MARA TANIA S. ALCANTARA
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Artigo IPEN-doc 26271 Synthesis of polymeric gels crosslinked by ionizing radiation for treatment of cutaneous leishmaniasis2019 - OLIVEIRA, MARIA J.A. de; MOREIRA, EDSON G.; SALVADOR, PABLO A.V.; ALCANTARA, MARA T.S.; LUGAO, ADEMAR B.Ionizing radiation is a very efficient, versatile and clean tool for modifying polymers for various applications, including in the biomedical area. The advantages of using radiation include the ability to process materials in any physical form, at a convenient temperature, often at room temperature. There is no need for the use of initiators or other chemicals and it is easily carried out with high reliability and does not generate any waste. In the research support area, several materials have been treated in order to find correlations between the applied dose and some property of the material susceptible to be modified with gamma radiation. This study proposes the development of polymeric gels (cream) with Glucantime (Sb V) and gel (cream) with silver nanoparticles, for alternative treatment of cutaneous Leishmaniasis. A cobalt-60 gamma irradiation source was used for crosslinking the polymers, forming the silver nanoparticles and simultaneous sterilization, leaving the product ready for use. Polymeric gels were characterized by physico-chemical techniques, instrumental nêutron activation analysis (INAA), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).Artigo IPEN-doc 26241 Effectiveness of the hydrogel dressing crosslinked and sterilized by gamma radiation2019 - GEMELLI, KARINE K.; SOUSA, GRAZIELLY M. de; GEMELLI, TIAGO F.; FERREIRA, OBEDE R.; OLIVEIRA, MARIA J.A. de; ALCANTARA, MARA T.S.; LUGAO, ADEMAR B.Chronic wounds of difficult cicatrization are more incidents with an increased in life expectancy. The hydrogel with silver nanoparticles developed at the Nuclear Energetic Research Institute, crosslinked and sterilized by Gamma radiation, is inexpensive and has a simple manufacturing process that seems to be an alternative to the treatment of injuries. This experimental study compared the healing process of second intention of skin wounds of 4cm² on the back of 69 Wistar rats, considering the effectiveness of hydrogel dressings with silver nanoparticles. The animals were distributed in three groups that received treatment with hydrogel dressing, hydrogel with 22ppm of silver nanoparticles and hydrogel with 44ppm of silver nanoparticles, and the dressings were performed every 48 hours. The project was approved by the Animal Experiments Committee. Hydrogel dressings are transparent and allow accurate visualization of the center of the lesion. The part of the dressing in contact with the wound kept the medium moist, promoting interaction with the fluid of the lesion, besides adsorbing the moisture produced. The dressing replacement didn’t cause discomfort or pain, since the animals were manually contained during the procedure, and the cover is easy to remove without causing trauma to the healing tissue. Wounds remained free of fibrin formation and necrosis, and serous exudation of lesions was scarce. At 21 days all the lesions were healed showing that dressings weren’t negative to the second intention healing process.Artigo IPEN-doc 26240 Toxicity study using rat (WISTAR) model of a hydrogel dressing with silver nanoparticles crosslinked and sterilized by gamma radiation2019 - SOUSA, GRAZIELLY M. de; GEMELLI, KARINE K.; MARTINS, OZENILDE A.R.; OLIVEIRA, MARIA J.A. de; ALCANTARA, MARA T.S.; LUGAO, ADEMAR B.; ROGERO, JOSE R.Silver nanoparticles (NPAg) have a bactericidal and bacteriostatic action in combination with hydrogels to recover the damaged tissue, promoting healing of the wound. The objective of this study was to evaluate the toxicity of the hydrogel dressing with NPAg from the analysis of possible toxic effects on renal and hepatic functions. It is an experimental study with 85 male Wistar rats, young adults. Nanoprate hydrogel and bidrogel dressings were used at concentrations of 22 and 44 ppm, both crosslinked and sterilized by irradiation with gamma rays at the 25 kGy dose at the center of radiation technology (CTR). The animals were distributed according to the treatment received after surgical induction of the wound on the animal's back. They were euthanized with 24 hours, 3, 7, 14, 21 and 30 days and after collecting the blood to determine the biochemical parameters. The project was approved by CEUA FAPAC ITPAC PORTO. Data were analyzed using the Past, Shapiro-Wilk and Kruskal-Wallis programs. For distribution and comparison data ANOVA and Tukey test with a significance level of 95%. No changes were observed in relation to biochemical parameters (TGP, TGO, urea and creatinine), and there were no statistically significant differences between the three groups of animals, independent of time. It was possible to observe that the animals treated with 44 ppm had always lower mean values than the other two groups in all analyzes. The study showed that the dressings of NPAg tested may not induce toxicity, being necessary to complement with other tests, such as histopathological study and atomic absorption spectroscopy.