Enhancement of chlorpromazine antitumor activity by pluronics F127/L81 nanostructured system against human multidrug resistant leukemia
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2016
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Pharmacological Research
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The development of specific tyrosine kinase inhibitors (TKIs) revolutionized the treatment of chronic
myeloid leukemia (CML). However, chemoresistance of tumor cells to TKIs has already been described,
and several mechanisms account for the multidrug resistance (MDR) phenotypes, including the overexpression of P-glycoprotein (P-gp). This decreases the rate of healing and complete tumor remission.
Nanotechnological tools have been studied to allow advances in this field. Poloxamers (Pluronics®) have
been proposed as drug carriers to improve therapeutic efficacy and decrease side effects, even in cancer
therapy, due to their ability to inhibit P-gp. Antipsychotic phenothiazines have been described as potent
cytotoxic drugs against several types of tumor cells in vitro. Here, we show that nanostructured micellar systems containing the phenothiazine derivative chlorpromazine (CPZ) potentiated the cytotoxicity
of free CPZ and increased the selectivity against CML tumor cells, demonstrating the pharmacological
potential of these poloxamer-based nanostructured systems containing CPZ in cancer therapy.
Como referenciar
MELLO, JOYCE C. de; MORAES, VIVIAN W.R.; WATASHI, CAROLINA M.; SILVA, DEYSE C. da; CAVALCANTI, LEIDE P.; FRANCO, MARGARETH K.K.D.; YOKAICHIYA, FABIANO; ARAUJO, DANIELE R. de; RODRIGUES, TIAGO. Enhancement of chlorpromazine antitumor activity by pluronics F127/L81 nanostructured system against human multidrug resistant leukemia. Pharmacological Research, v. 111, p. 102-112, 2016. DOI: 10.1016/j.phrs.2016.05.032. Disponível em: http://repositorio.ipen.br/handle/123456789/26585. Acesso em: 16 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.