Determination of inorganic elements in blood of mice immunized with Bothrops Snake venom using XRF and NAA
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2015
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Journal of Physics: Conference Series
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In this work, mice genetically modified [HIII line] were immunized against different
Bothrops snake venoms to produce anti-Bothrops serum (antivenom). The Neutron Activation
Analysis (NAA) and Energy Dispersive X-Ray Fluorescence (EDXRF) techniques were used
to evaluate Ca and Fe concentrations in blood of these immunized mice in order to establish a
potential correlation between both phenotypes: antibody response and blood constituents after
Bothrops venom administration. The results were compared with the control group (mice not
immunized) and with human being estimative. These data are important for clinical screening
of patients submitted to immunological therapy as well as the understanding of the envenoming
mechanisms.
Como referenciar
SILVA, L.F.F.L. da; ZAMBONI, C.B.; BAHOVSCHI, V.; METAIRON, S.; SUZUKI, M.F.; SANTANNA, O.A.; RIZZUTTO, M.A. Determination of inorganic elements in blood of mice immunized with Bothrops Snake venom using XRF and NAA. Journal of Physics: Conference Series, v. 630, p. 1-6, 2015. DOI: 10.1088/1742-6596/630/1/012005. Disponível em: http://repositorio.ipen.br/handle/123456789/31130. Acesso em: 11 May 2024.
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