ANDREZA APARECIDA DEL CARMEN CASTRO GONZALEZ
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Artigo IPEN-doc 26242 Gold nanoparticles stabilized with gum arabic for cancer treatment2019 - ROSERO, WILMMER A.A.; NOGUEIRA, BEATRIZ R.; SOUZA, CARLA D. de; GONZALEZ, ANDREZA A.D.C.C.; BARBEZAN, ANGELICA B.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.Cancer is a group of diseases characterized by uncontrolled growth and abnormal spread of cells. The number of deaths due to cancer is higher than the ones caused by AIDS, tuberculosis and malaria combined. Among the different options of cancer treatment radiotherapy (teletherapy and brachytherapy) sta nds out. The presence of gold nanoparticles (AuNPs) may enhance energy deposition for teletherapy treatment. The use of nanoparticles for brachytherapy have been studied, and AuNPs is a good option once they can easily permeate tumor vasculature and remain in tumors. However, the tumor uptake of AuNPs may be significantly reduced due the attenuation with the formation of the protein coronas. The objective of this work is present the functionalization of AuNPs with arabic gum (GA). GA is a biocompatible, non toxic, water soluble, natural gum obtained from Acacia senegal tree. In this study, a synthesis of gold nanoparticles (AuNPs), based on Turkevich method, using citrate (NaCit) solution as reducing agent and a HAuCl4 solution, under vigorously stirring and boiling temperature, going from a light yellow to a wine red in three minutes. The functionalization of the nanoparticles was performed with Arabic gum solutions, in three different concentrations , which were a dded under stirring to the AuNPs already obtai ned. Samples were characterized to measure the size of the samples. Lower concentrations o GA in the solution presented smaller coated particles (up to 45 nm).Resumo IPEN-doc 25646 New gold-198 nanoparticle synthesis to be used in cancer treatment2018 - SOUZA, C.D. de; ROSTELATO, M.C.M.; ZEITUNI, C.; GONZALEZ, A. del C.C.; NOGUEIRA, B.R.Artigo IPEN-doc 24173 Coatings of nanoparticles applied to brachytherapy treatments2017 - GONZALEZ, ANDREZA A.D.C.C.; ROSTELATO, MARIA E.C.M.; SOUZA, CARLA D.; RODRIGUES, BRUNA T.; SOUZA, DAIANE C.B.; ZEITUNI, CARLOS A.; NOGUEIRA, BEATRIZ R.Resumo IPEN-doc 23127 Experiment to access Iodine-125 leakage in different vials2017 - SOUZA, C.D. de; ROSTELATO, M.C.M.; ZEITUNI, C.; COSTA, O. da; RODRIGUES, B.T.; GONZALEZ, A.C.; MARQUES, J. de O.Purpose: There are several challenges when developing a laboratory to produce radioactive sources. From choosing a prototype to radiation safety, the task is enormous. During the past 15 years, our research group is developing a laboratory to produce iodine-125 seed. These seeds are placed inside the cancer and release radiation directly in the target. The whole production line is full of new process and innovations. Among those, a new chemical reaction that deposit iodine-125 onto silver (core) was developed. This paper presents a comparison between vials in order to access their capability to retain radioactive iodine. Also, the fixation percentage in a silver core was taken into account. This information will be used to select a vial to be implemented at the iodine-125 sources manufacture laboratory. Methods: Vials made with polymers and glass was tested. Iodine-125 were placed in the vials overnight at rt. Seven vials with different materials (glass, dark glass, and plastics) were evaluated. Results: The selected vial (borosilicate glass 1 mL total volume) loss 17.61% of iodine in 24 hours and presented the highest iodine intake. It was noticeable that the vial material influenced both iodine intake and iodine loss. The goal is to maximize the reaction yield to result in a less costly product. Conclusion: We have selected the best vial for our reaction in regards to leakage and yield.