Biochemical changes in cutaneous squamous cell carcinoma submitted to PDT using ATR-FTIR spectroscopy
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2015
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BIOPHOTONICS SOUTH AMERICA
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Nonmelanoma skin cancers are the most common form of malignancy in humans. Between the
traditional treatment ways, the photodynamic therapy (PDT) is a promising alternative which is
minimally invasive and do not requires surgical intervention or exposure to ionizing radiation. The
understanding of the cascade of effects playing role in PDT is not fully understood, so that define
and understand the biochemical events caused by photodynamic effect will hopefully result in
designing better PDT protocols. In this study we investigated the potential of the FTIR spectroscopy
to assess the biochemical changes caused by photodynamic therapy after 10 and 20 days of treatment
using 5-aminolevulinic acid (ALA) as precursor of the photosensitizer photoporphyrin IX (PpIX).
The amplitude values of second derivative from vibrational modes obtained with FTIR spectroscopy
showed similar behavior with the morphological features observed in histopathological analysis,
which showed active lesions even 20 days after PDT. Thus, the technique has the potential to be
used to complement the investigation of the main biochemical changes that photodynamic therapy
promotes in tissue.
Como referenciar
LIMA, CASSIO A.; GOULART, VIVIANE P.; CASTRO, PEDRO A.A. de; CORREA, LUCIANA; BENETTI, CAROLINA; ZEZELL, DENISE M. Biochemical changes in cutaneous squamous cell carcinoma submitted to PDT using ATR-FTIR spectroscopy. In: KURACHI, CRISTINA (ed.); SVANBERG, KATARINA (ed.); TROMBERG, BRUCE J. (ed.); BAGNATO, VANDERLEI S. (ed.). In: BIOPHOTONICS SOUTH AMERICA, May 23, 2015, Rio de Janeiro, RJ. Proceedings... p. 95311J1-1 - 95311J1-7. (SPIE Proceedings Series, 9531). DOI: 10.1117/12.2181067. Disponível em: http://repositorio.ipen.br/handle/123456789/23813. Acesso em: 19 Feb 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.