Acute toxicity assessment of fluoxetine hydrochloride (Prozac®) when submitted to electron beam irradiation
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2011
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INTERNATIONAL CONFERENCE ON DEVELOPMENT AND APPLICATIONS OF NUCLEAR TECHNOLOGIES
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Resumo
The large-scale production of medicinal products is directly related to the presence of
pharmaceutical drugs in sewage and water. The continuous input of medicines and its residues
into the environment especially by sewage and wastewater generates an increasing need of
new methods for its treatment and suitable control. The fluoxetine hydrochloride (FH), also
known as Prozac®, is an active ingredient used in the treatment of depressive and anxiety
disorders [1]. The present study focused on applying the ionizing radiation in order to reduce
the acute toxicity of the FH drug solution, under its manipulated formula, to aquatic
organisms. Hyalella azteca and Daphnia similis were the organisms used in the biological
assays applied for the toxicity studies. It was used a Dynamitron electron beam accelerator
and its energy was fixed at 1,4MeV for 5kGy and 10kGy doses [2]. For the calculation of the
effective concentration (EC50) it was used the statistic program Trimmed Spearman - Karber.
The average values for acute toxicity of FH were 0.59mg.L-1 (EC5 096h) for Hyalella azteca
and of 1,44mg.L-1 (EC5 048h) for Daphnia similis. After irradiation of the FH aqueous
solution, the following EC50 average values were obtained: 7.81mg.L-1 (5kGy) and
7.97mg.L-1 (10kGy) for Hyalella azteca; 8,46mg.L-1 (5kGy ) and 7.31mg.L-1 (10kGy ) for
Daphnia similis. The obtained results revealed the FH as a very toxic compound. These
results are confirmed by the EU - Directive 93/67/EEC (Commission of the European
Communities) [3]. A significant reduction of the acute effects was obtained when 5kGy and
10kGy were applied.
Como referenciar
SANTOS, D.R.A.; GARCIA, V.S.G.; VILARRUBIA, A.C.S.; BORRELY, S.I. Acute toxicity assessment of fluoxetine hydrochloride (Prozac®) when submitted to electron beam irradiation. In: DUDALA, JOANNA (ed.); STEGOWSKI, ZDZISLAW (ed.). In: INTERNATIONAL CONFERENCE ON DEVELOPMENT AND APPLICATIONS OF NUCLEAR TECHNOLOGIES, September 11-14, 2011, Krakow, Poland. Abstract... Krakow, Poland: Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, 2011. p. 58-58. Disponível em: http://repositorio.ipen.br/handle/123456789/33335. Acesso em: 11 May 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.