Acute toxicity assessment of fluoxetine hydrochloride (Prozac®) when submitted to electron beam irradiation

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dc.contributor.authorSANTOS, D.R.A.pt_BR
dc.contributor.authorGARCIA, V.S.G.pt_BR
dc.contributor.authorVILARRUBIA, A.C.S.pt_BR
dc.contributor.authorBORRELY, S.I.pt_BR
dc.contributor.editorDUDALA, JOANNApt_BR
dc.contributor.editorSTEGOWSKI, ZDZISLAWpt_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoINTERNATIONAL CONFERENCE ON DEVELOPMENT AND APPLICATIONS OF NUCLEAR TECHNOLOGIESpt_BR
dc.date.accessioned2022-10-25T12:58:12Z
dc.date.available2022-10-25T12:58:12Z
dc.date.eventoSeptember 11-14, 2011pt_BR
dc.description.abstractThe large-scale production of medicinal products is directly related to the presence of pharmaceutical drugs in sewage and water. The continuous input of medicines and its residues into the environment especially by sewage and wastewater generates an increasing need of new methods for its treatment and suitable control. The fluoxetine hydrochloride (FH), also known as Prozac®, is an active ingredient used in the treatment of depressive and anxiety disorders [1]. The present study focused on applying the ionizing radiation in order to reduce the acute toxicity of the FH drug solution, under its manipulated formula, to aquatic organisms. Hyalella azteca and Daphnia similis were the organisms used in the biological assays applied for the toxicity studies. It was used a Dynamitron electron beam accelerator and its energy was fixed at 1,4MeV for 5kGy and 10kGy doses [2]. For the calculation of the effective concentration (EC50) it was used the statistic program Trimmed Spearman - Karber. The average values for acute toxicity of FH were 0.59mg.L-1 (EC5 096h) for Hyalella azteca and of 1,44mg.L-1 (EC5 048h) for Daphnia similis. After irradiation of the FH aqueous solution, the following EC50 average values were obtained: 7.81mg.L-1 (5kGy) and 7.97mg.L-1 (10kGy) for Hyalella azteca; 8,46mg.L-1 (5kGy ) and 7.31mg.L-1 (10kGy ) for Daphnia similis. The obtained results revealed the FH as a very toxic compound. These results are confirmed by the EU - Directive 93/67/EEC (Commission of the European Communities) [3]. A significant reduction of the acute effects was obtained when 5kGy and 10kGy were applied.pt_BR
dc.event.siglaNUTECHpt_BR
dc.format.extent58-58pt_BR
dc.identifier.citationSANTOS, D.R.A.; GARCIA, V.S.G.; VILARRUBIA, A.C.S.; BORRELY, S.I. Acute toxicity assessment of fluoxetine hydrochloride (Prozac®) when submitted to electron beam irradiation. In: DUDALA, JOANNA (ed.); STEGOWSKI, ZDZISLAW (ed.). In: INTERNATIONAL CONFERENCE ON DEVELOPMENT AND APPLICATIONS OF NUCLEAR TECHNOLOGIES, September 11-14, 2011, Krakow, Poland. <b>Abstract...</b> Krakow, Poland: Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, 2011. p. 58-58. Disponível em: http://repositorio.ipen.br/handle/123456789/33335.
dc.identifier.orcidhttps://orcid.org/0000-0002-9692-5539
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/33335
dc.localKrakow, Polandpt_BR
dc.local.eventoKrakow, Polandpt_BR
dc.publisherFaculty of Physics and Applied Computer Science, AGH University of Science and Technologypt_BR
dc.rightsopenAccesspt_BR
dc.subjectbiological wastes
dc.subjectdrugs
dc.subjectelectron beams
dc.subjectexternal irradiation
dc.subjectliquid wastes
dc.subjectnonradioactive wastes
dc.subjecttoxicity
dc.subjectwaste processing
dc.titleAcute toxicity assessment of fluoxetine hydrochloride (Prozac®) when submitted to electron beam irradiationpt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorANNA CAROLINA FERASIN VILARRUBIA
ipen.autorSUELI IVONE BORRELY
ipen.autorVANESSA SILVA GRANADEIRO GARCIA
ipen.autorDYMES RAFAEL ALVES DOS SANTOS
ipen.codigoautor8607
ipen.codigoautor150
ipen.codigoautor6046
ipen.codigoautor8225
ipen.contributor.ipenauthorANNA CAROLINA FERASIN VILARRUBIA
ipen.contributor.ipenauthorSUELI IVONE BORRELY
ipen.contributor.ipenauthorVANESSA SILVA GRANADEIRO GARCIA
ipen.contributor.ipenauthorDYMES RAFAEL ALVES DOS SANTOS
ipen.date.recebimento22-10
ipen.event.datapadronizada2011pt_BR
ipen.identifier.ipendoc26392pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
relation.isAuthorOfPublication384a2d13-c06f-4b67-b649-09bc62b79e21
relation.isAuthorOfPublication76171e20-c8ac-475f-9006-27402113c92f
relation.isAuthorOfPublicatione3a89769-eeae-4164-9096-2a1a10a42a34
relation.isAuthorOfPublicationb808818e-3258-41e2-9a23-bc87abec3dc6
relation.isAuthorOfPublication.latestForDiscoveryb808818e-3258-41e2-9a23-bc87abec3dc6
sigepi.autor.atividadeBORRELY, S.I.:150:220:Npt_BR
sigepi.autor.atividadeVILARRUBIA, A.C.S.:8607:-1:Npt_BR
sigepi.autor.atividadeGARCIA, V.S.G.:6046:220:Npt_BR
sigepi.autor.atividadeSANTOS, D.R.A.:8225:-1:Spt_BR
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