Study of 99mTc-DMSA biodistribution in experimental animals

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dc.contributor.authorCASTRO, THAIS O.M. de
dc.contributor.authorSILVA, NATANAEL G. da
dc.contributor.authorCOLTURATO, MARIA T.
dc.contributor.authorFELGUEIRAS, CARLOS F.
dc.contributor.authorMENGATTI, JAIR
dc.contributor.authorFUKUMORI, NEUZA T.O.
dc.contributor.authorMATSUDA, MARGARETH M.N.
dc.contributor.authorARAUJO, ELAINE B. de
dc.coverageInternacionalpt_BR
dc.creator.eventoINTERNATIONAL NUCLEAR ATLANTIC CONFERENCEpt_BR
dc.date.accessioned2018-01-11T11:00:38Z
dc.date.available2018-01-11T11:00:38Z
dc.date.eventoOctober 22-27, 2017pt_BR
dc.description.abstract99mTc-DMSA, succimer (99m Tc), is a radiopharmaceutical commonly used in nuclear medicine for renal function evaluation by imaging. In order to achieve adequate labeling of the product with good radiochemical yield and standardized biological distribution, the interval of 185 - 3700 MBq should be kept in a maximum volume of 3 mL for product labeling. Moreover, one should avoid exposing the reconstituted solution to oxygen and using the product after four hours post labeling. The aim of the study was to quantify and evaluate the influence of different DMSA complexes on biological distribution of the radiopharmaceutical in experimental animals, taking in account variations in the labeling parameters. Radiochemical purity was determined by paper and thin layer chromatography using both acetone/Whatman 3MM, 0.9% NaCl/TLC-SG and npropanol/ H2O/acetic acid (4:3:1 V/V/V)/TLC-SG systems respectively for quantification of 99mTcO4 - and 99mTcO2 plus some 99mTc-DMSA complexes. The labeling activity did not significantly affect the extent of the main complex generation. The presence of oxygen and the concentration of 99Tc did not markedly change the percentage of the radiochemical impurities in the preparation. Radiochemical purity tests of the DMSA-99mTc based on IPEN-CNEN DMSA-TEC reagent and on another producer’s reagent showed similar results. Although the routine method used by IPEN-CNEN to determine the radiochemical yield of 99mTc-DMSA was not able to discriminate among 99mTc-DMSA complexes, the renal uptake and the kidney to liver plus spleen uptake ratio in rats met the official compendia criteria for the radiopharmaceutical.pt_BR
dc.event.siglaINACpt_BR
dc.identifier.citationCASTRO, THAIS O.M. de; SILVA, NATANAEL G. da; COLTURATO, MARIA T.; FELGUEIRAS, CARLOS F.; MENGATTI, JAIR; FUKUMORI, NEUZA T.O.; MATSUDA, MARGARETH M.N.; ARAUJO, ELAINE B. de. Study of 99mTc-DMSA biodistribution in experimental animals. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE, October 22-27, 2017, Belo Horizonte, MG. <b>Proceedings...</b> Rio de Janeiro, RJ: Associação Brasileira de Energia Nuclear, 2017. Disponível em: http://repositorio.ipen.br/handle/123456789/28281.
dc.identifier.orcidhttps://orcid.org/0000-0003-0456-5589
dc.identifier.orcidhttps://orcid.org/0000-0003-4455-3486
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/28281
dc.localRio de Janeiro, RJpt_BR
dc.local.eventoBelo Horizonte, MGpt_BR
dc.publisherAssociação Brasileira de Energia Nuclearpt_BR
dc.rightsopenAccesspt_BR
dc.subjectimpurities
dc.subjectlabelling
dc.subjectradionuclide kinetics
dc.subjectradiopharmaceuticals
dc.subjectrats
dc.subjectsuccinic acid
dc.subjecttechnetium 99
dc.subjectthin-layer chromatography
dc.subjectuptake
dc.titleStudy of 99mTc-DMSA biodistribution in experimental animalspt_BR
dc.typeTexto completo de eventopt_BR
dspace.entity.typePublication
ipen.autorCARLOS FARIAS FELGUEIRAS
ipen.autorJAIR MENGATTI
ipen.autorELAINE BORTOLETI DE ARAUJO
ipen.autorMARGARETH MIE NAKAMURA MATSUDA
ipen.autorNEUZA TAEKO OKASAKI FUKUMORI
ipen.autorMARIA TEREZA COLTURATO
ipen.autorNATANAEL GOMES DA SILVA
ipen.autorTHAIS OLIVEIRA MENDES DE CASTRO
ipen.codigoautor9682
ipen.codigoautor1498
ipen.codigoautor664
ipen.codigoautor841
ipen.codigoautor1514
ipen.codigoautor434
ipen.codigoautor750
ipen.codigoautor12095
ipen.contributor.ipenauthorCARLOS FARIAS FELGUEIRAS
ipen.contributor.ipenauthorJAIR MENGATTI
ipen.contributor.ipenauthorELAINE BORTOLETI DE ARAUJO
ipen.contributor.ipenauthorMARGARETH MIE NAKAMURA MATSUDA
ipen.contributor.ipenauthorNEUZA TAEKO OKASAKI FUKUMORI
ipen.contributor.ipenauthorMARIA TEREZA COLTURATO
ipen.contributor.ipenauthorNATANAEL GOMES DA SILVA
ipen.contributor.ipenauthorTHAIS OLIVEIRA MENDES DE CASTRO
ipen.date.recebimento18-01pt_BR
ipen.event.datapadronizada2017pt_BR
ipen.identifier.ipendoc24106pt_BR
ipen.notas.internasProceedingspt_BR
ipen.type.genreArtigo
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sigepi.autor.atividadeCASTRO, THAIS O.M. DE:12095:130:Spt_BR
sigepi.autor.atividadeSILVA, NATANAEL G. DA:750:110:Npt_BR
sigepi.autor.atividadeCOLTURATO, MARIA T.:434:110:Npt_BR
sigepi.autor.atividadeFELGUEIRAS, CARLOS F.:9682:120:Npt_BR
sigepi.autor.atividadeMENGATTI, JAIR:1498:110:Npt_BR
sigepi.autor.atividadeFUKUMORI, NEUZA T.O.:1514:110:Npt_BR
sigepi.autor.atividadeMATSUDA, MARGARETH M.N.:841:110:Npt_BR
sigepi.autor.atividadeARAUJO, ELAINE B. DE:664:110:Npt_BR
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