Multimodal evaluation of ultra-short laser pulses treatment for skin burn injuries
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2017
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Biomedical Optics Express
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Thousands of people die every year from burn injuries. The aim of this study is to
evaluate the feasibility of high intensity femtosecond lasers as an auxiliary treatment of skin burns.
We used an in vivo animal model and monitored the healing process using 4 different imaging
modalities: histology, Optical Coherence Tomography (OCT), Second Harmonic Generation
(SHG), and Fourier Transform Infrared (FTIR) spectroscopy. 3 dorsal areas of 20 anesthetized
Wistar rats were burned by water vapor exposure and subsequently treated either by classical
surgical debridement, by laser ablation, or left without treatment. Skin burn tissues were noninvasively
characterized by OCT images and biopsied for further histopathology analysis, SHG
imaging and FTIR spectroscopy at 3, 5, 7 and 14 days after burn. The laser protocol was found as
efficient as the classical treatment for promoting the healing process. The study concludes to the
validation of femtosecond ultra-short pulses laser treatment for skinburns, with the advantage of
minimizing operatory trauma.
Como referenciar
SANTOS, MOISES O. dos; LATRIVE, ANNE; CASTRO, PEDRO A.A. de; ROSSI, WAGNER de; ZORN, TELMA M.T.; SAMAD, RICARDO E.; FREITAS, ANDERSON Z.; CESAR, CARLOS L.; VIEIRA JUNIOR, NILSON D.; ZEZELL, DENISE M. Multimodal evaluation of ultra-short laser pulses treatment for skin burn injuries. Biomedical Optics Express, v. 8, n. 3, p. 1575-1588, 2017. DOI: 10.1364/BOE.8.001575. Disponível em: http://repositorio.ipen.br/handle/123456789/27028. Acesso em: 26 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.