ANDREZA APARECIDA DEL CARMEN CASTRO GONZALEZ
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Resumo IPEN-doc 27516 Estudo de diferentes revestimentos em nanopartícula aplicada ao tratamento de câncer2020 - GONZALEZ, ANDREZA A.D.C.C.; ROSTELATO, MARIA E.C.M.Resumo IPEN-doc 26589 Estudo de diferentes revestimentos em nanopartícula aplicada ao tratamento de câncer2019 - GONZALEZ, ANDREZA A. del C.C.; ROSTELATO, MARIA E.C.M.Artigo IPEN-doc 26242 Gold nanoparticles stabilized with gum arabic for cancer treatment2019 - ROSERO, WILMMER A.A.; NOGUEIRA, BEATRIZ R.; SOUZA, CARLA D. de; GONZALEZ, ANDREZA A.D.C.C.; BARBEZAN, ANGELICA B.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.Cancer is a group of diseases characterized by uncontrolled growth and abnormal spread of cells. The number of deaths due to cancer is higher than the ones caused by AIDS, tuberculosis and malaria combined. Among the different options of cancer treatment radiotherapy (teletherapy and brachytherapy) sta nds out. The presence of gold nanoparticles (AuNPs) may enhance energy deposition for teletherapy treatment. The use of nanoparticles for brachytherapy have been studied, and AuNPs is a good option once they can easily permeate tumor vasculature and remain in tumors. However, the tumor uptake of AuNPs may be significantly reduced due the attenuation with the formation of the protein coronas. The objective of this work is present the functionalization of AuNPs with arabic gum (GA). GA is a biocompatible, non toxic, water soluble, natural gum obtained from Acacia senegal tree. In this study, a synthesis of gold nanoparticles (AuNPs), based on Turkevich method, using citrate (NaCit) solution as reducing agent and a HAuCl4 solution, under vigorously stirring and boiling temperature, going from a light yellow to a wine red in three minutes. The functionalization of the nanoparticles was performed with Arabic gum solutions, in three different concentrations , which were a dded under stirring to the AuNPs already obtai ned. Samples were characterized to measure the size of the samples. Lower concentrations o GA in the solution presented smaller coated particles (up to 45 nm).Resumo IPEN-doc 25646 New gold-198 nanoparticle synthesis to be used in cancer treatment2018 - SOUZA, C.D. de; ROSTELATO, M.C.M.; ZEITUNI, C.; GONZALEZ, A. del C.C.; NOGUEIRA, B.R.Resumo IPEN-doc 25159 Estudo de diferentes revestimentos em nanopartícula aplicada ao tratamento de câncer2018 - GONZALEZ, ANDREZA A. del C.C.; ROSTELATO, MARIA E.M.