Chlorhexidine loaded MMT as dental composite filler: release evaluation
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2016
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BRAZILIAN CONFERENCE ON COMPOSITE MATERIALS, 3rd
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Resumo
Polymeric restorative materials are widely used, however polymerization shrinkage still
stands as a major drawback as it allows microleakage, secondary caries, postoperative sensitivity and
cusp deflection. A polymeric material with antimicrobial activity could be very useful in many dental
procedures including adhesive cementation, sealants, dental adhesives and direct restorative material.
The aim of this study was to develop nanocomposites for dental purposes composed by chlorhexidine
loaded montmorillonite (Cloisite 30B) nanoparticles in a BisGMA / TEGDMA organic matrix. The
specimens of experimental composites were synthesized with 10 % (w/w) of diacetate chlorhexidine
incorporated in a MMT, as filler. The chlorhexidine release at 37 oC was evaluated in vitro in
physiological solution at neutral pH for 366 hours. Drug content was estimated by UV spectroscopy at
λ=255 nm. Significant drug release initiated after 96 hours and maintained throughout the experiment.
In conclusion, the composite was capable of promoting chlorhexidine release over time, and such
results in addition to the lack of significant weight loss (≤ 1.43 %) and the very low swelling (≤ 2.22
%) properties, revealed the strong potential of the developed composite for further dental and other
biomaterial applications.
Como referenciar
CAMPOS, LUIZA M.; BOARO, LETICIA C.; SANTOS, TAMIRIS R.; SANTOS, VINICIUS J.; VARCA, GUSTAVO C.; PARRA, DUCLERC F. Chlorhexidine loaded MMT as dental composite filler: release evaluation. In: BRAZILIAN CONFERENCE ON COMPOSITE MATERIALS, 3rd, August 28-31, 2016, Gramado, RS. Proceedings... Disponível em: http://repositorio.ipen.br/handle/123456789/26738. Acesso em: 13 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.