HELENA OKADA SILVA
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Artigo IPEN-doc 22617 Suppression and stimulation of mineralocorticoid hormones (MCH) in the simple virilizing form of congenital adrenal hyperplasia (CAH) evaluated by the quantitation in adrenal venous blood1983 - WAJCHENBERG, B.L.; BIGLIERI, E.G.; OKADA, H.; MALERBI, D.A.C.; ACHANDO, S.S.; KATER, C.E.Four untreated female patients with the nonsalt-losing form of congenital virilizing adrenal hyperplasia (21-hydroxylase deficiency) (21-OHD) maintained on a daily sodium intake of 120 m-equiv were studied by bilateral adrenal vein catheterization. Simultaneous right and left adrenal and peripheral blood samples were collected for determination of cortisol (F), progesterone (P), 17-hydroxyprogesterone (17-OHP), aldosterone (Aldo), and deoxycorticosterone (DOC). All patients were studied during sequential ACTH suppression (30 min after intravenous administration of 4 mg of dexamethasone) and stimulation (5 min after intravenous administration of 250 μg β-ACTH [cosyntropin]). Basal peripheral concentrations of Aldo, DOC, P and 17-OHP were increased, whereas F concentrations were in the lower limit of the normal range. Dexamethasone suppressed adrenal secretion in all subjects. Subsequent adrenal stimulation by ACTH increased P, 17-OHP and DOC, whereas F returned to only control levels. DOC responses to ACTH in the adrenal vein effluents correlated significantly with Aldo responses but not with the 17-OHP increments, suggesting that the adrenal responses of Aldo and DOC to ACTH are events that probably occur in the same zone.Publicação IPEN-doc 02397 Preparacao de L-NHsub(2)-asparagina-sup(99)Tc1986 - SILVA, H.O.; SILVA, C.P.G.; SOSA de PEREIRA, N.P.Publicação IPEN-doc 00914 Dosagem de cortisol plasmatico por competicao a proteina fixadora (CBG)1977 - OKADA, H.; TOMBASCIA, M.A.; WAJCHENBERG, B.L.; PIERONI, R.R.Publicação IPEN-doc 00367 Hipertensao mineralocorticoide: aspectos clinicos e laboratoriais com enfase na venografia percutanea seletiva associada a dosagem de aldosterona na veia adrenal1977 - WAJCHENBERG, B.L.; LIBERMAN, B.; NOVAES, M.; TAMBASCIA, M.A.; LIMA, S.; SABAGGA, E.; OKADA, H.; PIERONI, R.R.; FARIA, C.V.; BLOISE, W.; MATTAR, E.Publicação IPEN-doc 04584 Advances in sup (99m)Tc labelling of antibodies1993 - OKADA, H.; MURAMOTO, E.; SOUZA, I.T.T.Publicação IPEN-doc 04308 Aspectos praticos da producao e aplicacao de anticorpos monoclonais como radiofarmacos1992 - OKADA, H.; SOUZA, I.T.T.; OSSO JUNIOR, J.A.Publicação IPEN-doc 03999 Monoclonal antibody as radiopharmaceutical1991 - SOUZA, I.T.T.; OKADA, H.; SILVA, C.P.G.Publicação IPEN-doc 03602 Anticorpos monoclonais radiomarcados: uma revisao1990 - SOUZA, I.T.T.; OKADA, H.Publicação IPEN-doc 03660 Preparacao de anti-miosina cardiaca humana: uma revisao1990 - OKADA, H.; SOUZA, I.T.T.Publicação IPEN-doc 03810 Radioiodacao de anticorpo monoclonal anti-CEA intacto1990 - OKADA, H.; SOUZA, I.T.T.; SILVA, C.P.G.