VIVIANE PEREIRA GOULART
15 resultados
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Resumo IPEN-doc 22906 FTIR for the study of the biochemical changes promoted by PDT mediated by 5-ALA and its methyl-ester in neoplastic skin lesions2016 - ZEZELL, D.M.; LIMA, C.A.; GOULART, V.P.Artigo IPEN-doc 22900 Chemometric methods applied to FTIR spectra to discriminate treated and non-treated cutaneous malignant lesions from healthy skin2016 - LIMA, CASSIO A.; GOULART, VIVIANE; ZEZELL, DENISEChemometric methods were used to differentiate FTIR spectra of treated and nontreated malignant lesions from healthy skin. We conclude that the method can be used to evaluate the biological changes promoted by photodynamic treatment.Artigo IPEN-doc 22306 Evaluation of squamous cell skin carcinoma using ATR-FTIR spectroscopy associated to cluster analysis2014 - LIMA, C.A.; GOULART, V.; ZEZELL, D.M.Cluster Analysis were used as an unsupervised classification technique to differentiate FTIR spectra of normal and tumor skin. The results shown satisfactory separation in samples analyzed, highlighting the potential of the technique for diagnostic purposes.Artigo IPEN-doc 20857 Biochemical changes in cutaneous squamous cell carcinoma submitted to PDT using ATR-FTIR spectroscopy2015 - LIMA, CASSIO A.; GOULART, VIVIANE P.; CASTRO, PEDRO A.A. de; CORREA, LUCIANA; BENETTI, CAROLINA; ZEZELL, DENISE M.Nonmelanoma skin cancers are the most common form of malignancy in humans. Between the traditional treatment ways, the photodynamic therapy (PDT) is a promising alternative which is minimally invasive and do not requires surgical intervention or exposure to ionizing radiation. The understanding of the cascade of effects playing role in PDT is not fully understood, so that define and understand the biochemical events caused by photodynamic effect will hopefully result in designing better PDT protocols. In this study we investigated the potential of the FTIR spectroscopy to assess the biochemical changes caused by photodynamic therapy after 10 and 20 days of treatment using 5-aminolevulinic acid (ALA) as precursor of the photosensitizer photoporphyrin IX (PpIX). The amplitude values of second derivative from vibrational modes obtained with FTIR spectroscopy showed similar behavior with the morphological features observed in histopathological analysis, which showed active lesions even 20 days after PDT. Thus, the technique has the potential to be used to complement the investigation of the main biochemical changes that photodynamic therapy promotes in tissue.Artigo IPEN-doc 20832 ATR-FTIR spectroscopy for the assessment of biochemical changes in skin due to cutaneous squamous cell carcinoma2015 - LIMA, CASSIO A.; GOULART, VIVIANE P.; CORREA, LUCIANA; PEREIRA, THIAGO M.; ZEZELL, DENISE M.Nonmelanoma skin cancers represent 95% of cutaneous neoplasms. Among them, squamous cell carcinoma (SCC) is the more aggressive form and shows a pattern of possible metastatic profile. In this work, we used Fourier transform infrared spectroscopy (FTIR) spectroscopy to assess the biochemical changes in normal skin caused by squamous cell carcinoma induced by multi-stage chemical carcinogenesis in mice. Changes in the absorption intensities and shifts were observed in the vibrational modes associated to proteins, indicating changes in secondary conformation in the neoplastic tissue. Hierarchical cluster analysis was performed to evaluate the potential of the technique to differentiate the spectra of neoplastic and normal skin tissue, so that the accuracy obtained for this classification was 86.4%. In this sense, attenuated total reflection (ATR)-FTIR spectroscopy provides a useful tool to complement histopathological analysis in the clinical routine for the diagnosis of cutaneous squamous cell carcinoma.Resumo IPEN-doc 20643 Non-invasive monitoring of PDT on skin squamous cell carcinoma using the optical attenuation coefficient measured by OCT2014 - GOULART, VIVIANE P.; SANTOS, MOISES O. dos; CORREA, LUCIANA; LATRIVE, ANNE; LIMA, CASSIO A. de; ZEZELL, DENISE M.Resumo IPEN-doc 14703 Effects of Nd:YAG laser and professional fluoride application on chemical changes of enamel and its influence on caries prevention2009 - ANA, P.A.; GOULART, V.P.; ALBERTO, F.G.; TABCHOURY, C.P.M.; CURY, J.A.; ZEZELL, D.M.Resumo IPEN-doc 14585 Preventive effects on enamed by Nd:YAG laser and fluoride application2009 - ANA, P.A.; TABCHOURY, C.P.M.; GOULART, V.P.; ALBERO, F.G.; CURY, J.A.; ZEZELL, D.M.Resumo IPEN-doc 16035 FTIR spectroscopy monitoring chemical changes in enamel dentin and bone due to laser irradiation2010 - ZEZELL, DENISE M.; ANA, PATRICIA A.; BENETTI, CAROLINA; QUINTO JUNIOR, JOSE; PEREIRA, THIAGO M.; GOULART, VIVIANEResumo IPEN-doc 19167 Femtosecond laser high intensity irradiation as a proposal for adjunvant treatment in burned skin - an in vivo model2013 - SANTOS, MOISES O.; ROSSI, WAGNER; GOULART, VIVIANE P.; FREITAS, ANDERSON Z.; SAMAD, RICARDO E.; VIEIRA JUNIOR, NILSON D.; ZORN, TELMA M.T.; ZEZELL, DENISE M.