Differences in iron concentrations in whole blood of animals model using NAA
Carregando...
Data
Data de publicação:
2017
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
É parte de
60 YEARS OF IEA-R1: INTERNATIONAL WORKSHOP ON UTILIZATION OF RESEARCH REACTORS
Exportar
Resumo
In this study Neutron Activation Analysis technique (NAA) was applied to determine
Fe concentrations in whole blood samples of several animals model: mice (Mus
musculus), Golden Hamsters (Mesocricetus auratus), Wistar rats, Albinic Rabbits of
New Zealand, Golden Retriever dogs and Crioula breed horses. In the health area
these animals model are used for several investigations, mainly those that involve
testing of new medicines, vaccines, antibiotics, anesthetics, antidepressants, organs
transplantation as well as medical diagnostic studies. While small-sized animals model
(mice, hamsters, rats and rabbits ) are very convenient to perform medical investigation
due to the low cost, easy handling and medico-legal implications, medium
and large sized animals, (mainly Golden Retrievers dogs) are selected for medical
diagnostic studies because of their physiological similarities with the humans. Particularly,
in this study, horses (Crioula breed) were also investigated because they
are frequently used for antivenom production in Brazil. An important aspect to be
considered during these medical investigations is the needs to check for similarities
between the animal’s blood and the human’s blood. Besides, considering that Fe
plays important functions in blood (acts as indicator of a great number of anomalies)
consulting these data is possible to select the convenient animal model for experiments
which the similarities with the humans are an important condition. The NAA
measurements were performed in the nuclear reactor IEA-R1 (3.5-4.5MW, pool type)
at IPEN/CNEN-SP (Brazil). Fe concentrations results in the blood of these animals
were compared with human blood estimative and some significant differences were
identified.
Como referenciar
SILVA, L.F.F.L.; ZAMBONI, C.B.; BAHOVSCHI, V.; METAIRON, S.; MEDEIROS, I.M.M.A. Differences in iron concentrations in whole blood of animals model using NAA. In: 60 YEARS OF IEA-R1: INTERNATIONAL WORKSHOP ON UTILIZATION OF RESEARCH REACTORS, November 28 - December 01, 2017, São Paulo, SP. Abstract... São Paulo, SP: Instituto de Pesquisas Energéticas e Nucleares, 2017. p. 31-31. Disponível em: http://repositorio.ipen.br/handle/123456789/28727. Acesso em: 11 May 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.