Biokinetics and radiation dosimetry for [4-(14)C]-cholesterol in humans

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dc.contributor.authorMARCATO, L.A.pt_BR
dc.contributor.authorHAMADA, M.M.pt_BR
dc.contributor.authorMESQUITA, C.H.pt_BR
dc.contributor.editorDUDALA, JOANNApt_BR
dc.contributor.editorSTEGOWSKI, ZDZISLAWpt_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoINTERNATIONAL CONFERENCE ON DEVELOPMENT AND APPLICATIONS OF NUCLEAR TECHNOLOGIESpt_BR
dc.date.accessioned2022-10-25T13:03:26Z
dc.date.available2022-10-25T13:03:26Z
dc.date.eventoSeptember 11-14, 2011pt_BR
dc.description.abstractMedical and clinical researches utilize radiolabelled cholesterol to obtain information about the physiology of cholesterol and of its several substrates (biliary acids, hormones and vitamins) in the body. The radiotracers constitute a simple and accurate tool for metabolic studies; however, the scientific community has shown certain reservations concerning the use of radioisotopes. Probably, the apprehension is result of the question about the deleterious radiation effects. Although the studies that utilize radioisotopes are approved by strict ethic committees, most of them do not mention the radiometric doses at which the human subjects are exposed during these studies. The International Commission on Radiological Protection (ICRP) provides a generic carbon model (GCM) to calculate the effective dose of compounds labeled with 14C, first described on ICRP publication 30. The effective dose coefficients for most compounds appear to be greatly overestimated by the GCM in comparison with those generated by more realistic models [1]. The GCM cannot be applied to the interpretation of bioassay data with any degree of confidence [1]. The purpose of the present study is to improve the generic biokinetic model [2] for use in the assessment of the internal dose received by human subjects who were administered labelled cholesterol either orally or intravenously. This model was used with the ANACOMP software to estimate the radiometric doses with the MIRD techniques. To validate the model, the simulated profile curves were compared with the profile curves described on the literature (Kruskal-Wallis test, P=0.4232). The model reproduced the intestinal absorption of cholesterol and the excretion of cholesterol in feces and urine. The estimated effective dose coefficient calculated for the reference man described on ICRP publication 23 was 1.35x10-11 SvBq-1. The organs that received the highest equivalent dose were the lower large intestine (1.03x10-10 GyBq-1), upper large intestine (3.74x10-11 GyBq-1) and small intestine (1.58x10-11GyBq-1). The effective dose coefficient calculated by the proposed dosimetric model was approximately forty-three times lower than that which is calculated by the ICRP generic model (5.8x10-10 SvBq-1) for ingested 14C that assumes complete absorption to blood.pt_BR
dc.event.siglaNUTECHpt_BR
dc.format.extent164-164pt_BR
dc.identifier.citationMARCATO, L.A.; HAMADA, M.M.; MESQUITA, C.H. Biokinetics and radiation dosimetry for [4-(14)C]-cholesterol in humans. In: DUDALA, JOANNA (ed.); STEGOWSKI, ZDZISLAW (ed.). In: INTERNATIONAL CONFERENCE ON DEVELOPMENT AND APPLICATIONS OF NUCLEAR TECHNOLOGIES, September 11-14, 2011, Krakow, Poland. <b>Abstract...</b> Krakow, Poland: Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, 2011. p. 164-164. Disponível em: http://repositorio.ipen.br/handle/123456789/33336.
dc.identifier.orcid0000-0002-6879-2468pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/33336
dc.localKrakow, Polandpt_BR
dc.local.eventoKrakow, Polandpt_BR
dc.publisherFaculty of Physics and Applied Computer Science, AGH University of Science and Technologypt_BR
dc.rightsopenAccesspt_BR
dc.subjectcholesterol
dc.subjectcarbon 14
dc.subjectdosimetry
dc.subjectbiochemical reaction kinetics
dc.subjectlabelled compounds
dc.subjectradiation doses
dc.titleBiokinetics and radiation dosimetry for [4-(14)C]-cholesterol in humanspt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorLARISSA ANDRETO MARCATO
ipen.autorCARLOS HENRIQUE DE MESQUITA
ipen.autorMARGARIDA MIZUE HAMADA
ipen.codigoautor9040
ipen.codigoautor1149
ipen.codigoautor1476
ipen.contributor.ipenauthorLARISSA ANDRETO MARCATO
ipen.contributor.ipenauthorCARLOS HENRIQUE DE MESQUITA
ipen.contributor.ipenauthorMARGARIDA MIZUE HAMADA
ipen.date.recebimento22-10
ipen.event.datapadronizada2011pt_BR
ipen.identifier.ipendoc26498pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
relation.isAuthorOfPublication85606b1b-8368-499d-9bcb-a2419fb98018
relation.isAuthorOfPublication20d22e5e-a0d1-4286-b4d9-20e5ac53cb51
relation.isAuthorOfPublication74139eee-5dbd-4dfd-b672-89cb56c5cce5
relation.isAuthorOfPublication.latestForDiscovery85606b1b-8368-499d-9bcb-a2419fb98018
sigepi.autor.atividadeMESQUITA, C.H.:1149:240:Npt_BR
sigepi.autor.atividadeHAMADA, M.M.:1476:240:Npt_BR
sigepi.autor.atividadeMARCATO, L.A.:9040:-1:Spt_BR
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