LUCIANA KOVACS DOS SANTOS
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Artigo IPEN-doc 23532 Determination of Fe in blood using portable X-ray fluorescence spectrometry: an alternative for sports medicine2016 - ZAMBONI, C.B.; METAIRON, S.; KOVACS, L.; MACEDO, D.V.; RIZZUTTO, M.A.An alternate methodology based on a portable X-ray fluorescence spectrometry (PXRFS) for determination of Fe in blood was evaluated. The iron concentrations was determined in whole blood of 18 male amateur athletes (runners) using this portable XRF spectrometer and compared with a control group (54 male donors at the same age but not involved with physical activities) obtained by XRF and NAA techniques. The Fe concentration in the blood of runners is an important factor in sports medicine contributing to the performance of endurance athletes as well as for proposing new protocols of clinical evaluation.Artigo IPEN-doc 22422 Blood elements concentration in cyclists investigated by instrumental neutron activation analysis2016 - ZAMBONI, C.B.; KOVACS, L.; METAIRON, S.; AZEVEDO, M.R.A.; FURHOLZ, C.F.; UCHIDA, M.C.Resumo IPEN-doc 21541 Mineral status in cyclists2015 - KOVACS, LUCIANA; ZAMBONI, CIBELE; METAIRON, SABRINA; AZEVEDO, MARIA R.A.; FURHOLZ, CRISTINA; UCHIDA, MARCOResumo IPEN-doc 21413 Iron status in cyclists by NAA2015 - ZAMBONI, CIBELE B.; KOVACS, LUCIANA; MEDEIROS, ILCA M.M.A.; AZEVEDO, MARIA R.A. de; FURHOLZ, CRISTINA F.; UCHIDA, MARCOS C.Artigo IPEN-doc 21323 Development of sup(177)Lu-DOTA-dendrimer and determination of its effect on metal and ion levels in tumor tissue2015 - KOVACS, LUCIANA; TASSANO, MARCOS; CABRERA, MIREL; ZAMBONI, CIBELE B.; FERNANDEZ, MARCELO; ANJOS, ROBERTO M.; CABRAL, PABLODendrimers are synthetic nanomolecules with well-defined chemical structures. Different strategies have been used for radiolabeling dendrimers with different radioisotopes. In this study, the aim was to conjugate dendrimers with 177Lu, to observe the in vivo behavior of the labeled compound and to measure the elementary changes in tumor tissue that could be caused by ionizing radiation. PAMAM G4 dendrimers conjugated with DOTA were labeled with 177Lu. The radiolabeled compound was characterized and its stability was evaluated by reverse phase high performance liquid chromatography. Radiolabeling yield was >98% and stable for 24 hours. Biodistribution studies of 177Lu-DOTA-dendrimers in C57BL/6 melanoma-bearing mice showed blood clearance with hepatic and renal depuration and tumor uptake. The concentrations of Br, Ca, Cl, Fe, K, Mg, Na, Rb, S, and Zn were determined in tumor tissues of C57BL/6 mice treated with 177Lu-DOTA-dendrimers and in untreated mice. The results showed decreased concentrations of Br (62%), Ca (24%), Cl (51%), K (12%) and Na (60%) and increased concentrations of Fe (8%), Mg (28%), Rb (100%), S (6%) and Zn (4%) in tumor tissues of mice treated with 177Lu-DOTA-dendrimers. These data may be useful to evaluate changes in tumor tissues as indicators of damage that could be caused by ionizing radiation.Resumo IPEN-doc 20902 Labelling PAMAM dendrimers wit Tc-99m via HYNIC2014 - KOVACS, L.; TASSANO, M.; CABRERA, M.; FERNANDEZ, M.; ANJOS, R.; CABRAL, P.; PORCAL, W.Artigo IPEN-doc 20701 Na, K, Ca, Mg, and U-series in fossil bone and the proposal of a radial diffusion - adsorption model of uranium uptake2014 - CID, A.S.; ANJOS, R.M.; ZAMBONI, C.B.; CARDOSO, R.; MUNIZ, M.; CORONA, A.; VALLADARES, D.L.; KOVACS, L.; MACARIO, K.; PEREA, D.; GOSO, C.; VELASCO, H.Artigo IPEN-doc 20662 Investigation of Fe and Ca in non-stimulated human saliva using NAA2014 - MEDEIROS, J.A.G. de; ZAMBONI, C.B.; KOVACS, L.; LEWGOY, H.R.Artigo IPEN-doc 20619 Sulfur status in long distance runners2014 - KOVACS, L.; ZAMBONI, C.; LOURENCO, T.; MACEDO, D.Capítulo IPEN-doc 14715 NAA technique for clinical investigation of mice immunized with bothrop venom2009 - ZAMBONI, C.B.; AGUIAR, R.; KOVACS, L.; SUZUKI, M.; SANT'ANNA, O.A.