Biokinetics and radiation dosimetry for [4-(14)C]-cholesterol in humans
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2011
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INTERNATIONAL CONFERENCE ON DEVELOPMENT AND APPLICATIONS OF NUCLEAR TECHNOLOGIES
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Resumo
Medical and clinical researches utilize radiolabelled cholesterol to obtain information about
the physiology of cholesterol and of its several substrates (biliary acids, hormones and
vitamins) in the body. The radiotracers constitute a simple and accurate tool for metabolic
studies; however, the scientific community has shown certain reservations concerning the use
of radioisotopes. Probably, the apprehension is result of the question about the deleterious
radiation effects. Although the studies that utilize radioisotopes are approved by strict ethic
committees, most of them do not mention the radiometric doses at which the human subjects
are exposed during these studies. The International Commission on Radiological Protection
(ICRP) provides a generic carbon model (GCM) to calculate the effective dose of compounds
labeled with 14C, first described on ICRP publication 30. The effective dose coefficients for
most compounds appear to be greatly overestimated by the GCM in comparison with those
generated by more realistic models [1]. The GCM cannot be applied to the interpretation of
bioassay data with any degree of confidence [1]. The purpose of the present study is to
improve the generic biokinetic model [2] for use in the assessment of the internal dose
received by human subjects who were administered labelled cholesterol either orally or
intravenously. This model was used with the ANACOMP software to estimate the radiometric
doses with the MIRD techniques. To validate the model, the simulated profile curves were
compared with the profile curves described on the literature (Kruskal-Wallis test, P=0.4232).
The model reproduced the intestinal absorption of cholesterol and the excretion of cholesterol
in feces and urine. The estimated effective dose coefficient calculated for the reference man
described on ICRP publication 23 was 1.35x10-11 SvBq-1. The organs that received the highest
equivalent dose were the lower large intestine (1.03x10-10 GyBq-1), upper large intestine
(3.74x10-11 GyBq-1) and small intestine (1.58x10-11GyBq-1). The effective dose coefficient
calculated by the proposed dosimetric model was approximately forty-three times lower than
that which is calculated by the ICRP generic model (5.8x10-10 SvBq-1) for ingested 14C that
assumes complete absorption to blood.
Como referenciar
MARCATO, L.A.; HAMADA, M.M.; MESQUITA, C.H. Biokinetics and radiation dosimetry for [4-(14)C]-cholesterol in humans. In: DUDALA, JOANNA (ed.); STEGOWSKI, ZDZISLAW (ed.). In: INTERNATIONAL CONFERENCE ON DEVELOPMENT AND APPLICATIONS OF NUCLEAR TECHNOLOGIES, September 11-14, 2011, Krakow, Poland. Abstract... Krakow, Poland: Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, 2011. p. 164-164. Disponível em: http://repositorio.ipen.br/handle/123456789/33336. Acesso em: 12 May 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.