Effectiveness in total reduction of Candida albicans promoted by PDT with hypocrellin B: lanthanum
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2009
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WORLD CONGRESS OF THE INTERNATIONAL PHOTODYNAMIC ASSOCIATION CONFERENCE PHOTODYNAMIC THERAPY: BACK TO THE FUTURE, 12th
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In this work we described the potentiality of the Hypocrellin B (HB) modified with the presence of lanthanum (La3+)
ions, in eliminate Candida albicans in suspension. The results showed that the presence of lanthanum ions promotes a
red shift of the HB absorption band and an enhancement in singlet oxygen quantum yield in 32%. Also in this work we
obtained that the best molar ration between HB and La concentrations was 1:2. No photobleaching was observed in our
experimental conditions. Antimicrobial activity was studied exciting C. albicans suspension with a 460 nm LED and a
660 nm laser both with 330 mW/cm2
irradiance. Best irradiation time, PS concentration and ROS production profile
were determined showing that using 460 nm LED with 10 μM of PS, only 30 s of irradiation time was sufficient to
reduce 100 % C. albicans colonies.
Como referenciar
TOFOLLI, DANIEL J.; PRATES, RENATO A.; RIBEIRO, MARTHA S.; VIEIRA JUNIOR, NILSON D.; HASHIMOTO, M.C.E.; COURROL, LILIA C. Effectiveness in total reduction of Candida albicans promoted by PDT with hypocrellin B: lanthanum. In: WORLD CONGRESS OF THE INTERNATIONAL PHOTODYNAMIC ASSOCIATION CONFERENCE PHOTODYNAMIC THERAPY: BACK TO THE FUTURE, 12th, June 11-15, 2009, Seattle, WA. Proceedings... Disponível em: http://repositorio.ipen.br/handle/123456789/16697. Acesso em: 19 Feb 2025.
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