNQUEIRA, FERNANDO de C.; COSTA, OSVALDO L. daA water-cooled XY-type current monitor was designed and built in the Cyclotrons Laboratory of the Nuclear and Energy Research Institute (IPEN). It is a very simple design and easily adaptable to the cyclotron beam lines. Tests were done demonstrating to be an instrument of great assistance in proton beam position along beam transport line and target port. Nowadays the XY-type current monitor has been widely used in 18F-FDG routine productions, employing irradiation system which were originally designed for productions on 18 MeV cyclotron accelerator only, however, applying the XY-type current monitor the target port may be exchanged between the 30 MeV and 18 MeV cyclotrons and the observed results are in perfect agreement with expected.Artigo IPEN-doc 21021 Otimização das condições de análise CIDG e, FDG por cromatografia liquida de alta eficiência (CLAE) acoplado a detector amperométrico pulsado (DAP)2015 - CASTRO, THAIS O.M. de; MENGATTI, JAIR; MATSUDA, HYLTON; ARAUJO, ELAINE B. de; FUKUMORI, NEUZA T.O.; MATSUDA, MARGARETH M.N.Artigo IPEN-doc 08823 Sistema para avaliacao, em tempo real, da homogeneidade do feixe externo do Ciclotron Cyclone 30 do IPEN-CNEN/SP2002 - MATSUDA, H.; SCIANI, V.Artigo IPEN-doc 13235 Production of sup(123)I-MIBG at IPEN-CNEN/SP2005 - BARBOZA, M.F. de; SCIANI, V.; HERRERIAS, R.; MATSUDA, M.M.N.; FUKUMORI, N.T.O.; SUMIYA, L.C.A.; MATSUDA, H.; SOUZA, A.A.; GOES, M.M.; PIRES, J.T.; MENGATTI, J.; SILVA, C.P.G.Artigo IPEN-doc 11185 Synthesis and quality control of sup(18)F-FDG at IPEN-CNEN/SP2005 - BARBOZA, M.F.; SCIANI, V.; HERRERIAS, R.; SUMIYA, L.C.; BRUZINGA, W.; GOES, M.M.; BAMBALAS, E.; MARIALVA NETO, A.A.; SOUZA, A.A.; PIRES, J.A.; MATSUDA, H.; MENGATTI, J.; SILVA, C.P.G.Artigo IPEN-doc 07222 Parametros relevantes na irradiacao de agua enriquecida em ciclotron, visando a otimizacao e a seguranca operacional na obtencao do ion sup(18)Fsup(-)2000 - SCIANI, V.; MATSUDA, H.; LAPOLLI, A.L.; SUMIYA, L.C.A.; COSTA, O.L.; LIMA, W.Dissertação IPEN-doc 07535 Monitoracao do feixe externo do ciclotron cyclone 30 do IPEN-CNEN/SP2002 - MATSUDA, HYLTON