CARLA DARUICH DE SOUZA

CARLA DARUICH DE SOUZA

(Fonte: Lattes)

Resumo

Bsc in Medical Physics from UNESP in Botucatu Compleated at IPEN, University of São Paulo: 1) Master's Degree: Comparison between methods for fixing iodine-125 on silver substrate for fabricating sources used in Brachytherapy / 2) PhD: Parameters for production of iodine-125 sources used in brachytherapy and "sandwich" doctorate: Washington State University - training in radiochemistry and organic chemistry / 3) Post doctorate: Production of nanosources for the treatment of cancer / 4) Project: Analysis of methods to obtain / produce nuclear material for use in a radioisotope thermoelectric generator (RTG)/ Advisor of the Professional Master's Degree in Radiation Technology in Health / Professor of the Professional Master Program in the disciplines Dosimetry for Radiotherapy and Radiotherapy Fundamentals / Professor of the Academic Master Program in the discipline TNA5805 - Brachytherapy: Fundamentals, Production, Application, Dosimetry and Quality Research Associate of KAERI - Korean Atomic Energy and Research Institute (Text obtained from the Currículo Lattes on October 6th 2021)

Formada em Física Médica pela UNESP em Botucatu Realizado no IPEN-USP/ SP: 1) Mestrado: Comparação entre métodos de fixação do iodo-125 em substrato de prata para confecção de fontes utilizadas em Braquiterapia / 2) Doutorado: Parâmetros para produção de confecção de fontes de iodo-125 utilizadas em Braquiterapia e Doutorado sanduíche: Washington State University - treinamento em radioquímica / 3) Pós doutorado: Produção de nanofontes para tratamento de câncer / 4) Projeto: Análise de formas de obtenção/produção do material nuclear para utilização em um gerador termoelétrico radioisotópico (RTG)/ Orientadora do Mestrado Profissional de Tecnologia das Radiações na Saúde/ Professora do Mestrado Profissional nas disciplinas Dosimetria para Radioterapia e Fundamentos de Radioterapia/ Professora do Mestrado Acadêmico na disciplina TNA5805 - Braquiterapia: Fundamentos, Produção, Aplicação, Dosimetria e Qualidade Research Associate do KAERI - Korean Atomic Energy and Research Institute (Texto extraído do Currículo Lattes em 06 out. 2021)

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RDC 330 in practice
2022 - GUERRA, D.; MARTINS, T.T.M.; RODRIGUES JUNIOR, O.; SOUZA, C.D. de
Medical radiology has social and academic relevance because it is a specialty that uses different types of radiation for diagnostic and therapeutic purposes. It requires a multidisciplinary team that is attentive to the changing guidelines imposed by the government. The rules are presented and enforced by the National Health Surveillance Agency (ANVISA) and the State and Municipal Health Surveillance (VISA). Currently, the ANVISA standard that regulates radiodiagnostic clinics is Collegiate Board Resolution 330 (RDC) and Normative Instructions (INs) 90, 91, 92, 93, 94, 95, 96 and 97, which dictate the rules of operation of the clinic in general and each equipment in particular. In this work, we evaluated the implementation of this new resolution, through a qualitative study, with the following procedures: interviews, analysis, comparison of results, and direct observation in 05 magnetic resonance centers of the private hospital network of the metropolitan region of Fortaleza. A question that the work intends to try to answer: Given the data collected, what will be the possible initial, medium and long-term impacts of the implementation of these Ins.
RDC 330 in practice
2021 - GUERRA, D.; MARTINS, T.T.M.; RODRIGUES JR, O.; SOUZA, C.D. de
Gold nanoparticle applied to brachytherapy
2019 - GONZALEZ, ANDREZA A.D.C.C.; SOUZA, CARLA D.; ARCOS, WILMER A.; RODRIGUES, BRUNA T.; DOMINGUES, PAULO R.; SPINOSA, TATYANA B.; ROSTELATO, MARIA E.C.M.
Cancer is a global public health problem, that consists in a disease is characterized by the uncontrolled growth of anomalous cells that impair the functioning of the body. One of the treatments for cancer is the brachytherapy. This technique a non-invasive treatment in which the radiation is placed close or in contact with the region to be treated, brachytherapy may save the healthy tissues and consequently reduces the amount of side effects. An unexplored strand is nanobrachytherapy, that unites the advantages of brachytherapy with the small size in the nanoparticle (NP), resulting in an even less invasive treatment. Nanotechnology is the science that studies the properties of nanometric materials with the aim of creating new materials with different properties of interest. In view of the synthesis of the NP and their applicabilities, there is a fundamental role that is made to coatings, which have the function of avoiding the aggregation of particles, stabilize and also control their functional properties. Besides being able to add molecules of interest, such as antibiotics and anti-inflammatories. Among the range of coatings, the most outstanding are polyethylene glycol (PEG). PEG improves the surface properties of NP and presents high stability under biomedical conditions. The NP have their size controlled, which facilitates their penetration into the vasculature, in addition to being a non-toxic coating. After the synthesis of gold nanoparticles (Au-NP) was developed, PEG were successfully incorporated into the surface. Incorporation was confirmed by DLS, FT-IR and HRTEM.
New gold-198 nanoparticle synthesis to be used in cancer treatment
2019 - SOUZA, CARLA D. de; ZEITUNI, CARLOS A.; ROSERO, WILMMER A.A.; NOGUEIRA, BEATRIZ R.; ROSTELATO, MARIA E.C.M.
Gold nanoparticles (NPs) have been intriguing scientists for over 100 years. Recently, they have been studied for new applications such as cancer treatment. Although the synthesis of gold nanoparticles is extensively reported, in the majority of cases the methodology is confused and/or not clear. We describe a new synthesis methodology for radioactive gold‐198 NPs. Gold-198 was activated in IPEN IEA-01 nuclear reactor to a neutron flux with 1013 order. After that, chloroauric acid (HAuCl4) was formed by dissolving the radioactive gold with aqua regia and performing repeated heating cycles. 0.1 mM HAuCl4 containing 100 μL of 1 M NaOH was prepared in a flask equipped with a reflux condenser. The solution was brought to boil and stirred with a PTFE‐coated magnetic stir‐bar. Then 5 mL of sodium citrate was rapidly added. The reaction turns from light yellow to clear, black, dark purple until the solution attained a wine‐red color (2–3 min). Dynamic light scattering (DLS) confirmed 8 nm particles. The presence of gold‐198 (197.968 g/mol; half‐life: 2.69517; decay mode: β‐; average energy: 1.3723 MeV) was confirmed by an ORTEC HPGe detector. DLS was performed after complete decay confirming the 8 nm diameter maintenance. We were able to achieve radioactive gold‐198 NPs and are performing further studies such as: coating reactions, in‐vitro and in‐vivo studies.
Gold nanoparticles stabilized with gum arabic for cancer treatment
2019 - ROSERO, WILMMER A.A.; NOGUEIRA, BEATRIZ R.; SOUZA, CARLA D. de; GONZALEZ, ANDREZA A.D.C.C.; BARBEZAN, ANGELICA B.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.
Cancer is a group of diseases characterized by uncontrolled growth and abnormal spread of cells. The number of deaths due to cancer is higher than the ones caused by AIDS, tuberculosis and malaria combined. Among the different options of cancer treatment radiotherapy (teletherapy and brachytherapy) sta nds out. The presence of gold nanoparticles (AuNPs) may enhance energy deposition for teletherapy treatment. The use of nanoparticles for brachytherapy have been studied, and AuNPs is a good option once they can easily permeate tumor vasculature and remain in tumors. However, the tumor uptake of AuNPs may be significantly reduced due the attenuation with the formation of the protein coronas. The objective of this work is present the functionalization of AuNPs with arabic gum (GA). GA is a biocompatible, non toxic, water soluble, natural gum obtained from Acacia senegal tree. In this study, a synthesis of gold nanoparticles (AuNPs), based on Turkevich method, using citrate (NaCit) solution as reducing agent and a HAuCl4 solution, under vigorously stirring and boiling temperature, going from a light yellow to a wine red in three minutes. The functionalization of the nanoparticles was performed with Arabic gum solutions, in three different concentrations , which were a dded under stirring to the AuNPs already obtai ned. Samples were characterized to measure the size of the samples. Lower concentrations o GA in the solution presented smaller coated particles (up to 45 nm).
Gamma spectrometry of iodine-125 produced in IEA-R1 nuclear reator, using HPGe detector and fixation into epoxy matrix disc
2019 - COSTA, OSVALDO L. da; SOUZA, DAIANE C.B. de; CASTANHO, FABIO G.; FEHER, ANSELMO; MOURA, JOÃO A.; SOUZA, CARLA D. de; OLIVEIRA, HENRIQUE B. de; MADUAR, MARCELO F.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.
Few places in the world produce iodine-125. In Brazil, the first production happened in nuclear reactor IEA-R1 located at Nuclear and Energy Research Institute – IPEN. To verify the quality of iodine-125 produced, because contaminants as iodine-126, caesium-134 and caesium-137 among others, may be produced in irradiation process, iodine-125 samples were immobilized into epoxy matrix disc, with the same geometry of a barium-133 reference radioactive source, used to calibrate an HPGe detector. The HPGe detector has a thin carbon composite window, which allows measure the iodine-125 photopeaks, between 27.1 and 35.4 keV.
Análise da região soldada por processo laser em microtubos de titânio por meio de ensaio metalográfico e microdureza
2018 - FEHER, A.; ROSTELATO, M.E.C.M.; ZEITUNI, C.A.; MOURA, J.A.; COSTA, O.L.; SOUZA, C.D.
Um dos materiais utilizados como invólucro de fontes radioativas seladas para aplicações na área da saúde é o titânio. Na construção de fontes radioativas seladas, o radioisótopo é confinado em uma cápsula de metal garantindo que não ocorra sua dispersão no meio externo. O processo de construção desse tipo de fonte requer muitas vezes a soldagem da cápsula, causando alterações das estruturas cristalinas do metal. Essas alterações podem resultar na fragilização da região de solda, ocasionando trincas e consequentemente a inutilização do conjunto. Este trabalho avaliou a possível existência de defeitos de soldagem por meio de ensaio metalográfico e de dureza. Foram realizados ensaios por microscopia óptica e MEV para avaliar a existência de trincas, poros, inclusões, falta de penetração e mordeduras. Foram realizados também ensaios de microdureza Vickers com a finalidade de verificar a variação da dureza entre o metal de base, zona termicamente afetada e zona fundida.
Coatings of nanoparticles applied to brachytherapy treatments
2017 - GONZALEZ, ANDREZA A.D.C.C.; ROSTELATO, MARIA E.C.M.; SOUZA, CARLA D.; RODRIGUES, BRUNA T.; SOUZA, DAIANE C.B.; ZEITUNI, CARLOS A.; NOGUEIRA, BEATRIZ R.
Brazilian demand for iodine-125 seeds in cancer treatment after a decade of medical procedures
2017 - COSTA, OSVALDO L. da; SOUZA, DAIANE C.B. de; FEHER, ANSELMO; MOURA, JOAO A.; SOUZA, CARLA D.; OLIVEIRA, HENRIQUE B. de; PELEIAS JUNIOR, FERNANDO S.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.
Study and methodologies for fixing epoxy resin in radioactive sources used for brachytherapy
2017 - RODRIGUES, BRUNA T.; ROSTELATO, MARIA E.C.M.; SOUZA, CARLA D.; TOZETTI, CINTIA A.; ZEITUNI, CARLOS A.; NOGUEIRA, BEATRIZ R.; SILVA, JOSE T.; K. JUNIOR, DIB; FERNANDES, VAGNER; SOUZA, RAQUEL V.; ABREU, RODRIGO T.
The World Health Organization (WHO) estimates that the number of new cancer cases worldwide will reach 15 million by 2020. The disease is already the second leading cause of death worldwide, being behind only cardiovascular disease. It is unquestionable that it is a public health problem, especially among developing countries. Prostate cancer is the most common among men, approximately 28.6%. The choice of type of treatment for prostate cancer should consider several factors such as: tumor size and extent, apparent aggressiveness (pathological characteristics), age, health. Among the methods applied, brachytherapy has been used in the initial and intermediate stages of the disease. Brachytherapy is a safe and effective treatment for localized prostate cancer. Brachytherapy is a form of radiotherapy in which radioactive seeds are placed in contact with or within the organ being treated. This technique allows a large dose of radiation to be released only on the target tumor that protects healthy surrounding tissues. Sources may have different shapes and sizes, but the one used for prostate cancer is usually 4.5 mm in length and 0.8 mm in diameter. About 80 to 120 seeds can be used per patient. Iodine-125 is the radioisotope most used in brachytherapy of the prostate, it emits 35,49keV X-rays in 100% of the decays, with average energy of 29 keV. The treatment of prostate cancer with permanent implantation of iodine-125 seeds has grown dramatically in the world in recent years. Most patients can return to normal life within three days with little or no pain.