SABRINA METAIRON
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Capítulo IPEN-doc 28718 Aplicações na área da saúde e meio ambiente desenvolvidas no LEER2022 - ZAMBONI, CIBELE B.; METAIRON, SABRINA; GIOVANNI, DALTON N.S.; MEDEIROS, JOSE A.G. deO Laboratório de Espectroscopia e Espectrometria das Radiações (LEER) realiza pesquisas em Física Aplicada na área da saúde, nutrição, meio ambiente e correlatas utilizando técnicas nucleares e atômicas. As investigações são realizadas utilizando as técnicas de Espectroscopia e Espectrometria de raios gama, Ativação Neutrônica e Fluorescência de Raios-X. O LEER atua também na área de Ensino em Física, na implementação de métodos didáticos e na divulgação cientifica da física das radiações. Estas atividades envolvem estudantes de todos os níveis, de Iniciação Científica ao Doutorado, bem como Pós – doutorando e Cooperações de âmbito Nacional e Internacional com Instituições de referência (IF-USP, IBu, Unisa, UFF, Unifesp, HU-USP, Unicid, Unicamp, UNSL/San Luis-Argentina e Udelar/Montevideo-Uruguay). O programa de atividades estabelecido no LEER caracteriza-se pela interação entre as diferentes áreas da ciência que atuam no âmbito da saúde e meio ambiente, incluindo: Elaboração de propostas tecnológicas para a melhoria da qualidade vida de populações carentes e desprovidas de atendimento médico; Caracterização multielementar de novos medicamentos, vacinas e soros (antivenenos); Elaboração de propostas que possam suprimir/minimizar ou agregar melhorias no uso de modelos animais; Estudo das alterações ecológicas e os processos ambientalmente danosos relacionando-os ao ecossistema que incorporem as dimensões físicas, químicas e toxicológicas. Esses temas compõem monografias, dissertações e teses contribuindo para formação recursos.Artigo IPEN-doc 26908 Determination of inorganic elements in blood of mice immunized with Bothrops Snake venom using XRF and NAA2015 - SILVA, L.F.F.L. da; ZAMBONI, C.B.; BAHOVSCHI, V.; METAIRON, S.; SUZUKI, M.F.; SANTANNA, O.A.; RIZZUTTO, M.A.In this work, mice genetically modified [HIII line] were immunized against different Bothrops snake venoms to produce anti-Bothrops serum (antivenom). The Neutron Activation Analysis (NAA) and Energy Dispersive X-Ray Fluorescence (EDXRF) techniques were used to evaluate Ca and Fe concentrations in blood of these immunized mice in order to establish a potential correlation between both phenotypes: antibody response and blood constituents after Bothrops venom administration. The results were compared with the control group (mice not immunized) and with human being estimative. These data are important for clinical screening of patients submitted to immunological therapy as well as the understanding of the envenoming mechanisms.Artigo IPEN-doc 26266 Correlation analysis of inorganic elements in whole blood of GRMD dogs using INAA2019 - METAIRON, SABRINA; ZAMBONI, CIBELE B.; SILVA, DALTON G.N. daInstrumental neutron activation analysis technique (INAA) has been used to determine Br, Ca, Cl, Cr, Fe, K, Mg, Na, P and S concentrations in whole blood of GRMD dogs’ samples from control, carrier and affected dogs (treated and untreated). The GRMD dogs are relevant as an experimental model for Duchenne Muscular Dystrophy (DMD), which is the most severe and prevalent type of muscular dystrophy. Muscle weakness, premature death and instability of the membrane that involves the muscle fibers - causing functional/structural abnormalities and cell death - are main characteristics of this genetic disease. To show in more details the alterations that this disease may cause in whole blood, correlations matrixes were generated for control, carried and affected groups permitting a comparison between them. The results emphasize physiologic differences for K and Mg and suggest that Br results are altered, emphasizing a constant monitoring need. Other than that, these results may help the researchers to evaluate the efficiency of new treatments and to compare the advantages of different treatment approaches before performing tests in patients with muscular dystrophy.Artigo IPEN-doc 25194 Evaluation of ions and metals in the blood of GRMD dogs submitted to hASCs therapy by NAA and XRF techniques2019 - METAIRON, SABRINA; ZAMBONI, CIBELE B.; SUZUKI, MIRIAM F.; BUENO, CARLOS R.The elements Br, Ca, Cl, Cr, Fe, K, Mg, Na, P, Rb, S, and Zn were investigated in the whole blood samples of Golden Retriever dogs submitted to cell therapy (hASCs). These analyses were performed over 2 years using Neutron Activation Analysis and X-Ray Fluorescence techniques. The results were compared with control and untreated dog's. A significant increase was observed in K blood levels. There was also variation in blood levels of Br, Cr, Fe, Rb, S, and Zn.Artigo IPEN-doc 23532 Determination of Fe in blood using portable X-ray fluorescence spectrometry: an alternative for sports medicine2016 - ZAMBONI, C.B.; METAIRON, S.; KOVACS, L.; MACEDO, D.V.; RIZZUTTO, M.A.An alternate methodology based on a portable X-ray fluorescence spectrometry (PXRFS) for determination of Fe in blood was evaluated. The iron concentrations was determined in whole blood of 18 male amateur athletes (runners) using this portable XRF spectrometer and compared with a control group (54 male donors at the same age but not involved with physical activities) obtained by XRF and NAA techniques. The Fe concentration in the blood of runners is an important factor in sports medicine contributing to the performance of endurance athletes as well as for proposing new protocols of clinical evaluation.Artigo IPEN-doc 22408 Inorganic elements in blood of mice immunized with snake venom using NAA and XRF techniques2016 - METAIRON, S.; ZAMBONI, C.B.; SUZUKI, M.F.; SILVA, L.F.F.L. da; RIZZUTTO, M.A.Artigo IPEN-doc 21759 Comparative study of inorganic elements determined in whole blood from Dmdsup(mdx)/J mice strain by EDXRF and NAA analytical techniques2016 - REDIGOLO, M.M.; SATO, I.M.; METAIRON, S.; ZAMBONI, C.B.Resumo IPEN-doc 21552 Inorganic elements in blood of mice (HIII) immunized with snake venom using INAA and EDXRF techniques2015 - METAIRON, SABRINA; ZAMBONI, CIBELE; SUZUKI, MIRIAM; SILVA, LAIS L. da; RIZZUTTO, MARCIAArtigo IPEN-doc 21225 Determination of inorganic elements in blood of mice immunized with Bothrops snake venom using XRF and NAA2014 - LOPES da SILVA, L.F.F.; ZAMBONI, C.B.; BAHOVSCHI, V.; METAIRON, S.; SUZUKI, M.F.; SANT'ANNA, O.A.; RIZZUTTO, M.A.Resumo IPEN-doc 20753 Comparative study of inorganic elements determination in whole blood from Dmdsup(mdx)/J mice strain by EDXRF and NAA analytical techniques2014 - REDIGOLO, MARCELO M.; SATO, IVONE M.; METAIRON, SABRINA; ZAMBONI, CIBELE B.