ATR-FTIR spectroscopy for the assessment of biochemical changes in skin due to cutaneous squamous cell carcinoma
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2015
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International Journal of Molecular Sciences
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Resumo
Nonmelanoma skin cancers represent 95% of cutaneous neoplasms. Among
them, squamous cell carcinoma (SCC) is the more aggressive form and shows a pattern of
possible metastatic profile. In this work, we used Fourier transform infrared spectroscopy
(FTIR) spectroscopy to assess the biochemical changes in normal skin caused by squamous
cell carcinoma induced by multi-stage chemical carcinogenesis in mice. Changes in the
absorption intensities and shifts were observed in the vibrational modes associated to
proteins, indicating changes in secondary conformation in the neoplastic tissue.
Hierarchical cluster analysis was performed to evaluate the potential of the technique to
differentiate the spectra of neoplastic and normal skin tissue, so that the accuracy obtained
for this classification was 86.4%. In this sense, attenuated total reflection (ATR)-FTIR
spectroscopy provides a useful tool to complement histopathological analysis in the
clinical routine for the diagnosis of cutaneous squamous cell carcinoma.
Como referenciar
LIMA, CASSIO A.; GOULART, VIVIANE P.; CORREA, LUCIANA; PEREIRA, THIAGO M.; ZEZELL, DENISE M. ATR-FTIR spectroscopy for the assessment of biochemical changes in skin due to cutaneous squamous cell carcinoma. International Journal of Molecular Sciences, v. 16, n. 4, p. 6621-6630, 2015. DOI: 10.3390/ijms16046621. Disponível em: http://repositorio.ipen.br/handle/123456789/23797. Acesso em: 09 May 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.